Re-irradiation in Gynaecological Malignancies: A Review

Sadozye, Azmat

doi:10.1016/j.clon.2017.11.013

Cited by 26 publications

(15 citation statements)

References 20 publications

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“…Grade 3+ toxicity was felt to be acceptable (34%) and patients who were able to undergo subsequent surgery had especially promising LC and OS. In addition to locally recurrent rectal cancer, reRT is also feasible for anal canal, gynecologic, prostate, and other abdominopelvic cancers (7,(20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%

Dose-Escalated Magnetic Resonance Image–Guided Abdominopelvic Reirradiation With Continuous Intrafraction Visualization, Soft Tissue Tracking, and Automatic Beam Gating

Chuong

Bryant

Herrera

et al. 2022

Advances in Radiation Oncology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Discussionmentioning

confidence: 99%

Dose-Escalated Magnetic Resonance Image–Guided Abdominopelvic Reirradiation With Continuous Intrafraction Visualization, Soft Tissue Tracking, and Automatic Beam Gating

Chuong

Bryant

Herrera

et al. 2022

Advances in Radiation Oncology

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“…According to previous studies, grade ≥2 late complications of RT for recurrent patients are usually tolerable, with an approximate rate lower than 15% ( 21 , 23 , 27 ). It has been reported that re-irradiation might increase the risk of complication up to 15%–20% ( 12 , 28 ). Compared with previous studies, our study presented an acceptable rate of grade ≥2 late complications (15.6%), which can also be attributed to the high RT dose in our treatment regimens.…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy for Vaginal Recurrences of Cervical Cancer in Patients After Prior Surgery: Analysis of Effect and Prognostic Factors

et al. 2021

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ObjectiveThe role of salvage radiotherapy (RT) in the treatment for vaginal recurrence of cervical cancer in patients after prior surgery remains controversial. The aim of this study was to evaluate the efficacy and toxicity of salvage RT and explore prognostic factors associated with the survival after recurrence.MethodsPatients with cervical cancer, treated for vaginal recurrences at Peking Union Medical College Hospital between July 2011 and November 2019, were identified. All the patients underwent prior surgery for primary tumor and received salvage RT including external beam radiotherapy (EBRT), brachytherapy (BT), or both. The irradiation field and dose depended on the conditions of patients. Recurrence patterns were classified into four categories according to the site of recurrence. Prognostic factors on the overall survival (OS), progression-free survival (PFS), and local control (LC) were analyzed, and late toxicity was evaluated.ResultsA total of 141 patients were included in the analysis, with a median follow-up time of 40.8 months. The estimated 5-year OS, PFS, and LC rates were 81%, 75%, and 87%, respectively. In multivariate analysis, endovaginal recurrence and no irradiation history were favorable prognostic factors associated with OS (all p < 0.05), PFS (all p < 0.05), and LC (all p < 0.05). The area under the receiver operating characteristic (ROC) curve (AUC) of the recurrence pattern is larger than the stage of primary tumor (0.734 vs. 0.670).ConclusionsRT was an effective treatment with tolerable toxicity for vaginal recurrences of cervical cancer in patients with prior surgery. Recurrence pattern and irradiation history were important prognostic factors.

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“…The pelvis is a major site for ReRT-BT in the Japanese cohort. It is natural because gynecological and prostate lesions could be good candidates not only for fresh BT but also for ReRT-BT with accumulated evidence (5)(6)(7)(8)(9). However, the fact that low-volume head neck tumor could be a good candidate to curative ReRT-BT is well documented and has a long history (12)(13)(14)23); however, fewer cases are salvaged by ReRT-BT in Japan.…”

Section: Such Treatment Decisions Must Be Handled Only By Teamsmentioning

confidence: 99%

A national surveillance study of the current status of reirradiation using brachytherapy in Japan

et al. 2021

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This study aimed to explore the current status and pattern of practice for reirradiation using brachytherapy (ReRT-BT) through a survey in Japan. MATERIALS AND METHODS:We distributed an e-mail-based questionnaire to 153 institutions equipped with high-dose-rate brachytherapy facilities. RESULTS: We received responses from 76 institutions (49.7%). Forty-three of these institutions performed ReRT-BT and 42 institutions (55%) performed ReRT-BT during 2009e2018. However, 29 of the 42 institutions (69%) reported difficulty in obtaining ReRT-BT case information from their respective databases. Almost all the institutions encountered insufficient database system to extract details about the ReRT-BT cases. Responses from 33 institutions included the number of ReRT-BT cases; this increased from 90 in the period 2009e2013 (institution median 5 0.5; 0e 16) to 172 in the period 2014e2018 (institution median 5 2; 0e26). Nine institutions had to perform ReRT-BT for more than one case per year. The major location for cancer treatment was the pelvis (94%), followed by the head and neck (5%) and others (1%). In six site-specific scenarios, barring uterine corpus cancer recurrence, more than 90% of radiation oncologists agreed to perform ReRT-BT, whereas other areas (head and neck, prostate, and rectal cancer) gained 16e37% agreement. CONCLUSIONS: This decade saw an increase in the number of ReRT-BT cases in Japan and radiation oncologists' interest in ReRT-BT as a viable therapeutic option. However, scarce availability, immature education system, and insufficient database system are barriers to further consensus building.

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Re-irradiation in Gynaecological Malignancies: A Review

Cited by 26 publications

References 20 publications

Dose-Escalated Magnetic Resonance Image–Guided Abdominopelvic Reirradiation With Continuous Intrafraction Visualization, Soft Tissue Tracking, and Automatic Beam Gating

Dose-Escalated Magnetic Resonance Image–Guided Abdominopelvic Reirradiation With Continuous Intrafraction Visualization, Soft Tissue Tracking, and Automatic Beam Gating

Radiotherapy for Vaginal Recurrences of Cervical Cancer in Patients After Prior Surgery: Analysis of Effect and Prognostic Factors

A national surveillance study of the current status of reirradiation using brachytherapy in Japan

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