Re: Atopy and Risk of Non-Hodgkin lymphoma

Grulich, Andrew E.; Vajdic, Claire M.; Riminton, Sean; Hughes, Anne Maree; Kricker, Anne; Armstrong, Bruce K.

doi:10.1093/jnci/djm114

Cited by 10 publications

(14 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Allergy/atopy reactions are characterized by high levels of specific IgE responses to particular allergens, a readily measured immune marker. Some investigators have examined specific IgE levels as representing a more standardized approach to classifying persons with allergy/atopy than self‐reported history 17–21. Again, although the findings have not been entirely consistent, IgE levels appear to be generally higher in controls than NHL patients, consistent with the hypothesis that allergy/atopy is associated with a reduced risk of lymphoma 17–21.…”

mentioning

confidence: 99%

Immunoglobulin subclass levels in patients with non‐Hodgkin lymphoma

Biggar

Christiansen

Rostgaard

et al. 2009

Intl Journal of Cancer

View full text Add to dashboard Cite

Allergy/atopy has been suggested to protect against non-Hodgkin lymphoma (NHL) and specific IgE levels are decreased in patients with NHL. We speculated that all immunoglobulin subclass levels might be downregulated in NHL and examined levels of IgM, IgD, IgA, IgE, IgG and IgG 4 in 200 NHL patients and 200 age-and sexmatched controls. Patients with B-cell NHL of many types had consistently lower median immunoglobulin subclass levels than controls. In every subclass except IgD, about 10-15% of B-cell NHL patients had absolute levels below the 2.5 percentile of controls. Subclass levels correlated with each other and many patients had more than one significantly low level. Levels were lowest for IgG 4 and IgE. Patients with chronic lymphocytic leukemia/small lymphocytic lymphoma had especially low total IgE levels. In other B-cell NHL types, total IgE levels were decreased to a similar extent as other immunoglobulin subclasses. In conclusion, low IgE levels are only part of a more generalized loss of immunoglobulins of all subtypes in a wide variety of B-cell NHL types. Low immunoglobulin levels appear to be a consequence of B-cell NHL presence, and we speculate about molecular mechanisms that could reduce all immunoglobulin subclasses in B-cell NHL. ' 2008 Wiley-Liss, Inc.Key words: diffuse large B-cell NHL; follicular NHL; mantle cell NHL; Denmark; Sweden; stage; treatment; co-stimulation; CD80; CD86; B7-1; B7-2 Non-Hodgkin lymphoma (NHL) is a malignancy of the immune system but its relationship to immunity is complex. A prominent observation is that NHL incidence has been increasing steadily over the past several decades in the developed countries, 1 starting long before the abrupt increases of high grade lymphoma seen in association with the AIDS epidemic. 2 For the non-AIDS-related NHL types, this trend continued in the United States at least through 1998. 2 In Scandinavia, similar increases were observed into the early 1990s, but rates have stabilized in the past decade. 3 Some investigators proposed to explain this increase by a 'hygieneÕ hypothesis, which postulated that the impact of delaying a common infection might be responsible for increasing lymphoma risk, 4,5 but other explanations are plausible. It may be that, when naturally occurring mutations accumulate in undifferentiated, replicate-competent cells, lymphoma becomes more common. 6 A corollary to the hygiene hypothesis is that allergic/atopic conditions are becoming more common in the population. [7][8][9][10] Chronic immunologic stimulation by allergens may serve to differentiate the immune system. Many studies have attempted to correlate allergy/atopy history with risk of lymphoma, with conflicting results. 11-17 However, allergy/atopy represents a range of diverse conditions, ranging from hay fever and asthma to drug reactions. Furthermore, these conditions vary greatly in severity and hence in their recognition and reporting. These variations may lead to different immune impacts. Nevertheless, on balance, the evidence seems to favor lower l...

show abstract

mentioning

confidence: 99%

Immunoglobulin subclass levels in patients with non‐Hodgkin lymphoma

Biggar

Christiansen

Rostgaard

et al. 2009

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…32,33 IgG levels were not decreased in one study, 32 but in contrast, it was decreased in other studies, 33 while a study 34 showed no increase in IgG levels, and lower IgG levels in NHL patients was observed. 33,34 Levels of all immunoglobulin class were decreased in NHL patients. Another study which supports our results demonstrated that the most frequent hypoimmunoglobulinaemia is in class IgM (22%), followed by IgA (8%).…”

