Re: High nevus counts confer a favorable prognosis in melanoma patients by <scp>S</scp> ribero and co‐workers, published in the <i><scp>I</scp>nternational <scp>J</scp>ournal of <scp>C</scp>ancer</i>, 2015 (online 21 march 2015)

Autier, Philippe; Funck‐Brentano, Elisa; Aegerter, Philippe; Boniol, Mathieu; Saïag, Philippe

doi:10.1002/ijc.29648

Cited by 5 publications

(5 citation statements)

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“…A previous NOWAC study found that fair pigmentation was associated with thinner melanomas ( 11 ) and discussed whether this was due to increased melanoma awareness among those with high-risk phenotypes. Others have also suggested that lower melanoma-specific mortality among those with high-risk phenotypes may result from increased screening and overdiagnosis, resulting in thinner, less life-threatening tumors ( 17 ). As indications of higher risk of melanoma death among women with darker pigmentation and nevi were maintained among those with tumors > 1 mm, the current findings indicate that there may be biological mechanisms that might improve outcomes among those with high-risk phenotypes beyond awareness.…”

Section: Discussionmentioning

confidence: 99%

“…Skin self-examination (SSE) and melanoma awareness may be associated with lower melanoma-specific mortality ( 15 , 16 ). Given that SSE is often recommended for people with many nevi, increased awareness may result in an earlier stage at diagnosis ( 17 ) and improved survival. Similarly, both freckling and red/blonde hair colour and, by association, poor tanning ability ( 1 ), are associated with increased melanoma awareness in women ( 18 ), which may affect survival outcomes.…”

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confidence: 99%

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Nevus Count, Pigmentary Characteristics, and Melanoma-specific Mortality among Norwegian Women with Melanoma >1.0 mm Thick

et al. 2023

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Little is known about if and how nevi and pigmentation are associated with melanoma-specific mortality. However, increased melanoma awareness in people with lighter pigmentation and many nevi may result in earlier diagnosis of thinner less-lethal tumors. The aim of this study was to investigate associations between nevus count (asymmetrical > 5 mm and small symmetrical), pigmentary characteristics (hair colour, eye colour, skin colour, freckling, pigmentary score), and melanoma-specific mortality in subjects with melanomas > 1 mm. Data from the Norwegian Women and Cancer cohort, established in 1991, with complete follow-up of melanoma patients until 2018 through the Cancer Registry of Norway, were used to estimate hazard ratios with 95% confidence intervals for the associations between nevus count, pigmentary characteristics, and melanoma-specific mortality, stratified by tumor thickness using Cox regression. Estimated hazard ratios consistently indicated a higher risk of melanoma death for those with darker vs lighter pigmentary characteristics in patients with tumors > 1.0–2.0 mm and > 2.0 mm thick (e.g. pigmentary score hazard ratio 1.25, 95% confidence interval (0.74–2.13)). Among women with melanomas > 1.0 mm thick, lighter pigmentation and asymmetrical nevi may be associated with lower melanoma-specific mortality, suggesting that factors that increase the risk of melanoma may also be associated with decreased risk of death from melanoma.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Nevus Count, Pigmentary Characteristics, and Melanoma-specific Mortality among Norwegian Women with Melanoma >1.0 mm Thick

et al. 2023

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“…As noted in our study above, higher nevus counts may be associated with a lower chance of dying from melanoma [ 14 ]. It is possible however that those with large numbers of naevi are subjected to increased screening, which may lead to overdiagnosis and greater survival relative to those with fewer moles [ 57 ]. However, as already indicated, increased screening is not associated with MSS [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Higher polygenic risk for melanoma is associated with improved survival in a high ultraviolet radiation setting

