Re: “Smoking and Cancer of the Uterine Cervix: Hypothesis”

Wigle, Donald T.; Mao, Yang; Grace, M.

doi:10.1093/oxfordjournals.aje.a112862

Cited by 38 publications

(16 citation statements)

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“…Tobacco use was not associated with cervical cancer in the present study: recent data (5) suggests that only squamous cell carcinoma might be associated with tobacco smoking, although even this association is still a matter of debate (30,35,36,37). The present case series was insufficient for evaluation of "cigarette smoking" as a risk factor for squamous cell carcinoma.…”

Section: E N D O M E T R I a L Cancercontrasting

confidence: 67%

Risk factors of female cancers in ragusa population (sicily) - I. Endometrium and cervix uteri cancers

Cusimano

Dardanoni

et al. 1989

Eur J Epidemiol

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A case-control study on breast, cervix and endometrium cancer cases registered in Ragusa between January 1, 1983 and June 30, 1985 has been conducted. Information on risk factors has been obtained by means of a structured questionnaire. Risk factors for endometrium cancer were: few children (1-2 vs greater than 4 OR 15.18, 95%CL 1.96-117.64), oestrogenic treatment (OR 2.20, 95%CL 1.05-4.90), obesity (Quetelet index greater than 30 vs less than 22 OR 10.42, 95%CL 1.30-83.86), family history (OR 2.87, 95% CL 1.05-7.83). Risk factors for cervix uteri cancer were: multiple abortions (greater than 2 vs 0 OR 9.87, 95%CL 1.46-66.66), no contraception (OR 8.33, 95%CL 2.38-25.00), younger age of mother at birth (OR 6.89, 95%CL 1.71-27.70). Age at menarche, age at menopause and years of fertile life were not found to be related to either endometrium or cervix uteri cancer. The existence of influencing differences (ancestry, environment, lifestyle) has been postulated.

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Section: E N D O M E T R I a L Cancercontrasting

confidence: 67%

Risk factors of female cancers in ragusa population (sicily) - I. Endometrium and cervix uteri cancers

Cusimano

Dardanoni

et al. 1989

Eur J Epidemiol

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“…Our study demonstrates that similarities exist between cervical squamous and adenocarcinomas with respect to social class, known smoking habit, oestrogen/contraceptive use and time trends, while differences exist with respect to (Wright et al, 1978;Wigle, 1980;Williams & Horm, 1977;Stellman, 1980;La Vecchia et al, 1986 (Bergsjo, 1963;Korhonen, 1980;Menczer et al, 1978;Milsom & Friberg, 1983;Tasker & Collins, 1974). Our finding, that hypertension but not diabetes was associated with adenocarcinoma rather than squamous carcinoma, is also consistent with that of Korhonen (1980).…”

Section: Discussionmentioning

confidence: 59%

Squamous and adenocarcinoma of the uterine cervix: a comparison using routine data

Silcocks¹,

Thornton‐Jones²,

Murphy³

1987

Br J Cancer

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Summary We studied the clinical, demographic and survival characteristics of more than 5,000 women registered with either squamous or adenocarcinoma of the uterine cervix in South Thames Cancer Registry over the period 1968-81. There were similarities with respect to social class, smoking habit, oestrogen/oral contraceptive use and time trends in incidence but differences between the two cancers were found with respect to age distribution, parity, method of detection and survival. Some of the data are of limited value, having been obtained only from case notes, so the results need some caution in their interpretation. However the results are broadly consistent with those of studies performed in other countries on smaller samples. A methodological issue is also raised, viz. the appropriateness of a disease with well-known characteristics as a comparison group. From our results the likely size of various associations can be judged and used in the design of future studies to clarify the epidemiology of cervical adenocarcinoma.

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“…Papillomaviruses induce proliferative lesions which, for some viral types, undergo malignant progression after long latency periods. Such progression is believed to be enhanced by specific environmental cofactors (28)(29)(30)(31)(32) …”

Section: Resultsmentioning

confidence: 99%

Specific chromosomal abnormalities characterize fibrosarcomas of bovine papillomavirus type 1 transgenic mice.

Lindgren

Sippola-Thiele

Skowroński

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

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In the BPV1.69 line of transgenic mice, the bovine papillomavirus type 1 genome elicits both benign dermal fibroblastic proliferation (fibromatoses) and malignant fibrosarcomas. Because these lesions arise only with time, nonviral factors appear to be involved. We have karyotyped several primary tumors as well as a series of low-passage cell lines derived both from fibromatoses and from fibrosarcomas. The fibrosarcomas, but not the preneoplastic fibromatoses, show consistent abnormalities of one or both of two chromosomes, chromosome 8 (trisomy or duplication) and chromosome 14 (monosomy or translocation). The chromosomal abnormalities are not a direct consequence of the viral integration, which we have mapped to chromosome 15 by in situ hybridization. These results suggest that transgenic mice can be used to study the role(s) of cytogenetic changes in tumorigenesis and may direct the search for genes involved in tumor progression.Papillomaviruses are thought to play important roles in the etiology of a variety of human malignancies, most notably in cervical cancers (1, 2). Studies of bovine papillomavirus type 1 (BPV-1) have provided much knowledge of the molecular biology of this group of DNA viruses (3). In its natural host BPV-1 induces benign fibropapillomas of the skin. In the laboratory BPV-1 transforms cultured mouse cells (4), and the products of two early viral genes, E5 and E6, have transforming properties (5,6). One recent approach to the systematic study of the multistep genesis of cancer has been to introduce oncogenes into the mouse genome with the purpose of reducing the number of steps required for tumor induction. Tumorigenesis in transgenic mice models the natural process in that different oncogenes heritably elicit specific types of tumors, and the tumors occur with a pattern that implies oncogenes are necessary but not sufficient for tumor formation (7).To dissect the relative participation of papillomaviruses and cellular factors in oncogenesis, Lacey et al. (8) produced a line of transgenic mice (BPV1.69 mice) using a plasmid containing a partial tandem duplication (1.69 copies) of the BPV-1 genome. At 8 or 9 mo of age, mice in this lineage develop two types of skin lesions, fibromatoses and fibrosarcomas (8, 9). The fibromatoses are characterized by dramatic, but benign, thickening of the dermis with concomitant atrophy of the epidermis and loss of hair. The fibrosarcomas are protuberant dermal tumors that invade locally but have not been seen to metastasize. Both the fibromatoses and the tumors contain extrachromosomal BPV-1 DNA and express viral RNA (10). In contrast, unaffected skin of the transgenic mice contains only integrated viral DNA that is not expressed (10). The state of the viral DNA and its expression thus distinguish normal skin from the fibromatoses and the fibrosarcomas but do not differentiate the two pathologic entities. These observations imply that alterations in cellular genes and/or their expression are involved in the development of malignant fibrosarcomas...

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Re: “Smoking and Cancer of the Uterine Cervix: Hypothesis”

Cited by 38 publications

References 0 publications

Risk factors of female cancers in ragusa population (sicily) - I. Endometrium and cervix uteri cancers

Risk factors of female cancers in ragusa population (sicily) - I. Endometrium and cervix uteri cancers

Squamous and adenocarcinoma of the uterine cervix: a comparison using routine data

Specific chromosomal abnormalities characterize fibrosarcomas of bovine papillomavirus type 1 transgenic mice.

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