Re‐exposure to beta cell autoantigens in pancreatic allograft recipients with preexisting beta cell autoantibodies

Abstract

T. (2015). Re-exposure to beta cell autoantigens in pancreatic allograft recipients with preexisting beta cell autoantibodies. Clinical Transplantation, 29(11), 991-996. http://doi.org/10.1111/ctr.12619Re-exposure to beta cell autoantigens in pancreatic allograft recipients with pre-existing beta cell autoantibodies. Re-exposure to beta cell autoantigens in pancreatic allograft recipients with pre-existing beta cell autoantibodies. Abstract:Re-exposure to beta cell autoantigens and its relevance in the presence of donor specific antibodies (DSA) in pancreas allograft recipients is not well known.Thirty-three patients requiring a pancreas transplant were enrolled in an IRB approved study.They underwent prospective monitoring for DSA and beta cell autoantibody (BCAA) levels to GAD65, Insulinoma-associated-antigen 2(IA-2), insulin (micro-IAA [mIAA]), and islet-specific zinc-transporter isoform-8 (ZnT8).Twenty-five (75.7%) had pre transplant BCAA. Twenty had a single antibody (mIAA n=15, GAD65 n=5); five had two or more BCAA (GAD65+mIAA n=2, GAD65+mIAA+IA-2 n=2,