Re: Predictors of mortality for patients with COVID-19 pneumonia caused by SARSCoV-2: a prospective cohort study

Yang, Haijun; Zhang, Yanmei; Yang, Min; Huang, Xing

doi:10.1183/13993003.02439-2020

Cited by 27 publications

(18 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We report worse prognosis among older adults presenting with MIN, even without myocardial necrosis, during the acute episode of SARS-CoV-2 infection. MIN led to a worse prognosis with more severe clinical presentation, prolonged time to recovery, and higher mortality rates among older adults, as had been reported in other series (11,12). We found age, male gender and pre-existing cardiovascular disease to be key factors associated with higher prevalence of MIN.…”

Section: Discussionsupporting

confidence: 80%

Prevalence and Prognostic Value of Myocardial Injury in the Initial Presentation of SARS-CoV-2 Infection among Older Adults

Arnau-Barrés

Pascual-Dapena

López-Montesinos

et al. 2021

Preprint

View full text Add to dashboard Cite

Myocardial involvement during SARS-CoV-2 infection has been reported in many prior publications. Data about this condition in older adults is scarce especially its role in clinical prognosis. We aim to study the prevalence and the clinical implications of acute myocardial injury (MIN) during SARS-CoV-2 infection, particularly in older patients.MethodsLongitudinal observational study where all consecutive adult patients admitted to a COVID-19 unit between March to April 2020 were included. Those patients aged ≥65 were considered as older patients. MIN was defined as at least 1 high-sensitive troponin (hs-TnT) concentration above the 99th percentile upper reference limit with different sex-cutoff.ResultsAmong the 634 patients admitted during the period of observation 365(58%) had evidence of MIN (hs-TnT>14 pg/mL), and among those 224(61%) were older adults. Individuals with acute MIN were more prone to be older, had more comorbidities, more functional decline at admission, and higher inflammatory parameters. Among older adults, MIN was associated with longer time to recovery compared to those without MIN [13 days(IQR 6-21) vs 9 days(IQR 5-17);p<0.001 repectively. In-hospital mortality was significantly higher in older adults with MIN at admission vs those without MIN [71(31%) vs 11(12%);p<0.001]. In a logistic regression model adjusting by age, sex, severity and Charlson comorbidity index the OR for in-hospital mortality was 2.1 (95% CI:1.02-4.42;p=0.043) among those older adults with MIN at presentation.ConclusionMIN is frequent in individuals with SARS-CoV-2 infection, especially in older adults and in patients with pre-existing comorbidities and with higher inflammatory levels. Older adults with acute myocardial injury had greater time to clinical recovery, more severe presentation of the disease and higher odds of in-hospital mortality.

show abstract

Section: Discussionsupporting

confidence: 80%

Prevalence and Prognostic Value of Myocardial Injury in the Initial Presentation of SARS-CoV-2 Infection among Older Adults

Arnau-Barrés

Pascual-Dapena

López-Montesinos

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…We found a 17.2% in-hospital mortality in this cohort, formed by patients admitted with COVID-19 pneumonia in 8 tertiary Galician hospitals during the peak of the outbreak in [11]. These rates are lower than the one we observed, but it is worth to mention that not all patients included in those studies were diagnosed as having pneumonia.…”

Section: Mortality and Comparison With Other Seriescontrasting

confidence: 61%

COVID-19 pneumonia in Galicia (Spain): Impact of prognostic factors and therapies on mortality and need for mechanical ventilation

et al. 2021

View full text Add to dashboard Cite

Introduction This study was aimed to identify risk factors associated with unfavorable outcomes (composite outcome variable: mortality and need for mechanical ventilation) in patients hospitalized in Galicia with COVID-19 pneumonia. Methods Retrospective, multicenter, observational study carried out in the 8 Galician tertiary hospitals. All Patients admitted with confirmed COVID-19 pneumonia from 1st of March to April 24th, 2020 were included. A multivariable logistic regression analysis was performed in order to identify the relationship between risk factors, therapeutic interventions and the composite outcome variable. Results A total of 1292 patients (56.1% male) were included. Two hundred and twenty-five (17.4%) died and 327 (25.3%) reached the main outcome variable. Age [odds ratio (OR) = 1.03 (95% confidence interval (CI): 1.01–1.04)], CRP quartiles 3 and 4 [OR = 2.24 (95% CI: 1.39–3.63)] and [OR = 3.04 (95% CI: 1.88–4.92)], respectively, Charlson index [OR = 1.16 (95%CI: 1.06–1.26)], SaO2 upon admission [OR = 0.93 (95% CI: 0.91–0.95)], hydroxychloroquine prescription [OR = 0.22 (95%CI: 0.12–0.37)], systemic corticosteroids prescription [OR = 1.99 (95%CI: 1.45–2.75)], and tocilizumab prescription [OR = 3.39 (95%CI: 2.15–5.36)], significantly impacted the outcome. Sensitivity analysis using different alternative logistic regression models identified consistently the ratio admissions/hospital beds as a predictor of the outcome [OR = 1.06 (95% CI: 1.02–1.11)]. Conclusion These findings may help to identify patients at hospital admission with a higher risk of death and may urge healthcare authorities to implement policies aimed at reducing deaths by increasing the availability of hospital beds.

