Re-evaluation of the intratesticular level of testosterone required for quantitative maintenance of spermatogenesis in the rat

Sharpe, Richard M.; Donachie, K.; Cooper, Irene

doi:10.1677/joe.0.1170019

Cited by 149 publications

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“…Our results indicated that plasma testosterone level had a significant positive correlation with faster TSL, which seems higher in BR bucks compared with NZW bucks. These results are in agreement with Sharpe et al (1988), who found that male sexual desire and spermatogenesis process depends on the action of testosterone. In contrast, NZW bucks had significantly higher plasma cortisol and T 3 than those recorded in BR bucks breed after heat stress.…”

Section: Discussionsupporting

confidence: 93%

Behavioral Activities, Physiological Body Reactions, Hematological Parameters and Hormonal Profiles for Bucks of New Zealand White and Baladi Red Rabbits Exposed to Short Term of High Temperature

Khalil¹,

Yaseen²,

Hamdy³

2015

Asian J. of Poultry Science

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This study was conducted to investigate the effect of acute short term heat exposure on behavioral activities, physiological body reactions, hematological parameters and hormonal profiles of New Zealand White (NZW) and Baladi Red (BR) bucks. Twenty male NZW and BR bucks were divided into two groups; natural winter climate of 19±1°C and 55±5%, Relative Humidity (RH) (control group) and the bucks in the other group were exposed to short term heat stress for 1 h at 37±0.5°C and 20±2% RH. The results indicated that, heat stress decreased (p#0.001) standing and walking behavior and increased (p#0.001) sitting behavior compared with these recorded under control temperature. Moreover, Respiration Rate (RR), Rectal Temperatures (RT) and Time of Sexual Libido (TSL) were significantly increased (p#0.001) following stress. Concentration of plasma testosterone and T 3 were significantly reduced (p#0.001) and cortisol were significantly increased after submission to stress. The RBCs, WBCs, Hb, PCV values were insignificantly reduced and lymphocyte was significantly reduced after stress. In contrast, neutrophils, Neutrophils/Lymphocytes (N/L) ratio were increased (p#0.05) and monocytes were insignificantly increased after the end of heat stress. On the other hand, breeds of rabbit had significant effects on most of the studied traits, especially after heat exposure. The BR bucks were significantly superior; RBCs, WBCs, neutrophils, N/L ratio and monocytes than those recorded in NZW bucks after heat stress. Also, plasma concentration of testosterone were significantly higher but cortisol and T 3 were significantly lower (p#0.05) in BR bucks than those estimated in NZW bucks. Moreover, BR bucks had insignificantly higher walking and lower standing behavior than those recorded in NZW bucks. Also, RR was significantly higher (p#0.001), but RT and TSL were significantly lower (p#0.001) in BR bucks than those recorded in the NZW bucks. Furthermore, the results showed that there were prevalent significant (p#0.05) negative correlation between plasma level of cortisol and each of plasma level of testosterone, RBCs, WBCs counts, standing and walking behavior and significant (p#0.001) positive with RR, RT, TSL and time of sitting behavior. Current results explained that acute short term heat stress, negatively affected of internal environment of rabbit bucks which were reflected in their performance. Also, behavioral traits, sexual libido, hematological parameters and hormonal profile in BR bucks seem to be better than those recorded by NZW bucks after exposed heat stress, which may be explained, why BR breed had more tolerate to heat stress compared to exotic breeds.

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Section: Discussionsupporting

confidence: 93%

Behavioral Activities, Physiological Body Reactions, Hematological Parameters and Hormonal Profiles for Bucks of New Zealand White and Baladi Red Rabbits Exposed to Short Term of High Temperature

Khalil¹,

Yaseen²,

Hamdy³

2015

Asian J. of Poultry Science

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“…There were no significant differences in food intake and body weights during the experimental period among the 3 groups. Testicularfree TS Ievels Since it is well known that spermatogenesis depends on the action of TS (Sharpe et al, 1988), we measured the intra-testicular levels of TS in the RJ-fed hamsters. As shown in Fig.1, the long-term feeding of RJ resulted in an increase in the intra-testicular TS Ievels in a dose-dependent manner.…”