et al. 2022

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Background The role of germline genetic factors in determining survival from cutaneous melanoma (CM) is not well understood. Objective To perform a genome-wide association study (GWAS) meta-analysis of melanoma-specific survival (MSS), and test whether a CM-susceptibility polygenic risk score (PRS) is associated with MSS. Methods We conducted two Cox proportional-hazard GWAS of MSS using data from the Melanoma Institute Australia, a high ultraviolet (UV) radiation setting (MIA; 5,762 patients with melanoma; 800 melanoma deaths) and UK Biobank (UKB: 5,220 patients with melanoma; 241 melanoma deaths), and combined them in a fixed-effects meta-analysis. Significant (P < 5 × 10–8) results were investigated in the Leeds Melanoma Cohort (LMC; 1,947 patients with melanoma; 370 melanoma deaths). We also developed a CM-susceptibility PRS using a large independent GWAS meta-analysis (23,913 cases, 342,870 controls). The PRS was tested for an association with MSS in the MIA and UKB cohorts. Results Two loci were significantly associated with MSS in the meta-analysis of MIA and UKB with lead SNPs rs41309643 (G allele frequency 1.6%, HR = 2.09, 95%CI = 1.61–2.71, P = 2.08 × 10–8) on chromosome 1, and rs75682113 (C allele frequency 1.8%, HR = 2.38, 95%CI = 1.77–3.21, P = 1.07 × 10–8) on chromosome 7. While neither SNP replicated in the LMC, rs75682113 was significantly associated in the combined discovery and replication sets. After adjusting for age at diagnosis, sex and the first ten principal components, a one standard deviation increase in the CM-susceptibility PRS was associated with improved MSS in the discovery meta-analysis (HR = 0.88, 95% CI = 0.83–0.94, P = 6.93 × 10–5; I2 = 88%). However, this was only driven by the high UV setting cohort (MIA HR = 0.84, 95% CI = 0.78–0.90). Conclusion We found two loci potentially associated with MSS. Increased genetic susceptibility to develop CM is associated with improved MSS in a high UV setting.

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“…As noted in our study above, higher nevus counts may be associated with a lower chance of dying from melanoma (Ribero et al 2015). It is possible however that those with large numbers of naevi are subjected to increased screening, which may lead to overdiagnosis and greater survival relative to those with fewer moles (Autier et al 2015). However, as already indicated, increased screening is not associated with MSS (Watts et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Higher polygenic risk for melanoma is associated with improved survival

Seviiri

Scolyer

Bishop

et al. 2022

Preprint

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Background: Although there are well-known prognostic factors for survival from cutaneous melanoma (CM) such as primary tumour thickness and stage of the tumour at diagnosis, the role of germline genetic factors in determining survival is not well understood. Objective: To perform a genome-wide association study (GWAS) meta-analysis of melanoma-specific survival (MSS), and test whether a CM-susceptibility polygenic risk score (PRS) is associated with MSS. Methods: We conducted two Cox proportional-hazard GWAS of MSS using data from the Melanoma Institute Australia (MIA; 5,762 patients with melanoma; 800 deaths from melanoma) and UK Biobank (UKB: 5,220 patients with melanoma; 241 deaths from melanoma). The GWAS were adjusted for age, sex and the first ten genetic principal components, and combined in a fixed-effects inverse-variance-weighted meta-analysis. Significant (P < 5 X 10-8) results were investigated in the Leeds Melanoma Cohort (LMC; 1,947 patients with melanoma; 370 melanoma deaths). We also developed a CM-susceptibility PRS using a large independent GWAS meta-analysis (23,913 cases, 342,870 controls). The PRS was tested for an association with MSS in the MIA and UKB cohorts, with replication in the LMC. Results: Two loci were significantly associated with MSS in the meta-analysis of MIA and UKB with lead SNPs rs41309643 (G allele frequency 1.6%, hazard ratio [HR] 2.09, 95% confidence interval [CI] 1.61-2.71, P=2.08 X 10-8) on chromosome 1, and rs75682113 (C allele frequency 1.8%, HR=2.38, 95% CI=1.77-3.21, P=1.07 X 10-8) on chromosome 7. While neither SNP replicated (P>0.05) in the LMC, rs75682113 was significantly associated in the combined discovery and replication sets and requires confirmation in additional cohorts. After adjusting for age at diagnosis, sex and the first ten principal components, a one standard deviation increase in the CM-susceptibility PRS was associated with improved MSS in the discovery meta-analysis (HR=0.88, 95% CI=0.83-0.94, P=6.93 X 10-5; I2=88%). The association with the PRS was not replicated (P > 0.05) in LMC, but remained significantly associated with MSS in the meta-analysis of the discovery and replication results. Conclusion: We found two loci potentially associated with MSS, and evidence that increased germline genetic susceptibility to develop CM may be associated with improved MSS.

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Re: High nevus counts confer a favorable prognosis in melanoma patients by S ribero and co‐workers, published in the International Journal of Cancer, 2015 (online 21 march 2015)

Cited by 5 publications

References 10 publications

Nevus Count, Pigmentary Characteristics, and Melanoma-specific Mortality among Norwegian Women with Melanoma >1.0 mm Thick

Nevus Count, Pigmentary Characteristics, and Melanoma-specific Mortality among Norwegian Women with Melanoma >1.0 mm Thick

Higher polygenic risk for melanoma is associated with improved survival in a high ultraviolet radiation setting

Higher polygenic risk for melanoma is associated with improved survival

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