Re-evaluation of Developmental and Reproductive Toxicity of Ortho- Phenylphenol (OPP) and Sodium Ortho-Phenylphenate (SOPP)

Silva, Marilyn H.

doi:10.4172/2168-9296.1000123

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Sodium orthonitrophenolate (OPP) also used as fungicides after harvest treatment of citrus fruits and as disinfectants and preservatives [FAO]. Moreover widely used in agricultural and disinfectants in food utensil [5] reported that rats and mice treated with multi dose of OPP (0,25.10,25) reveal diminish fetal body weight, high incidences in delayed skeletal ossification and Percent postimplantation loss (12.2; 16.7; 19.2; 18.3) respectively. In addition, fetal mice treated with SOPP showed malformation (mice: cleft plate; rabbits: resorptions).…”

Section: Introductionmentioning

confidence: 99%

Effect of Long Term Administration of Atonik Compound in Female Rabbits on Hematological and Pathological Changes in Important Functional Body Organ

MJ¹,

Mohamed²,

Ghusoon³

2016

Anat Physiol

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Atonik is a synthetic bio stimulant consist of three phenolic compounds used as stimulant plant growth and development, farmers used atonik with high abuse for enhancements of fruit maturity so study done to detect the harmful effect of atonik in laboratory animal.Eight female rabbits of weighting (1.4-1.6) kg were obtained from animal house in college of Veterinary Medicine, animal housed two weeks before beginning study and all laboratory condition was taking into consideration. Animal randomly divided in to two main groups: Control group still without treatment at all period of study, Atonik group: each rabbits orally received 0.1 mg/kg /three time weekly (TIDW). Our result disturbance of hematological parameters specially WBCS, RBCS, HB and lymphocyte. Moreover histopathological section showing dilation of the central vein and filled with fluid and granuloma beside it, with vaculation of hypatocyte. Kidney reveals coagulative necrosis of renal tubules with distraction of glomerular tuft. Uterus of rabbits treated with 0.1 mg/kg bw atonik for 8 weeks showing necrosis of unrein glands. Ovary showed increase in the numbers of attratic follicles. Our result concluded that atonik has very harmful effect for reproduction, liver, and kidney.

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Section: Introductionmentioning

confidence: 99%

Effect of Long Term Administration of Atonik Compound in Female Rabbits on Hematological and Pathological Changes in Important Functional Body Organ

MJ¹,

Mohamed²,

Ghusoon³

2016

Anat Physiol

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Toxicity of Ortho-Phenylphenol (OPP) and Sodyum Ortho-Phenylphenate (SOPP)

Köse

Kocasari

2020

Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

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Ortho-phenylphenol (OPP) and sodium ortho-phenylphenate (SOPP) salt have been used world-wide for decades as fungicides and disinfectants. OPP is generally used as a hospital and household disinfectant, whereas SOPP is used as a fungicide in post-harvest treatment of citrus fruits and vegetables for the prevention of mold. Due to widespread use including many consumer applications, the fate of OPP in the mammalian organism has been the subject of numerous investigations over many years. The aim of this review is to give information about OPP and SOPP including metabolism, general toxicity, carcinogenicity and genotoxicity.

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Re-evaluation of Developmental and Reproductive Toxicity of Ortho- Phenylphenol (OPP) and Sodium Ortho-Phenylphenate (SOPP)

Cited by 2 publications

References 33 publications

Effect of Long Term Administration of Atonik Compound in Female Rabbits on Hematological and Pathological Changes in Important Functional Body Organ

Effect of Long Term Administration of Atonik Compound in Female Rabbits on Hematological and Pathological Changes in Important Functional Body Organ

Toxicity of Ortho-Phenylphenol (OPP) and Sodyum Ortho-Phenylphenate (SOPP)

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