Re-evaluation of the biocompatibility of bioinert ceramics in vivo

Hayashi, Koichiro; Matsuguchi, Nobuyuki; Uenoyama, Kazuhide; Sugioka, Yôichi

doi:10.1016/0142-9612(92)90184-p

Cited by 60 publications

(44 citation statements)

References 13 publications

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“…The peak total length of the cement surface in the tibia and multiplying the value by 100. 28 When measuring the total length temperature and its time after the mixing for AWC(I0) and AWC(I/) were 80 ЊC at 6 h and 36 min and 85 ЊC of the cement surface, the area outside the tibia (i.e., the The SEM-EDX profiles of cross sections of the surfaces of both AWC(I0) and AWC(I/) showed that a Ca-P rich and with the inhibitor, the corresponding values were 134 ЊC at 4 h and 30 min and 136 ЊC at 5 h and 30 min, layer 15,18,19,21 had formed in addition to a thin apatite layer on the cement surface and that the Ca-P rich layer of respectively. Table I lists the total amount of heat generated in the AWC(I/) was narrower than that of AWC(I0) (Fig.…”

Section: Statistical Analysis Histological Examinationmentioning

confidence: 97%

Effect of polymerization reaction inhibitor on mechanical properties and surface reactivity of bioactive bone cement

Kobayashi

Nakamura

Kikutani

et al. 1998

J. Biomed. Mater. Res.

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We introduced an inhibitor to the polymerization reaction of bioactive bone cement (AWC) consisting of MgO-CaO-SiO2-P2O5-CaF2 apatite and wollastonite containing glass-ceramic powder and bisphenol-alpha-glycidyl methacrylate based resin, together with an increased amount of accelerator but without any prolongation of its setting time in order to improve the degree of polymerization and decrease the amount of incompletely polymerized monomers on the cement surface. A comparison was made between the AWC containing the inhibitor [AWC(I+)] and the AWC without it [AWC(I-)] with regard to setting parameters, mechanical properties, and surface reactivity in vitro and in vivo. The proportion of glass-ceramic powder added to the AWC was 70% (w/w). The total amount of heat generation and the peak temperature of the AWC(I+) during polymerization were slightly greater than those of the AWC(I-). The mechanical strength of AWC(I+) was higher than that of the AWC(I-) under wet conditions. In simulated body fluid, the width of the Ca-P rich layer on the surface of the AWC(I+) was less than that on the AWC(I-) after 28 days of immersion, although the rate of apatite formation on the top surface of the AWC(I+) was almost identical to that on the AWC(I-) surface. Histological examination using rat tibiae up to 26 weeks revealed that the bioactivity of the AWC(I+) was equivalent to that of the AWC(I-). Scanning electron microscopy and energy-dispersive X-ray microanalysis demonstrated that the Ca-P rich layer in the AWC(I+) was significantly narrower than that in the AWC(I-) at the same time points. These results indicate that introduction of the inhibitor improved the mechanical properties of the AWC and made the Ca-P rich layer narrower, but it had no adverse effect on bioactivity.

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Section: Statistical Analysis Histological Examinationmentioning

confidence: 97%

Effect of polymerization reaction inhibitor on mechanical properties and surface reactivity of bioactive bone cement

Kobayashi

Nakamura

Kikutani

et al. 1998

J. Biomed. Mater. Res.

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“…These studies showed that the CNT/alumina composite has biocompatibility and bone tissue compatibility similar to that of 25 alumina ceramic. Because ceramic materials are frequently used in areas adjacent to bone, long-term bone tissue compatibility tests at 12 and 24 weeks were performed [40,41]. Alumina ceramic combined with CNTs was shown to be stable for long periods in vivo.…”

