Re: The impact of machine perfusion of the heart on warm ischemia time and organ yield in donation after circulatory death

Okumura, Kenji; Misawa, Ryosuke; Ohira, Suguru; Dhand, Abhay; Kai, Masashi; Nishida, Seigo

doi:10.1111/ajt.17040

Cited by 2 publications

(2 citation statements)

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“…29 Of note, additional donor WIT contributed by blood collection utilizing HM might not be accurately reflected as time from a skin incision to cold abdominal organ flush is not available in this database. 30 When using a timeline from pronouncement of death to abdominal organ flush, overall delay in operative WIT was noted for both LT and KT in the HM group.…”

Section: Abdominal Organ Transplantation and Donor Witmentioning

confidence: 93%

“…31 Compared to Feizpour et al, 29 our study had a few methodological differences: we investigated donor WIT in recipients who underwent only LT or KT, we defined WIT differently based on the definition of controlled DCD, 23 and we excluded DCD heart recovery with HM for research, where the heart team might not delay the flushing of abdominal organs. 30…”

Section: Abdominal Organ Transplantation and Donor Witmentioning

confidence: 99%

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Does utilization of heart machine perfusion for donation after cardiac death transplantation affect outcomes of other abdominal transplanted organs?

Okumura

Misawa

Ohira

et al. 2022

Clinical Transplantation

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Introduction: Machine perfusion of heart for donation after circulatory death (DCD) is being increasingly utilized. Current protocols for utilizing heart DCD's machine perfusion might prolong donor warm ischemic time for nonheart organs. The aim of this study was to analyze the effects of utilizing heart machine perfusion on liver and kidney transplants from the same donor. Methods:We analyzed data of DCD donors from the United Network for Organ Sharing (UNOS) from January-2020 to September-2021 among two groups: donors with heart machine perfusion (HM) and without heart machine perfusion (NHM). Propensity score (PS) matching was performed to compare the short-term outcomes of liver and kidney transplants between two groups.Results: Total of 102 liver and 319 kidney transplants were performed using organs from donors with HM. After PS matching, no statistically significant difference was seen in 1-year graft survival (GS) for both liver and kidney transplants between two groups (liver HM 90.6% vs. NHM 90.2%, p = .47; kidney HM 95.2% vs. NHM 92.9%, p = .40). There was no difference in the delayed graft function (DGF) rates in kidney transplantation (KT) (HM 42% vs. NHM 35%, p = .062). Conclusion:Utilization of heart machine perfusion in DCD donors had no significant impact on 1-year outcomes of liver and kidney transplantation. K E Y W O R D Sdonation after cardiac death, heart machine perfusion, kidney transplant, liver transplant INTRODUCTIONAs the number of solid organ transplants continues to increase, so does the number of patients on the waiting list, leading to significant shortages of organs available from donation after brain death (DBD)

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Section: Abdominal Organ Transplantation and Donor Witmentioning

confidence: 93%