Re: Monitoring of Aromatic Amine Exposures in Workers at a Chemical Plant With a Known Bladder Cancer Excess

Stephens, Ellen R.

doi:10.1093/jnci/89.10.734-a

Cited by 1 publication

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“…The conclusions deduced from this study were questioned by other scientists. − The criticsm emphasized that the genetic lesions were probably caused by other chemicals or arylamines (e.g., 4ABP and 2NA) present 20 years ago. Ward answered that also 20 years ago 2MA was the main chemical used in a chemical factory.…”

Section: Biomonitoring Of Urinary Metabolites and Of Hb-adducts In Th...mentioning

confidence: 83%

Hemoglobin Adducts and Urinary Metabolites of Arylamines and Nitroarenes

Sabbioni

2017

Chem. Res. Toxicol.

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Arylamines and nitroarenes are intermediates in the production of pharmaceuticals, dyes, pesticides, and plastics and are important environmental and occupational pollutants. N-Hydroxyarylamines are the toxic common intermediates of arylamines and nitroarenes. N-Hydroxyarylamines and their derivatives can form adducts with hemoglobin (Hb-adducts), albumin, DNA, and tissue proteins in a dose-dependent manner. Most of the arylamine Hb-adducts are labile and undergo hydrolysis in vitro, by mild acid or base, to form the arylamines. According to current knowledge of arylamine adduct-formation, the hydrolyzable fraction is derived from the reaction products of the arylnitroso derivatives that yield arylsulfinamide adducts with cysteine. Hb-adducts are markers for the bioavailability of N-hydroxyarylamines. Hb-adducts of arylamines and nitroarenes have been used for many biomonitoring studies for over 30 years. Hb-adducts reflect the exposure history of the last four months. Biomonitoring of urinary metabolites is a less invasive process than biomonitoring blood protein adducts, and urinary metabolites have served as short-lived biomarkers of exposure to these hazardous chemicals. However, in case of intermittent exposure, urinary metabolites may not be detected, and subjects may be misclassified as nonexposed. Arylamines and nitroarenes and/or their metabolites have been measured in urine, especially to monitor the exposure of workers. This review summarizes the results of human biomonitoring studies involving urinary metabolites and Hb-adducts of arylamines and nitroarenes. In addition, studies about the relationship between Hb-adducts and diseases are summarized.

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Section: Biomonitoring Of Urinary Metabolites and Of Hb-adducts In Th...mentioning

confidence: 83%

Hemoglobin Adducts and Urinary Metabolites of Arylamines and Nitroarenes

Sabbioni

2017

Chem. Res. Toxicol.

View full text Add to dashboard Cite

show abstract

Re: Monitoring of Aromatic Amine Exposures in Workers at a Chemical Plant With a Known Bladder Cancer Excess

Cited by 1 publication

References 6 publications

Hemoglobin Adducts and Urinary Metabolites of Arylamines and Nitroarenes

Hemoglobin Adducts and Urinary Metabolites of Arylamines and Nitroarenes

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