Objective. The onset of a chronic health condition (CHC) can have a severe impact on an individual's life, affecting mental and physical health. This study's goal was to investigate psychological distress trajectories starting from one year before to four years after the onset of a physical CHC. The specific aims were to identify the number and shape of longitudinal psychological distress trajectories and to test health-related, psychological, social, and demographic factors predicting these trajectories.Methods. Two samples were drawn from the Swiss Household Panel dataset: a CHC sample (n = 361) and a 1 to 1 matched comparison sample of healthy individuals. Latent growth mixture modeling was used to identify psychological distress trajectories over six years. Factors predicting trajectories were then tested using multinomial logistic regression.Results. Four psychological distress trajectories were identified in the CHC sample: resilience (53.9%), chronic (22.2%), delayed (15.0%), and recovery (8.9%). In the comparison sample, two trajectories were identified: low psychological distress (90%) and elevated psychological distress (10%). Protective factors associated with resilient trajectory membership in the CHC sample are higher emotional stability, higher relationship satisfaction, and male gender.Conclusion. Individuals living with a CHC have an increased risk of vulnerability compared to a sample of healthy individuals. This advocates awareness of mental health issues following the onset of a CHC. In this regard, biopsychosocial factors (gender, emotional stability, and relationship satisfaction) offer prevention and intervention opportunities for more vulnerable individuals.