Section: Frequency Of M Bands Showed By Serum Protein Electrophoresismentioning

confidence: 74%

“…44 Elevated IgG has been reported by other author. 32,33 Normally plasma cells constitute 1% in the bone marrow but as the disease advances, tumor load in bone marrow increases up to 80 % depending on severity. These malignant plasma cells synthesize monoclonal antibody and release it to the circulation.…”

Section: Frequency Of M Bands Showed By Serum Protein Electrophoresismentioning

confidence: 99%

Serum immunoglobulin levels in patients with lymphoproliferative diseases in Erbil, Kurdistan region, Iraq

Maulood¹,

Alnaqshabandi

2017

Zanco J Med Sci

View full text Add to dashboard Cite

“…The inconsistency between cohort studies and case–control studies might be partially due to the reliance on self-report of allergic conditions, which is prone to recall bias and less objective 12. Moreover, patients with NHL might be associated with a reduced immunoglobulin reactivity; thus, these NHL cases might have a reduced immune response and allergic responses 4,50. The negative association between allergic conditions and the risk of NHL might be explained by reverse causality.…”

Section: Discussionmentioning

confidence: 99%

Allergic conditions are not associated with the risk of non-Hodgkin’s lymphoma or Hodgkin’s lymphoma: a systematic review and meta-analysis

Yang

Liang

et al. 2017

OTT

View full text Add to dashboard Cite

We aimed to systematically evaluate the association between allergic conditions and the risk of Hodgkin’s lymphoma (HL) and non-HL (NHL). Systematic literature searches in PubMed and Embase were conducted up to October 2015 to identify eligible studies. Either a fixed-effects model or a random-effects model was adopted to estimate overall odds ratios (ORs) according to heterogeneity across studies. Subgroup and publication bias analyses were applied. A total of 24 case–control studies and 13 cohort studies (conducted from 1987 to 2015) were included in the analysis of the risk of NHL. History of any allergic condition was inversely associated with the risk of NHL in case–control studies (OR =0.83, 95% CI 0.76–0.91), while the reduction in the risk of NHL was not observed in cohort studies (OR =1.18, 95% CI 0.98–1.42). Significant association with the risk of NHL was found for asthma, hay fever, food allergy, allergic rhinitis, and hives. In the pooled analysis of the risk of HL, 12 studies (two were cohort studies) were included. The pooled OR was 0.96 (95% CI 0.84–1.09) for case–control studies and 1.46 (95% CI 0.63–3.38) for cohort studies. For specific allergic condition, we observed a reduced risk of HL in individuals with hay fever and food allergy. In conclusion, history of any allergic condition was not significantly associated with the risk of NHL or HL. Several specific allergic conditions, including asthma, hay fever, food allergy, and allergic rhinitis, might be associated with a reduced risk of NHL, while individuals with hay fever or food allergy may have a reduced risk of HL.

show abstract

Re: Atopy and Risk of Non-Hodgkin lymphoma

Cited by 10 publications

References 5 publications

Immunoglobulin subclass levels in patients with non‐Hodgkin lymphoma

Immunoglobulin subclass levels in patients with non‐Hodgkin lymphoma

Serum immunoglobulin levels in patients with lymphoproliferative diseases in Erbil, Kurdistan region, Iraq

Allergic conditions are not associated with the risk of non-Hodgkin’s lymphoma or Hodgkin’s lymphoma: a systematic review and meta-analysis

Contact Info

Product

Resources

About

Re: Atopy and Risk of Non-Hodgkin lymphoma

Cited by 10 publications

References 5 publications

Immunoglobulin subclass levels in patients with non‐Hodgkin lymphoma

Immunoglobulin subclass levels in patients with non‐Hodgkin lymphoma

Serum immunoglobulin levels in patients with lymphoproliferative diseases in Erbil, Kurdistan region, Iraq

Allergic conditions are not associated with the risk of non-Hodgkin&rsquo;s lymphoma or Hodgkin&rsquo;s lymphoma: a systematic review and meta-analysis

Contact Info

Product

Resources

About

Allergic conditions are not associated with the risk of non-Hodgkin’s lymphoma or Hodgkin’s lymphoma: a systematic review and meta-analysis