Re-examination of therapeutic management of muscular dystrophies using a vascular smooth muscle-centered approach
Senthilkumar Preethy,
Naoki Yamamoto,
Shiro Ozasa
et al.
Abstract:In contrast to the long-standing focus on the pathophysiology of skeletal muscles in the
hunt for a cure for Duchenne muscular dystrophy (DMD), we opine that the malfunctioning of
dystrophin produced by vascular smooth muscle is a major contributor to the pathology of
the illness. We believe that a biological response modifier glucan (BRMG), which has been
shown in clinical studies of DMD to boost the expression of vascular smooth muscle
dystrophin and provide anti-fibrotic and anti-inflammatory effects, may p… Show more
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