Re: Morgan R. Pokorny, Maarten de Rooij, Earl Duncan, et al. Prospective Study of Diagnostic Accuracy Comparing Prostate Cancer Detection by Transrectal Ultrasound–Guided Biopsy Versus Magnetic Resonance (MR) Imaging with Subsequent MR-guided Biopsy in Men Without Previous Prostate Biopsies. Eur Urol 2014;66:22–9

Shanmugabavan, Yaalini; Guillaumier, Stephanie; Ahmed, Hashim U.

doi:10.1016/j.eururo.2014.08.065

Cited by 2 publications

(1 citation statement)

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“…Whether needle biopsy should be performed for a PI-RADS score of 3 and the positive rate of needle biopsy were not satisfactory. A 2016 multicenter prospective study showed that the detection rates of PCa were 13%, 31%, and 71% for lesions with a PI-RADS score greater than or equal to 3, respectively (16); other studies have made similar arguments (17-19). Interestingly, a study showed that for PI-RADS3 patients, dividing them into low-risk and high-risk groups according to the 0.5 ml threshold of lesion volume may help physicians make clinical decisions, but there is no large-scale central study to confirm this, and studies are mostly limited to the T1-2 clinical stage (20).…”

Section: Discussionmentioning

confidence: 90%

Study of iron metabolism based on T2* mapping sequences in PI-RADS 3 prostate lesions

et al. 2023

Front. Oncol.

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IntroductionProstate cancer is one of the most common malignant tumors in Chinese men, which is rich in iron metabolic activity and is closely related to all stages of prostate cancer progression. Since the current diagnostic methods are insufficient, we aimed to evaluate the value of quantitative T2 star values from the T2* mapping sequences in multiparametric magnetic resonance imaging (mpMRI) in the diagnosis and grading of PI-RADS 3 prostate cancer (PCa).MethodsWe prospectively enrolled patients with PCa or benign prostatic hyperplasia (BPH) admitted to our hospital from January 2021 to November 2022. Imaging indicators, including the T2* value and apparent diffusion coefficient (ADC) value, were collected, and enzyme-linked immunosorbent assays (ELISAs) were used to measure the levels of proteins involved in iron metabolism in the patients. ROC curves were drawn to explore whether the T2* value could be used for the diagnosis and grading of PCa.ResultsWe found that three iron metabolism indexes, ferritin, hepcidin, and the ferric ion (Fe), and the T2* value were significantly different between the PCa group and BPH group and between the low International Society of Urology Pathology (ISUP) group (ISUP ≤ 2) and the high ISUP group (ISUP>2). Additionally, there was a significant correlation between the levels of these three indicators and the T2* value. Further ROC analysis showed that the levels of iron metabolism-related indexes and T2* values performed well in diagnosing and grading PCa.DiscussionThe T2* value has good value in detecting and predicting the grade of prostate cancer and can reflect the iron metabolism of the tumor, which could provide a foundation for the diagnosis and grading of PCa in the future.

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Section: Discussionmentioning

confidence: 90%