Re-entry-Mechanismus ventrikulärer Tachykardien bei inhomogener Repolarisation

Theisen, K.; Jahrmärker, H.

doi:10.1055/s-0028-1106349

Cited by 14 publications

(2 citation statements)

References 10 publications

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“…In our study, too, quinidine significantly prolonged the QT, interval. This QT, change is possibly related to reported cases of sudden death following the administration of quinidine (Theisen and Jahrmarker, 1975).…”

Section: Effect Of the Combination Quinidine/verapamil In Cases Of Atmentioning

confidence: 65%

Electrophysiological effects of quinidine alone and of the combination quinidine‐verapamil on av conduction in humans

Theisen

Scheininger

1983

Clinical Cardiology

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Summary:The influence of 320 mg quinidine administered intravenously (i.v.), as well as subsequent administration of 5 mg verapamil i.v. on atrioventricular conduction was studied in 8 patients during sinus rhythm and atrial stimulation with the aid of His bundle electrography. Among the electrophysiologic parameters of the atrium the sinus rate increased significantly after quinidine and again increased slightly after subsequent administration of verapamil. During sinus rhythm the PA interval was not influenced by either substance. Conversely, during atrial stimulation the STA interval increased significantly under the effect of quinidine, while verapamil had no further influence. As an indicator of conduction time in the AV node, the AH interval was decreased significantly by quinidine during sinus rhythm and atrial stimulation. This effect was significantly counteracted by the additional administration of verapamil. The HV interval as a measure of the His-Purkinje conduction was not significantly affected. The QRS duration was increased significantly by quinidine and was not further influenced by verapamil. The QT, and QT intervals increased significantly after administration .of quinidine and were again slightly, but significantly shortened by verapamil. Our investigations show that the combination of quinidine and verapamil, which has clinically been found to have a higher conversion rate than quinidine alone, is well justified from an electrophysiologic point of view and that undesirable quinidine-related effects, such as rapid AV conduction in cases of atrial fibrillation and flutter, can be avoided by the subsequent administration of verapamil.

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Section: Effect Of the Combination Quinidine/verapamil In Cases Of Atmentioning

confidence: 65%

Electrophysiological effects of quinidine alone and of the combination quinidine‐verapamil on av conduction in humans

Theisen

Scheininger

1983

Clinical Cardiology

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“…A long QT-interval due to cardiac disease, electrolyte disorders or cardioactive drugs is known as a predisponing factor for tachyarrhythmias emerging with re-entry mechanism. This is true especially if the repolarisation proceeds inhomogenously in cardiac tissue (Theisen & Jahrmarker 1975). The long QT-interval might also predispose for ventricular fibrillation due to Ron T-phenomenon, which has been shown to happen in quinidine therapy with high concentrations (Deglin ef a/.…”

Section: Discussionmentioning

confidence: 99%

Sotalol Intoxication, Two Patients with Concentration ‐ Effect Relationships

Neuvonen

Elonen

Tarssanen

1979

Acta Pharmacologica et Toxicologica

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Two adult patients ingested an overdose of 2.4 g and 8.0 g of sotalol hydrochloride, respectively, i.e. 7-25 times the mean daily dose. Certain signs as bradycardia and hypotension were similar to those described for other beta-blocking agents. In addition to these, however, both patients had severe cardiac tachyarrhythmias and a considerably prolonged QT-interval in their electrocardiogram. The decline of serum sotalol concentrations followed first-order kinetics with the elimination half-life of 13-1 5 hours. There was a good correlation between the serum sotalol concentration and the prolongation of the QT-interval. Sotalol differs from other beta-blocking agents in its effects on the action potential of the ventricular muscle and Purkinje fibers of the heart. This is likely to explain the different symptoms and findings of sotalol intoxication compared to those seen in connection with other beta-blocking agents.

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Orthorhythmic Stimulation and Endocardial Detection as a Diagnostic Tool

Theisen¹,

Jahrmärker²

1976

Cardiac Pacing

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Re-entry-Mechanismus ventrikulärer Tachykardien bei inhomogener Repolarisation

Cited by 14 publications

References 10 publications

Electrophysiological effects of quinidine alone and of the combination quinidine‐verapamil on av conduction in humans

Electrophysiological effects of quinidine alone and of the combination quinidine‐verapamil on av conduction in humans

Sotalol Intoxication, Two Patients with Concentration ‐ Effect Relationships

Orthorhythmic Stimulation and Endocardial Detection as a Diagnostic Tool

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