Re: Urogenital involvement in the Klippel-Trenaunay-Weber Syndrome. Treatment options and results

Vicentini, Fábio Carvalho

doi:10.1590/s1677-55382007000200019

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Partial cystectomy used to be the standard therapy but carries significant morbidity [3,4]. Less invasive treatment options with their specific limitations and complications have been proposed, such as laser photocoagulation, which is a feasible option for smaller lesions, with some good reported results [5,[10][11][12]. Transurethral resection and endoscopic biopsy have been strongly discouraged because of the risk of excessive bleeding [9,10,13,14].…”

Section: Discussionmentioning

confidence: 99%

“…A conservative approach of bladder irrigation and close follow-up was chosen as therapy, which is the recommended initial treatment for moderate and infrequent episodes of hematuria. Antifibrinolytic agents such as epsilon amino-caproic or tranexamic acid can also be used [ 5 , 8 , 9 ]. When conservative management is insufficient, a more invasive approach is considered especially for frequent or life-threatening hematuria.…”

Section: Discussionmentioning

confidence: 99%

“…Its most frequent clinical manifestation is hematuria, and the diagnosis is usually based on the characteristic cystoscopic appearance of the tumor. Different treatments have been proposed; partial cystectomy used to be the standard therapy [ 3 , 4 ], and laser photocoagulation is also a feasible option for smaller lesions [ 5 ]. We report the case of a 26-year-old female who was admitted with recurrent macroscopic hematuria due to bladder hemangioma associated with KTS.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Klippel-Trenaunay Syndrome Associated With Urinary Tract Hemangiomas: A Case Report

Ramdani,

El Moudane,

Tahri

et al. 2023

Cureus

View full text Add to dashboard Cite

The association between Klippel-Trenauney syndrome (KTS) and bladder hemangiomas is rare. The most common clinical manifestation is hematuria. The diagnosis is made from the characteristic cystoscopic appearance of the tumor. We report the case of a patient presenting recurrent macroscopic hematuria in the context of KTS. A cystoscopic evaluation revealed bladder hemangiomas. A conservative approach consisting of bladder irrigation and close follow-up was chosen as therapy. Conservative treatment of bladder irrigation and close follow-up is the recommended initial treatment of moderate and infrequent episodes of hematuria in this context. The more invasive therapeutic options have to be considered especially for frequent or life-threatening episodes of hematuria. This case suggests that conservative treatment may be effective in treating moderate and infrequent episodes of hematuria due to bladder hemangioma in the context of KTS. Further studies are required to adequately establish the effectiveness, limitations, and complications of each approach.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Klippel-Trenaunay Syndrome Associated With Urinary Tract Hemangiomas: A Case Report

Ramdani,

El Moudane,

Tahri

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

Literature Watch

Blei¹

2007

Lymphatic Research and Biology

View full text Add to dashboard Cite

135 FEATURED ARTICLE Kobayashi, S., T. Kishimoto, et al. (2007). Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis. Cancer Sci 98(5): 726-33. AbstractTumor lymphangiogenesis is now known to play a causal role in lymph node metastasis, and thus its inhibition would have great significance for the prevention of lymph node metastasis in cancer therapy. VEGF-C has recently been identified as a key molecule involved in tumor lymphangiogenesis and lymphatic metastasis. However, the expressional regulation of VEGF-C is not fully understood. We investigated the role of mTOR, which is a downstream kinase of the phosphatidylinositol 3-kinase/Akt pathway, and the MAPK family (MEK1/2, p38, and JNK) in the regulation of VEGF-C and VEGF-A expression in B13LM cells, a lymphatic metastasis-prone pancreatic tumor cell line. We also investigated the antilymphangiogenic effect of rapamycin, a specific inhibitor of mTOR in vivo using male BALB/c nu/nu mice. VEGF-C expression was inhibited by the inhibitors for mTOR, p38, and JNK, but not by the inhibitor for MEK1/2, whereas VEGF-A expression was inhibited by all four of these inhibitors. The serum starvation-induced expression of VEGF-C was inhibited by rapamycin, whereas that of VEGF-A was incompletely inhibited. The metastatic experiment in vivo demonstrated that the number and the area of lymphatic vessels in the primary tumors were significantly decreased by rapamycin. Finally, the lymph node metastasis was significantly suppressed in rapamycin- LITERATURE WATCH136 LITERATURE WATCH 137

show abstract

Re: Urogenital involvement in the Klippel-Trenaunay-Weber Syndrome. Treatment options and results

Cited by 2 publications

References 0 publications

Klippel-Trenaunay Syndrome Associated With Urinary Tract Hemangiomas: A Case Report

Klippel-Trenaunay Syndrome Associated With Urinary Tract Hemangiomas: A Case Report

Literature Watch

Contact Info

Product

Resources

About