Re-evaluation of sexual dimorphism in human corpus callosum

Oka, Saeko; Miyamoto, Osamu; Janjua, Najma A.; Honjo-fujiwara, Naomi; Ohkawa, Motoomi; Nagao, Seigo; Kondo, Hiroko; Minami, Taeko; Toyoshima, Tetsuhiko; Itano, Toshifumi

doi:10.1097/00001756-199904060-00008

Cited by 25 publications

(27 citation statements)

References 8 publications

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“…There was a statistically significant difference in the midsaggital area between right handed and left handed [14] 661±9 663±7 Kertesz et al [16] 724* 716* Clarke et al [5] 540* 550* Pujol et al [19] 577±115 582±91 Hardan et al [15] 671±100** Mostofsky et al [25] 627±73** Oka et al [18] 657±80** Laissy et al [17] 636** Suganthy et al [7] 700±84* *Sd Not Presented **No Gender Specified subjects (p=0.048). Also, there was a statistically significant difference in r3 distance between those using their right hand and those using their left hand in cleaning the blackboard (p=0.041) (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Oka et al [17] have reported gender differences in four specific angles of the CC. We found the angle of genu as 74.06±19.98º in male, and 69.61±16.36º in female.…”

Section: Discussionmentioning

confidence: 99%

“…[12] There are many studies where CC and cerebral hemisphere widths and areas have been measured on MR images. [13][14][15][16][17][18][19] A longer CC in males has been reported in two studies. [7,20] However, most researchers have not identified sexual dimorphism in callosal length.…”

Section: Discussionmentioning

confidence: 99%

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Morphometric Assessment Of Corpus Callosum And Cerebral Hemispheres With Magnetic Resonance Imaging

Kocabıyık¹,

Kılıç²,

Baykal³

et al. 2009

TUTFD

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© Trakya Üniversitesi T p Fakültesi Dergisi. AVES Yay nc l k taraf ndan bas lm t r. Her hakk sakl d r. © Medical Journal of TrakyaObjective: In this study, our purpose was to assess the relationship between handedness, footedness and the morphological differences of certain intracranial structures on MR images. Material and Methods:63 healthy male and 52 healthy female individuals were included in the study. In each subject, 16 measurements of intracranial structures were taken on MR images. Area of corpus callosum, also left and right cerebral hemispheres, length of CC, width of genu (r1), truncus (r2), isthmus (r3) and splenium of CC (r4) and width of corresponding cerebral hemisphere were measured.Results: There was a statistically significant difference in R3 (width of the corresponding cerebral hemisphere to r3) distance between those using their right feet and those using their left feet. Angle of genu in right-handed people was greater in males than in females. Angle of genu in cases using the left foot was greater in females than in males for standing on one leg. Conclusion:Morphometric assessment of CC with MR imaging related to handedness and footedness may be useful in demonstrating the relationship between callosal morphology, gender differences and extremity preference in neuroscience.

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Section: Resultsmentioning

confidence: 99%

“…Oka et al [17] have reported gender differences in four specific angles of the CC. We found the angle of genu as 74.06±19.98º in male, and 69.61±16.36º in female.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Morphometric Assessment Of Corpus Callosum And Cerebral Hemispheres With Magnetic Resonance Imaging

Kocabıyık¹,

Kılıç²,

Baykal³

et al. 2009

TUTFD

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“…There is not much reason to assume that the CC functions in a predominantly inhibitory fashion in males and a predominantly excitatory fashion in females. While some researchers have claimed that the female CC, if scaled relative to whole brain size, is larger and thus facilitates transfer of information between the hemispheres (Oka et al, 1999; Mitchell et al, 2003), others have not found a difference (Bishop and Wahlsten, 1997; Luders et al, 2006; Zarei et al, 2006). Thus, there is little reason to speculate on the possibility of males and females differing with regard to the relation of tinnitus to callosal structure and function.…”

Section: Discussionmentioning

confidence: 99%

Structural changes of the corpus callosum in tinnitus

Diesch

Schummer

Krämer

et al. 2012

Front. Syst. Neurosci.

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Objectives: In tinnitus, several brain regions seem to be structurally altered, including the medial partition of Heschl's gyrus (mHG), the site of the primary auditory cortex. The mHG is smaller in tinnitus patients than in healthy controls. The corpus callosum (CC) is the main interhemispheric commissure of the brain connecting the auditory areas of the left and the right hemisphere. Here, we investigate whether tinnitus status is associated with CC volume. Methods: The midsagittal cross-sectional area of the CC was examined in tinnitus patients and healthy controls in which an examination of the mHG had been carried out earlier. The CC was extracted and segmented into subregions which were defined according to the most common CC morphometry schemes introduced by Witelson (1989) and Hofer and Frahm (2006). Results: For both CC segmentation schemes, the CC posterior midbody was smaller in male patients than in male healthy controls and the isthmus, the anterior midbody, and the genou were larger in female patients than in female controls. With CC size normalized relative to mHG volume, the normalized CC splenium was larger in male patients than male controls and the normalized CC splenium, the isthmus and the genou were larger in female patients than female controls. Normalized CC segment size expresses callosal interconnectivity relative to auditory cortex volume. Conclusion: It may be argued that the predominant function of the CC is excitatory. The stronger callosal interconnectivity in tinnitus patients, compared to healthy controls, may facilitate the emergence and maintenance of a positive feedback loop between tinnitus generators located in the two hemispheres.