show abstract

“…Troponin, myoglobin, C-reactive protein, serum ferritin, and IL-6 expression levels were higher in patients who had died from COVID-19 than in those who had died of other reasons. COVID-19 patients have a high inflammatory load, which causes a spike in cardiac myocarditis-related diseases 83 . In a previous study, a novel CoV that uses ACE-2 inside cells, SARS-CoV, was detected in the heart.…”

Section: Effects Of Covid-19 On the Cardiovascular Systemmentioning

confidence: 99%

Harmful Effects of COVID-19 on Major Human Body Organs: A Review

Chowdhury¹,

Mas-ud²,

Ali³

et al. 2021

J Pure Appl Microbiol

View full text Add to dashboard Cite

The world experienced the outbreak of a new pandemic disease in 2019, known as coronavirus (CoV) disease 2019 (COVID-19), which is caused by the novel severe acute respiratory syndrome-CoV-2 (SARS-CoV-2). The respiratory system is the organ system most commonly affected by COVID-19; however, several other organ systems have been reported to be affected. The SARS-CoV-2 RNA found in infected stub samples can cause lung contagion by binding to the angiotensin-converting enzyme-2 (ACE-2) receptor of the alveolar epithelial cells. The gut microbiota (GM) promote immunity, indicating that the alignment of the microbiota and corresponding metabolic processes in COVID-19 can help to identify novel biomarkers and new therapeutic targets for this disease. The cause of kidney damage in COVID-19 patients is possibly multifactorial, involving a complex mechanism that involves complement dysregulation and thrombotic microangiopathy, as well as the occurrence of a “cytokine storm” syndrome, which are immune responses that are abandoned and dysfunctional with unfavorable prognosis in severe COVID-19 cases. Furthermore, COVID-19 involves a continuous proliferation and activation of macrophages and lymphocytes. SARS-CoV-2 can also bind to the ACE-2 receptor expressed in the cerebral capillary endothelial cells that can invade the blood-brain wall, to penetrate the brain parenchyma. However, in the ongoing pandemic, there has been a surge in studies on a wide range of topics, including causes of respiratory failure, asymptomatic patients, intensive care patients, and survivors. This review briefly describes the damaging effects of COVID-19 on vital human organs and the inhibitory function of the ACE-2 receptor on the GM, which causes gut dysbiosis, and thus, this review discusses topics that have an opportunity for further investigation.

show abstract

Re: Predictors of mortality for patients with COVID-19 pneumonia caused by SARSCoV-2: a prospective cohort study

Cited by 27 publications

References 2 publications

Prevalence and Prognostic Value of Myocardial Injury in the Initial Presentation of SARS-CoV-2 Infection among Older Adults

Prevalence and Prognostic Value of Myocardial Injury in the Initial Presentation of SARS-CoV-2 Infection among Older Adults

COVID-19 pneumonia in Galicia (Spain): Impact of prognostic factors and therapies on mortality and need for mechanical ventilation

Harmful Effects of COVID-19 on Major Human Body Organs: A Review

Contact Info

Product

Resources

About

Re: Predictors of mortality for patients with COVID-19 pneumonia caused by SARSCoV-2: a prospective cohort study

Cited by 27 publications

References 2 publications

Prevalence and Prognostic Value of Myocardial Injury in the Initial Presentation of&nbsp;SARS-CoV-2 Infection&nbsp;among Older Adults

Prevalence and Prognostic Value of Myocardial Injury in the Initial Presentation of&nbsp;SARS-CoV-2 Infection&nbsp;among Older Adults

COVID-19 pneumonia in Galicia (Spain): Impact of prognostic factors and therapies on mortality and need for mechanical ventilation

Harmful Effects of COVID-19 on Major Human Body Organs: A Review

Contact Info

Product

Resources

About

Prevalence and Prognostic Value of Myocardial Injury in the Initial Presentation of SARS-CoV-2 Infection among Older Adults

Prevalence and Prognostic Value of Myocardial Injury in the Initial Presentation of SARS-CoV-2 Infection among Older Adults