"Re-evaluation of variants of uncertain significance in patients with hereditary arrhythmogenic disorders"
Sarah Martin,
Tina Jenewein,
Christof Geisen
et al.
Abstract:Background
Genetic diagnostics support the diagnosis of hereditary arrhythmogenic diseases, but variants of uncertain significance (VUS) complicate matters, emphasising the need for regular reassessment. Our study aims to reanalyse rare variants in different genes in order to decrease VUS diagnoses and thus improve risk stratification and personalized treatment for patients with arrhythmogenic disorders.
Methods
Genomic DNA was analysed using Sange… Show more
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