Re: HPV vaccination for penile cancer eradication: cost effectiveness view

Joob, Beuy; Wiwanitkti, Viroj

doi:10.1590/s1677-5538.ibju.2018.0659

Cited by 1 publication

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References 2 publications

(2 reference statements)

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“…Studies also found that the low-risk type is the main infection type of CA in China at present (Suzuki et al, 2014), and the causal relationship between other types of HPV and CA need further study (Hawkins et al, 2013). CA patients infected with HPV 16 and 18 may still develop into cancer because HPV 16 and 18 infections can lead to cervical cancer and penile cancer (de Araújo et al, 2018; Joob and Wiwanitkti, 2019; Sakamoto et al, 2019). Although low-risk HPV infection cannot directly lead to cancer, CA patients are often accompanied with other sexually transmitted diseases (AIDS, syphilis, gonorrhea, chlamydia, and mycoplasma, genital herpes, etc.…”

Section: Introductionmentioning

confidence: 99%

Patients With LR-HPV Infection Have a Distinct Vaginal Microbiota in Comparison With Healthy Controls

Yang

Wang

Pei

et al. 2019

Front. Cell. Infect. Microbiol.

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Condyloma acuminatum (CA) is a benign epithelium hyperplasia mainly caused by human papillomavirus (HPV), which is now the second most common viral sexually transmitted infection (STI) in China. In total, 90% of CA patients are caused by the low-risk HPV 6 and 11. Aside from low-risk HPV infection there are likely other factors within the local microenvironment that contribute to CA and there has been related research before. In this study, 62 vaginal specimens were analyzed using 16S rRNA gene sequencing. The diversity of the vaginal microbiota was higher and the composition was different with LR-HPV infection. While the relative abundance of dominant Firmicutes was lower, Actinobacteria, Proteobacteria, and Fusobacteria phyla were significantly higher; at the genus level Gardnerella, Bifidobacterium, Sneathia, Hydrogenophilus, Burkholderia, and Atopobium were higher. This study firstly confirmed a more accurate and comprehensive understanding of the relationship between low-risk HPV infection and vaginal microbiota, in order to provide a theoretical basis for further research on the occurrence and development of CA.

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