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“…Oka ve ark. [19] ise A ve C açılarının erkeklerde, B ve D açılarının ise kadınlarda geniş olduğunu belirtmişlerdir. Her iki çalışma da normal bireylerde yapıldığından bizim çalışmamızda cinsiyet karşılaştırması her iki grupta ayrı olarak yapılmıştır.…”

Section: Discussionunclassified

Chiari tip I malformasyonlu hastalarda korpus kallozumun morfometrik ölçümlerinin ve uzaysal oryantasyonunun değerlendirilmesi

Özkan¹,

İnci²,

Kızıldağ³

et al. 2012

CMJ

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ÖzetAmaç. Bu çalışmada, Chiari tip I malformasyonlu hastalarda korpus kallozumun morfometrik ölçümleri ve birtakım açı ölçümleri ile tespit edilen uzaysal oryentasyonunu normal populasyona göre değerlendirmek amaçlanmıştır. Yöntem. 3-65 yaş arası 28 Chiari tip I malformasyonlu hasta (14 kadın, 14 erkek) ve 41 sağlıklı olgunun, T1 veya T2 ağırlıklı orta sagital kesitli MR görüntülerinde korpus kallozumun uzunluk, yükseklik, tepe açısı ve uzaysal oryentasyonunu belirleyen 4 farklı açı (A, B, C, D açıları) ölçümü yapıldı. Ölçümler arası farkı belirlemek için istatistiksel olarak Independent-T testi kullanıldı. Korelasyon için Pearson korelasyon testi kullanıldı. Bulgular. Her iki grup karşılaştırıldığında oryentasyon açılarından B ve D açılarında anlamlı bir fark olduğu bulundu (p<0,05). A ve C açılarında, korpus kallozumun uzunluk, yükseklik ve santral açı ölçümlerinde ise istatistiksel olarak anlamlı bir fark bulunmadı (p>0,05).Yaş ile korpus kallozumun uzunluğu ve A açısı arasında pozitif korelasyon saptandı. (sırasıyla r: 0,446 p: 0,043, r: 0,494 p: 0,023). Cinsiyet ile morfometrik ölçümler ve açılar arasında anlamlı korelasyon saptanmadı. Sonuç. Korpus kallozumun uzaysal oryentasyonu Chiari tip I malformasyonlu olgularda normal populasyona göre farklılık göstermektedir. Bu sonuçlar, korpus kallozum çalışmalarında uzaysal oryentasyonun önemli bir faktör olabileceğini göstermekle birlikte daha geniş serilere ihtiyaç vardır.Anahtar sözcükler: Chiari tip I malformasyonu, korpus kallozum, morfometrik ölçümler, uzaysal oryantasyon AbstractAim. This study aimed to determine the morphometric measurement and spatial orientation of corpus callosum in patients with Chiari type I malformation. Methods. In 28 patients with Chiari type I malformation (14 women and 14 men) and 41 healthy individuals between the ages of 3-65, length and height of corpus callosum as well as the central angle and four angles (A, B, C, D angles) to understand the spatial characteristics of the callosum were measured in T1 or T2 weighted mid-sagittal MR images. Independent-T test was used to determine the statistical differences between the measurements. Moreover Pearson's coefficient of correlation was used to determine the correlations. Results. B and D angles of corpus callosum compared between the groups, had a significant difference (p<0.001). There was no statistical difference between the length and height of corpus callosum, as well as the central angle and other two angles (A and C) for spatial characteristics of the corpus callosum (p>0.05). There was a positive correlation between the age and length of corpus callosum and A angle (r: 0.446 p: 0.043, r: 0.494 p: 0.023, respectively). There was no correlation between gender and morphometric measurements. Conclusion. These results confirm that the spatial orientation of corpus callosum is different from the normal population in cases with Chiari Type I malformation. These results suggest that spatial orientation could be an important factor in studies of the corpus callosum, however, furt...

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Re-evaluation of sexual dimorphism in human corpus callosum

Cited by 25 publications

References 8 publications

Morphometric Assessment Of Corpus Callosum And Cerebral Hemispheres With Magnetic Resonance Imaging

Morphometric Assessment Of Corpus Callosum And Cerebral Hemispheres With Magnetic Resonance Imaging

Structural changes of the corpus callosum in tinnitus

Chiari tip I malformasyonlu hastalarda korpus kallozumun morfometrik ölçümlerinin ve uzaysal oryantasyonunun değerlendirilmesi

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