Re: “Sex Difference in the Effects of Sociocultural Status on Diabetes and Cardiovascular Risk Factors in Mexican Americans”

Zunzunegui, V.; Selby, Joe V.

doi:10.1093/oxfordjournals.aje.a114114

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of bone marrow components in the treatment of musculoskeletal conditions dates back from over a century ago and is the foundation for bone marrow grafting as today’s most used techniques for the treatment of non-union fractures[ 105 - 107 ] and osteochondral healing[ 90 , 91 , 108 , 109 ]. Newer methods based on the original grafting studies aim at providing means for cells from the subchondral bone marrow to reach the osteochondral defect through microfracture or subchondral bone drilling[ 109 - 113 ].…”

Section: Bone Marrow Mononuclear Cells As a Therapeutic Source Of Healthy Macrophagesmentioning

confidence: 99%

Bone marrow mononuclear cells for joint therapy: The role of macrophages in inflammation resolution and tissue repair

Menarim¹,

MacLeod²,

Dahlgren³

2021

WJSC

View full text Add to dashboard Cite

Osteoarthritis (OA) is the most prevalent joint disease causing major disability and medical expenditures. Synovitis is a central feature of OA and is primarily driven by macrophages. Synovial macrophages not only drive inflammation but also its resolution, through a coordinated, simultaneous expression of pro- and anti-inflammatory mechanisms that are essential to counteract damage and recover homeostasis. Current OA therapies are largely based on anti-inflammatory principles and therefore block pro-inflammatory mechanisms such as prostaglandin E 2 and Nuclear factor-kappa B signaling pathways. However, such mechanisms are also innately required for mounting a pro-resolving response, and their blockage often results in chronic low-grade inflammation. Following minor injury, macrophages shield the damaged area and drive tissue repair. If the damage is more extensive, macrophages incite inflammation recruiting more macrophages from the bone marrow to maximize tissue repair and ultimately resolve inflammation. However, sustained damage and inflammation often overwhelms pro-resolving mechanisms of synovial macrophages leading to the chronic inflammation and related tissue degeneration observed in OA. Recently, experimental and clinical studies have shown that joint injection with autologous bone marrow mononuclear cells replenishes inflamed joints with macrophage and hematopoietic progenitors, enhancing mechanisms of inflammation resolution, providing remarkable and long-lasting effects. Besides creating an ideal environment for resolution with high concentrations of interleukin-10 and anabolic growth factors, macrophage progenitors also have a direct role in tissue repair. Macrophages constitute a large part of the early granulation tissue, and further transdifferentiate from myeloid into a mesenchymal phenotype. These cells, characterized as fibrocytes, are essential for repairing osteochondral defects. Ongoing “omics” studies focused on identifying key drivers of macrophage-mediated resolution of joint inflammation and those required for efficient osteochondral repair, have the potential to uncover ways for developing engineered macrophages or off-the-shelf pro-resolving therapies that can benefit patients suffering from many types of arthropaties, not only OA.

show abstract

Section: Bone Marrow Mononuclear Cells As a Therapeutic Source Of Healthy Macrophagesmentioning

confidence: 99%

Bone marrow mononuclear cells for joint therapy: The role of macrophages in inflammation resolution and tissue repair

Menarim¹,

MacLeod²,

Dahlgren³

2021

WJSC

View full text Add to dashboard Cite

show abstract

Lo sociocultural desde la perspectiva biomédica. Una revisión de publicaciones en torno al tema

Martínez

2008

regsoc

View full text Add to dashboard Cite

La gama de temas y problemas relacionados de alguna manera con lo "sociocultural" en la literatura biomédica amerita ser explorada. Se presenta como material de apoyo un metaanálisis sobre 998 referencias biomédicas de artículos que aluden explícitamente a lo "sociocultural" entre 1963 y 2006, las cuales se han ido incrementando constantemente en la literatura biomédica a partir de 1975. Se analizan con mayor detenimiento algunos estudios relativos a México o a conjuntos sociales de origen mexicano, destacando y ejemplificando diversas implicaciones y alcances en el uso biomédico de dicho término. Todas las referencias fueron agrupadas por áreas temáticas, resaltándose un patrón diferencial en las patologías que motivan la alusión biomédica a lo "sociocultural". Las citas se presentan luego organizadas temáticamente para su consulta. La dimensión sociocultural del proceso salud/enfermedad/atención suscita diversas aproximaciones en la literatura biomédica, desde alusiones muy generales hasta caracterizaciones operativas que derivan en recomendaciones concretas, constituyendo un referente de utilidad en el proceso de definición de una posible epidemiología sociocultural.

show abstract

Re: “Sex Difference in the Effects of Sociocultural Status on Diabetes and Cardiovascular Risk Factors in Mexican Americans”

Cited by 2 publications

References 0 publications

Bone marrow mononuclear cells for joint therapy: The role of macrophages in inflammation resolution and tissue repair

Bone marrow mononuclear cells for joint therapy: The role of macrophages in inflammation resolution and tissue repair

Lo sociocultural desde la perspectiva biomédica. Una revisión de publicaciones en torno al tema

Contact Info

Product

Resources

About