Section: Discussionmentioning

confidence: 99%

Biocompatibility and Bone Tissue Compatibility of Alumina Ceramics Reinforced with Carbon Nanotubes

et al. 2012

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Aims: The addition of carbon nanotubes (CNTs) remarkably improves the mechanical characteristics of base materials. CNT/alumina ceramic composites are expected to be highly functional biomaterials useful in a variety of medical fields. Biocompatibility and bone tissue compatibility were studied for the application of CNT/alumina composites as biomaterials.Methods & results: Inflammation reactions in response to the composite were as mild as those of alumina ceramic alone in a subcutaneous implantation study. In bone implantation testing, the composite showed good bone tissue compatibility and connected directly to new bone. An in vitro cell attachment test was performed for osteoblasts, chondrocytes, fibroblasts, and smooth muscle cells, and CNT/alumina composite showed cell attachment similar to that of alumina ceramic.Discussion & conclusion: Owing to proven good biocompatibility and bone tissue compatibility, the application of CNT/alumina composites as biomaterials that contact bone, such as prostheses in arthroplasty and devices for bone repair, are expected.4

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“…The answer of the host to these bioceramics is the formation of a very fine fibrous tissue capsule of varying thickness, several micrometers or less, that surround implant materials. The fixation of implants in the body is made through a strong mechanical interlocking, by tissue ingrowth into undulating surfaces [11]. When high strength is required, the bond is made by perforations in the implants using threads, cements, etc.…”

Section: Bioinert Ceramicsmentioning

confidence: 99%

Crystalline Bioceramic Materials

Aza

2006

ChemInform

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A strong interest in the use of ceramics for biomedical engineering applications developed in the late 1960´s. Used initially as alternatives to metallic materials in order to increase the biocompatibility of implants, bioceramics have become a diverse class of biomaterials, presently including three basic types: relatively bioinert ceramics; bioactive or surface reactive bioceramics and bioresorbable ceramics. This review will only refer to bioceramics "sensus stricto", it is to say, those ceramic materials constituted for nonmetallic inorganic compounds, crystallines and consolidated by thermal treatments of powders to high temperatures. Leaving bioglasses, glass-ceramics and biocements apart, since, although all of them are obtained by thermal treatments to high temperatures, the first are amorphous, the second are obtained by desvitrification of a glass and in them vitreous phase normally prevails on the crystalline phases and the third are consolidated by means of a hydraulic or chemical reaction to room temperature. A review of the composition, physiochemical properties and biological behaviour of the principal types of crystalline bioceramics is given, based on the literature data and on the own experience of the authors. Key words: alumina, zirconia, zirconia-toughened alumina, graphite, hydroxyapatite, bioactive silicates, bioeutectic � , tricalcium phosphate Materiales biocerámicos cristalinosA finales de los años sesenta se despertó un gran interés por el uso de los materiales cerámicos para aplicaciones biomédicas. Inicialmente utilizados como una alternativa a los materiales metálicos, con el propósito de incrementar la biocompatibilidad de los implantes, las biocerámicas se han convertido en una clase diversa de biomateriales, incluyendo actualmente tres tipos: cerámicas cuasi inertes; cerámicas bioactivas o reactivas superficialmente y cerámicas reabsorbibles o biodegradables. En la presente revisión se hace referencia a las biocerámicas en sentido estricto, es decir, a aquellos materiales constitutitos por compuestos inorgánicos no metálicos, cristalinos y consolidados mediante tratamientos térmicos a altas temperaturas. Dejando aparte los biovidrios, los vitrocerámicos y los biocementos, puesto que, si bien todos ellos son obtenidos por tratamiento térmicos a altas temperaturas, los primeros son amorfos, los segundos son obtenidos por desvitrificación de un vidrio, prevaleciendo normalmente la fase vítrea sobre las fases cristalinas, y los terceros son consolidados mediante una reacción química o hidráulica a temperatura ambiente. Así pues, teniendo en cuenta la abundante bibliografía sobre el tema y la experiencia propia de los autores, se presenta una revisión de la composición, propiedades fisicoquímicas, aplicaciones y comportamiento biológico de los principales tipos de biocerámicas cristalinas.

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Re-evaluation of the biocompatibility of bioinert ceramics in vivo

Cited by 60 publications

References 13 publications

Effect of polymerization reaction inhibitor on mechanical properties and surface reactivity of bioactive bone cement

Effect of polymerization reaction inhibitor on mechanical properties and surface reactivity of bioactive bone cement

Biocompatibility and Bone Tissue Compatibility of Alumina Ceramics Reinforced with Carbon Nanotubes

Crystalline Bioceramic Materials

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