RE: Familial Cancer Clustering of Urothelial Cancer: A Population-Based Case–Control Study

Hemminki, Kari; Yu, Hongyao; Hemminki, Otto; Sundquist, Jan

doi:10.1093/jnci/djy053

Cited by 1 publication

(1 citation statement)

References 6 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Code 1810 was used for bladder cancers and, of these, 98% are transitional cell carcinomas. 30 The code for ureter cancer was 1811. 31 Urethral cancer was not considered because of its rarity and late introduction of a specific diagnostic code.…”

Section: Methodsmentioning

confidence: 99%

Bladder and upper urinary tract cancers as first and second primary cancers

Zheng

Sundquist

et al. 2021

Cancer Reports

Self Cite

View full text Add to dashboard Cite

Background: Previous population-based studies on second primary cancers (SPCs) in urothelial cancers have focused on known risk factors in bladder cancer patients without data on other urothelial sites of the renal pelvis or ureter.Aims: To estimate sex-specific risks for any SPCs after urothelial cancers, and in reverse order, for urothelial cancers as SPCs after any cancer. Such two-way analysis may help interpret the results. Methods:We employed standardized incidence ratios (SIRs) to estimate bidirectional relative risks of subsequent cancer associated with urothelial cancers. Patient data were obtained from the Swedish Cancer Registry from years 1990 through 2015.Results: We identified 46 234 urinary bladder cancers (75% male), 940 ureteral cancers (60% male), and 2410 renal pelvic cancers (57% male). After male bladder cancer, SIRs significantly increased for 9 SPCs, most for ureteral (SIR 41.9) and renal pelvic (17.2) cancers. In the reversed order (bladder cancer as SPC), 10 individual FPCs were associated with an increased risk; highest associations were noted after renal pelvic (21.0) and ureteral (20.9) cancers. After female bladder cancer, SIRs of four SPCs were significantly increased, most for ureteral (87.8) and pelvic (35.7) cancers. Female bladder, ureteral, and pelvic cancers associated are with endometrial cancer.

show abstract

Section: Methodsmentioning

confidence: 99%