Reaction-diffusion hydrogels from urease enzyme particles for patterned coatings

Anthony, Q.; Bánsági, Tamás; Taylor, Annette F.

doi:10.1038/s42004-021-00538-7

Cited by 24 publications

(19 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 5 At the same time, the capability to program self-organization provides paradigms to create novel types of matter that spontaneously generate functional patterns and structures. 6 − 9 Pattern generation from initially homogeneous solutions has been established in reaction–diffusion systems such as the Belousov–Zhabotinsky reaction 10 , 11 and the thio–urea reaction, 12 as well as via Rayleigh-Bénard convection that employs minute substrate–product buoyancy differences in an enzymatic reaction network. 13 Self-organization of complex microstructures has been demonstrated in inorganic precipitation reactions, directed by gradients that emerge around the growing structures.…”

Section: Introductionmentioning

confidence: 99%

Self-Organization Emerging from Marangoni and Elastocapillary Effects Directed by Amphiphile Filament Connections

Winkens¹,

Korevaar²

2022

Langmuir

View full text Add to dashboard Cite

Self-organization of meso- and macroscale structures is a highly active research field that exploits a wide variety of physicochemical phenomena, including surface tension, Marangoni flow, and (elasto)capillary effects. The release of surface-active compounds generates Marangoni flows that cause repulsion, whereas capillary forces attract floating particles via the Cheerios effect. Typically, the interactions resulting from these effects are nonselective because the gradients involved are uniform. In this work, we unravel the mechanisms involved in the self-organization of amphiphile filaments that connect and attract droplets floating at the air–water interface, and we demonstrate their potential for directional gradient formation and thereby selective interaction. We simulate Marangoni flow patterns resulting from the release and depletion of amphiphile molecules by source and drain droplets, respectively, and we predict that these flow patterns direct the growth of filaments from the source droplets toward specific drain droplets, based on their amphiphile depletion rate. The interaction between such droplets is then investigated experimentally by charting the flow patterns in their surroundings, while the role of filaments in source–drain attraction is studied using microscopy. Based on these observations, we attribute attraction of drain droplets and even solid objects toward the source to elastocapillary effects. Finally, the insights from our simulations and experiments are combined to construct a droplet-based system in which the composition of drain droplets regulates their ability to attract filaments and as a consequence be attracted toward the source. Thereby, we provide a novel method through which directional attraction can be established in synthetic self-organizing systems and advance our understanding of how complexity arises from simple building blocks.

show abstract

Section: Introductionmentioning

confidence: 99%

Self-Organization Emerging from Marangoni and Elastocapillary Effects Directed by Amphiphile Filament Connections

Winkens¹,

Korevaar²

2022

Langmuir

View full text Add to dashboard Cite

show abstract

“…Enzymatic reactions can balance competing reactions and improve internal self-healing ability. Monoamine oxidase B (MAO B), catalase (CAT), plasma amine oxidase (PAO), and urease have been reported to regulate the self-healing properties of dynamic covalent hydrogels [ 92 , 93 , 94 , 95 ]. In particular, another advantage of hydrogels for enzymatic reactions is that hydrogels provide a protective environment for the enzyme, which avoids enzyme denaturation and inactivation in inferior conditions [ 96 , 97 ].…”

Section: Dynamic Covalent Chemistrymentioning

confidence: 99%

Dynamic Covalent Hydrogels: Strong yet Dynamic

Han

Cao

Lei

2022

Gels

View full text Add to dashboard Cite

Hydrogels are crosslinked polymer networks with time-dependent mechanical response. The overall mechanical properties are correlated with the dynamics of the crosslinks. Generally, hydrogels crosslinked by permanent chemical crosslinks are strong but static, while hydrogels crosslinked by physical interactions are weak but dynamic. It is highly desirable to create synthetic hydrogels that possess strong mechanical stability yet remain dynamic for various applications, such as drug delivery cargos, tissue engineering scaffolds, and shape-memory materials. Recently, with the introduction of dynamic covalent chemistry, the seemingly conflicting mechanical properties, i.e., stability and dynamics, have been successfully combined in the same hydrogels. Dynamic covalent bonds are mechanically stable yet still capable of exchanging, dissociating, or switching in response to external stimuli, empowering the hydrogels with self-healing properties, injectability and suitability for postprocessing and additive manufacturing. Here in this review, we first summarize the common dynamic covalent bonds used in hydrogel networks based on various chemical reaction mechanisms and the mechanical strength of these bonds at the single molecule level. Next, we discuss how dynamic covalent chemistry makes hydrogel materials more dynamic from the materials perspective. Furthermore, we highlight the challenges and future perspectives of dynamic covalent hydrogels.

show abstract

“…Clock and oscillating reactions have been coupled to pre-made gels to obtain chemomechanical oscillations, such as in the seminal 1996 paper of Yoshida and collaborators on the BZ-powered self-oscillating gel [48], or as described in the excellent 2014 work of Horváth where synergetic chemomechanical oscillations were obtained by coupling pH-responsive gels with the Landolt iodine clock in a CSTR reactor [49]. The usefulness of pH clocks and kinetic switches to control gelation in time has been demonstrated using slow acid generators, such as δ-gluconolactone [50], or, most often, using enzymatic systems such as urease-urea [51,52].…”

Section: Gel Systemsmentioning

confidence: 99%

Iodine clocks: applications and untapped opportunities in materials science

Panzarasa

2022

Reac Kinet Mech Cat

View full text Add to dashboard Cite

Iodine clocks are fascinating nonlinear chemical systems with a glorious past and a promising future. The dynamic removal of iodine from these systems by different means can have important consequences for their reaction dynamics, and could be exploited for time-controlled autonomous dissipative self-assembly. Here, the untapped opportunities offered by iodine clocks for materials science, especially for the time-programming of supramolecular assembly and sol–gel transition, are reviewed and discussed with the hope of arousing the interest on the subject and stimulating new research directions.

show abstract

Reaction-diffusion hydrogels from urease enzyme particles for patterned coatings

Cited by 24 publications

References 59 publications

Self-Organization Emerging from Marangoni and Elastocapillary Effects Directed by Amphiphile Filament Connections

Self-Organization Emerging from Marangoni and Elastocapillary Effects Directed by Amphiphile Filament Connections

Dynamic Covalent Hydrogels: Strong yet Dynamic

Iodine clocks: applications and untapped opportunities in materials science

Contact Info

Product

Resources

About