Re-stenosis After Drug-eluting Stents in Cardiac Allograft Vasculopathy

Aqel, Raed; Wells, Bryan J.; Hage, Fadi G.; Tallaj, José; Benza, Raymond L.; Pamboukian, Salpy V.; Rayburn, Barry K.; McGiffin, David C.; Kirklin, James K.; Bourge, Robert C.

doi:10.1016/j.healun.2008.02.010

Cited by 17 publications

(7 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings are hypothesis generating and suggest that treatment with DES may not necessarily provide an advantage in this population of patients when compared with BMS. A limited number of studies have been performed to directly compare DES with BMS in this unique population, and results have been mixed, although most demonstrated a trend toward a reduction in ISR, although not statistically significant possibly due to small sample size . Most studies in the literature also have not demonstrated a clear reduction in TLR or clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

Drug‐Eluting Stents May Not Reduce Target Lesion Revascularization in Cardiac Allograft Vasculopathy

Park

Huo

Muller

et al. 2014

J Interven Cardiology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Drug‐Eluting Stents May Not Reduce Target Lesion Revascularization in Cardiac Allograft Vasculopathy

Park

Huo

Muller

et al. 2014

J Interven Cardiology

View full text Add to dashboard Cite

show abstract

“…CAV is currently not entirely preventable or treatable. Mechanical interventions such as drug-eluting stents 20 have shown at least temporary benefit; however, due to the diffuse nature of the epicardial and intramyocardial arterial lesions observed, stents are a suboptimal treatment. Drug therapy, such as everolimus, should be more effective than mechanical interventions.…”

Section: Discussionmentioning

confidence: 99%

Diverse morphologic manifestations of cardiac allograft vasculopathy: A pathologic study of 64 allograft hearts

Lü

Palatnik

Fishbein

et al. 2011

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

“…The risk of restenosis is perceived to be usually higher in patients after heart transplantation than in the native heart [13]. Aquel et al, Tanaka et al, and Lekston et al demonstrated that DES implantation results in lower risk of restenosis as compared to BMS [14][15][16]. We were not able to confirm that finding, probably due to the relatively small number of patients with only 2 incidents of restenosis.…”

Section: Discussionmentioning

confidence: 55%

Coronary artery disease in patients after orthotopic heart transplantation treated with percutaneous coronary intervention – a single centre experience

Sobieszczańska−Małek¹,

Zieliński²,

Karcz³

et al. 2010

pwki

View full text Add to dashboard Cite

A b s t r a c tBackground: Some patients after orthotopic heart transplantation (OHT) develop coronary focal lesions and may need interventional therapy.Aim: To determine the frequency and time course of narrowing of epicardial coronary arteries in transplanted hearts, potential risk factors and results of percutaneous coronary interventions.Methods and results: Demographic and coronary angiography data of 265 patients after OHT, mean age 53.0 ±14.6, were analysed. Significant focal narrowing of the coronary artery was diagnosed when there was a decrease of 50% or more of the lumen of the coronary artery. Mean time from OHT to the end of observation was 6.2 ±4.5 (range 0.5-23) years. Thirty-six (14%) patients after OHT had significant focal changes in coronary arteries. In 16 patients the degree of stenosis, lesion, location or calibre of the vessel was not suitable for interventional therapy. Twenty (55%; 18 men) patients underwent coronary intervention. Mean age of patients during coronary intervention was 53.5 ±9.8 years and of those without intervention at the end of observation was 52.5 ±14.9 years (NS). In patients with intervention mean time from OHT to intervention was 7.0 ±4.6 years. In patients with coronary intervention mean time from OHT to the end of observation was 10.8 ±6.5 years and in patients without intervention 5.8 ±4.1 (p < 0.001). Analysis of Kaplan-Meier curves showed that probability of coronary stenosis-free survival diminishes rapidly after 5 years following OHT. Patients who required coronary intervention had significantly higher hsCRP as compared to those without intervention (0.720 vs. 0.044, p = 0.025). There were no statistical differences between the two groups in cholesterol level, BMI or incidence of diabetes, number of acute cellular episodes or Quilty effect.Conclusions: Significant focal coronary stenoses are found mainly more than 5 years post heart transplantation. Most patients can be treated safely and effectively with percutaneous coronary intervention with contrast-induced nephropathy prophylaxis. Risk factors of coronary vasculopathy post OHT require further investigations.Key words: vasculopathy, heart transplantation, coronary artery disease, percutaneous coronary intervention S t r e s z c z e n i e Wstęp: U pacjentów po transplantacji serca (OHT) mogą się rozwijać zmiany w naczyniach wieńcowych, które niejednokrotnie wymagają leczenia interwencyjnego.Cel: Ocena przebiegu zmian w naczyniach wieńcowych, potencjalnych czynników ryzyka oraz wyników leczenia przezskórną angioplastyką wieńcową.Metody i wyniki: Analizie poddano badania koronarograficzne 265 pacjentów w wieku średnio 53,0 ±14,6 roku. Za istotne zmiany w naczyniach wieńcowych przyjęto zwężenie światła naczynia powyżej 50%. Interwencję (angioplastykę) wykonywano przy zwę-żeniu powyżej 70%. W przypadkach pośrednich wykonywano ultrasonograficzną ocenę światła naczyń wieńcowych. Średni czas od

show abstract

Re-stenosis After Drug-eluting Stents in Cardiac Allograft Vasculopathy

Cited by 17 publications

References 29 publications

Drug‐Eluting Stents May Not Reduce Target Lesion Revascularization in Cardiac Allograft Vasculopathy

Drug‐Eluting Stents May Not Reduce Target Lesion Revascularization in Cardiac Allograft Vasculopathy

Diverse morphologic manifestations of cardiac allograft vasculopathy: A pathologic study of 64 allograft hearts

Coronary artery disease in patients after orthotopic heart transplantation treated with percutaneous coronary intervention – a single centre experience

Contact Info

Product

Resources

About