Reaching task performance is associated to neuromuscular junction adaptations in rats with induced diabetes mellitus

Estrada‐Bonilla, Yisel Carolina; Castro, Paula Aiello Tomé de Souza; Luna, Genoveva Lourdes Flores; Souza, Alan; Santos, Gledinélio Silva; Salvini, Tania F.; Leal, Ângela M. O.; Russo, Thiago Luiz

doi:10.1590/1414-431x20208763

Cited by 6 publications

(7 citation statements)

References 37 publications

(53 reference statements)

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“…Severe deficits in motor neurons are not seen until late in diabetic pathology where severe force deficits and motor neuron loss is observed [ 142 ]. However, there are minute, observable changes such as axonal sprouting, demyelination, and a decrease in both NMJ and motor unit number that occur in the beginning stages of diabetes [ 142 , 143 ]. AGEs destroy the microvasculature around motor nerves, slowing the conduction velocity [ 138 , 144 , 145 , 146 ].…”

Section: Peripheral Nerve Involvement In Aging and Atrophymentioning

confidence: 99%

Advanced Glycation End-Products in Skeletal Muscle Aging

et al. 2021

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Advanced age causes skeletal muscle to undergo deleterious changes including muscle atrophy, fast-to-slow muscle fiber transition, and an increase in collagenous material that culminates in the age-dependent muscle wasting disease known as sarcopenia. Advanced glycation end-products (AGEs) non-enzymatically accumulate on the muscular collagens in old age via the Maillard reaction, potentiating the accumulation of intramuscular collagen and stiffening the microenvironment through collagen cross-linking. This review contextualizes known aspects of skeletal muscle extracellular matrix (ECM) aging, especially the role of collagens and AGE cross-linking, and underpins the motor nerve’s role in this aging process. Specific directions for future research are also discussed, with the understudied role of AGEs in skeletal muscle aging highlighted. Despite more than a half century of research, the role that intramuscular collagen aggregation and cross-linking plays in sarcopenia is well accepted yet not well integrated with current knowledge of AGE’s effects on muscle physiology. Furthermore, the possible impact that motor nerve aging has on intramuscular cross-linking and muscular AGE levels is posited.

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Section: Peripheral Nerve Involvement In Aging and Atrophymentioning

confidence: 99%

Advanced Glycation End-Products in Skeletal Muscle Aging

et al. 2021

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Section: Discussionmentioning

confidence: 99%

“…In Boehm et al 48 work, each animal species has a different endplate diameter value. Indeed, Estrada-Bonilla et al 49 observed the NMJ morphometric characteristics of the upper limbs of healthy and diabetes mellitus-induced rats. These data differ from the lower limbs found in this study.…”

Section: Articlementioning

confidence: 99%

“…There were also minor values in the diameter in conditions of diabetes compared to the control. 49 However, the climbing training with and without an additional load in alternate sessions increases the endplate diameter and even the number of the biceps brachii muscle postsynaptic cleft. 26 Regarding the fragmentation index, Prakash and Sieck 50 found the effects of aging on NMJs morphological adaptations such as altered fragmentation.…”

Section: Articlementioning

confidence: 99%

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Stretching prior to resistance training promotes adaptations on the postsynaptic region in different myofiber types

et al. 2022

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The morphology of the neuromuscular junction adapts according to changes in its pattern of use, especially at the postsynaptic region according to the myofibrillar type and physical exercise. This investigation revealed the morphological adaptations of the postsynaptic region after static stretching, resistance training, and their association in adult male Wistar rats. We processed the soleus and plantaris muscles for histochemical (muscle fibers) and postsynaptic region imaging techniques. We observed muscle hypertrophy in both groups submitted to resistance training, even though the cross-section area is larger when there is no previous static stretching. The soleus postsynaptic region revealed higher compactness and fragmentation index in the combined exercise. The resistance training promoted higher adaptations in the postsynaptic area of plantaris; moreover, the previous static stretching decreased this area. In conclusion, the neuromuscular system’s components responded according to the myofiber type even though it is the same physical exercise. Besides, static stretching (isolated or combined) plays a crucial role in neuromuscular adaptations.

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“…In Boehm et al 36 work, each animal species has a different value of endplate diameter. Indeed, Estrada-Bonilla et al 37 observed the NMJ morphometric characteristics of the upper limbs of healthy and diabetes mellitusinduced rats. These data differ from the lower limbs found in this study.…”

Section: Discussionmentioning

confidence: 99%

The previous stretching to resistance training promotes adaptations on the postsynaptic region in different myofiber types

Jacob

Barbosa

Rodrigues

et al. 2021

Preprint

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This investigation revealed the postsynaptic morphological adaptations in static stretching, resistance training, and their association in adult male Wistar rats. We processed the soleus and plantaris muscle for histochemical (muscle hypertrophy) and postsynaptic region imaging techniques. We observed muscle hypertrophy in both groups submitted to resistance training, even though the cross-section area is larger when there is no previous static stretching. The soleus postsynaptic region revealed an increase in compactness and fragmentation index in combined exercise. The resistance training promotes high adaptations in the postsynaptic area of plantaris; moreover, the previous static stretching decreased this area. In conclusion, the neuromuscular system’s components respond according to the myofiber type even though it is the same physical exercise. Besides, static stretching (isolated or combined) plays a crucial role in neuromuscular adaptations.

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Reaching task performance is associated to neuromuscular junction adaptations in rats with induced diabetes mellitus

Cited by 6 publications

References 37 publications

Advanced Glycation End-Products in Skeletal Muscle Aging

Advanced Glycation End-Products in Skeletal Muscle Aging

Stretching prior to resistance training promotes adaptations on the postsynaptic region in different myofiber types

The previous stretching to resistance training promotes adaptations on the postsynaptic region in different myofiber types

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