Section: Resultsmentioning

confidence: 99%

Effect of Royal Jelly Diet on the Testicular Function of Hamsters

Kohguchi¹,

Inoue²,

Ushio³

et al. 2004

FSTR

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To investigate the long-term effect of feeding royal jelly (RJ) on the testicular function, 32-week old male golden hamsters were fed diet containing RJ at doses of O ug/g diet (control), 50 ug/g diet or 500 ug/g diet for 12 weeks. At the end of the experiment, the hamsters were assessed for testicular function in terms of the amounts of intra-testicular free testosterone (TS) and histopathological changes. RJ diet groups showed higher TS Ievels and more intensive spermatogenesis than the control group in a dose-dependent manner. The intensity of spermatogenesis and TS Ievels in the 500 ug of RJ/g diet group showed significant differences ofp < 0.01 and p < 0.05, respectively, when compared with those in the control group. These results indicate that the long-term feeding of RJ inhibits the age-associated decline in the testicular function of male hamsters.

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“…The resulting testosterone concentrations, while supraphysiological at the higher doses as reflected by hypertrophy of the prostate (data not shown), are low intratesticularly (Sharpe et al, 1988) and it is possible that considerably higher levels of testosterone approaching those found intratesticularly are required to produce an effect. However, the in-vitro culture of segments of seminiferous tubules from hypophysectomized rats at testosterone concen¬ trations (100 ng/ml) similar to those found in rat interstitial fluid (Turner et al, 1984;Sharpe et al, 1988) does not modify inhibin production, in keeping with earlier findings with Sertoli cell (Bicsak et al, 1987;Toebosch et al, 1988;Morris et al, 1988) and seminiferous tubule (Gonzales et al, 1988) cultures. In contrast, the in-vivo administration of testosterone to intact animals results in a dose-related fall then rise (after 7 but not 13 weeks) of serum inhibin levels.…”

Section: Discussionmentioning

confidence: 93%

Effect of testosterone on serum immunoactive inhibin concentrations in intact and hypophysectomized male rats

Sun¹,

Robertson²,

Gonzales³

et al. 1989

Reproduction

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Summary. Intact and hypophysectomized rats were treated with graded doses of testosterone via subcutaneous Silastic implants over a 13-week period. Serum inhibin concentrations fell 50% (P < 0\m=.\001) after 2 weeks of hypophysectomy, remaining suppressed at this level for 13 weeks. The administration of testosterone to hypophysectomized rats (serum testosterone values 2\p=n-\12 ng/ml; control values 5\m=.\5 ng/ml) was without effect on serum inhibin values. In contrast, administration of testosterone to intact animals for 7 weeks resulted in an initial fall (P < 0\m=.\05) in inhibin levels to 50\p=n-\70%of controls then increasing to reach control levels at higher doses. Serum FSH concentrations were similarly biphasic with increasing dose of testosterone and values for these two hormones were significantly correlated (r = 0\m=.\44,P < 0\m=.\01).Segments of seminiferous tubules in culture from rats after various times of hypophysectomy showed a partly suppressed secretion of inhibin. The administration of testosterone did not modify inhibin production although inhibin production was sensitive to FSH.It is concluded that (1) serum inhibin concentrations are partly suppressed after hypophysectomy and testosterone has no effect on serum inhibin values; and (2) the suppression of serum inhibin in intact rats treated with increasing doses of testosterone is attributable to the concomitant fall in serum FSH concentrations.

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Re-evaluation of the intratesticular level of testosterone required for quantitative maintenance of spermatogenesis in the rat

Cited by 149 publications

References 0 publications

Behavioral Activities, Physiological Body Reactions, Hematological Parameters and Hormonal Profiles for Bucks of New Zealand White and Baladi Red Rabbits Exposed to Short Term of High Temperature

Behavioral Activities, Physiological Body Reactions, Hematological Parameters and Hormonal Profiles for Bucks of New Zealand White and Baladi Red Rabbits Exposed to Short Term of High Temperature

Effect of Royal Jelly Diet on the Testicular Function of Hamsters

Effect of testosterone on serum immunoactive inhibin concentrations in intact and hypophysectomized male rats

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