Reaction‐Induced Self‐Assembly of Polymyxin Mitigates Cytotoxicity and Reverses Drug Resistance
Xiaowen Hu,
Dongdong Li,
Huaping Li
et al.
Abstract:Polymyxins have been regarded as an efficient therapeutic against many life‐threatening, multidrug resistant Gram‐negative bacterial infections; however, the cytotoxicity and emergence of drug resistance associated with polymyxins have greatly hindered their clinical potential. Herein, the reaction‐induced self‐assembly (RISA) of polymyxins and natural aldehydes in aqueous solution is presented. The resulting assemblies effectively mask the positively charged nature of polymyxins, reducing their cytotoxicity. … Show more
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