RDW in patients with systemic lupus erythematosus. Influence of anaemia and inflammatory markers

Vayá, Amparo; Alis, Rafael; Hernández, J J Cruz; Calvo, Javier Martínez; Micó, Luisa; Romagnoli, Marco; Ricarte, Jose M

doi:10.3233/ch-131738

Cited by 38 publications

(34 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…34,35 Studies in adults also showed that increased RDW and RPR are correlated with inflammation. [18][19][20][21]36 The increase in RDW is thought to occur as a result of inflammatory cytokines inhibiting erythrocyte maturation and accelerating the passage of younger and larger reticulocytes into the peripheral circulation. 37 Garofoli et al 22 demonstrated that RDW was significantly higher in preterm infants with PDA, bronchopulmonary dysplasia, and late neonatal sepsis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Useful Platelet Indices for the Diagnosis and Follow-Up of Patent Ductus Arteriosus

et al. 2019

View full text Add to dashboard Cite

Objective The aim of this study was to assess the utility of early postnatal platelet indices in the prediction of hemodynamically significant patent ductus arteriosus (hsPDA) and its response to pharmacological treatment in preterm infants. Study Design The medical records of 971 infants with gestational age < 30 weeks and birth weight < 1,500 g were analyzed retrospectively. Infants with hsPDA comprised the study group and those without hsPDA comprised the control group. Complete blood count results were recorded, and red cell distribution width-to-platelet ratio (RPR) and platelet mass were calculated. Results A total of 481 infants, 169 in the hsPDA group and 312 in the control group, were included. In terms of platelet indices, the hsPDA group showed significantly lower mean platelet volume (MPV) and platelet mass, whereas RPR was significantly higher (p < 0.05, respectively). Multiple logistic regression analysis showed that RDS (relative ratio [RR]: 2.39; 95% confidence interval [CI]: 1.45–3.93; p < 0.001), MPV < 7.85 (RR: 3.71; 95% CI: 2.29–6.01; p < 0.001), and RPR > 0.070 (RR: 5.33; 95% CI: 3.28–8.65; p < 0.001) were independent risk factors for hsPDA. Conclusion Low MPV and platelet mass and high RPR in the first hours of life are risk factors for hsPDA and hsPDA refractive to pharmacological treatment with ibuprofen in preterm infants.

show abstract

Section: Discussionmentioning

confidence: 99%

“…RDW reflects the heterogeneity in erythrocyte volume, 18 and RPR is a relatively new parameter that can be easily derived. 19 RDW and RPR were shown to be indicators of inflammatory status in adult studies.…”

mentioning

confidence: 99%

Useful Platelet Indices for the Diagnosis and Follow-Up of Patent Ductus Arteriosus

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown that RDW was associated with the increased severity of inflammatory bowel disease (IBD), SLE [9,10], RA [11], and psoriatic arthritis [12,13]. Another recent study has also concluded that RDW was increased in patients with SLE [14].…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of red blood cell distribution width in systemic lupus erythematosus patients

Mohamed

Azmy

Elfadl

2020

Egypt Rheumatol Rehabil

View full text Add to dashboard Cite

Background Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder with wide variety of clinical presentations. Recently, red blood cell distribution width (RDW) has been used as an inflammatory marker, similar to the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) where systemic inflammation has been linked to increased RDW. Many researches have assessed independently selective different hematological markers that may reflect disease activity. Our study aims to examine a number of hematological parameters that could reflect disease activity and to assess if there is a relationship between different hematological parameter (RDW, neutrophils and lymphocytes) to reflect SLE activity using Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Results The study comprised 60 SLE patients (52 females and 8 males) with a mean age of 34.53 years and mean disease duration was 4.085 years. The RDW values were significantly higher (p < 0.001) when comparing active patients (16.64 ± 4.7) versus inactive patients (13.16 ± 2.67) and controls (12.7 ± 1.13). Otherwise, insignificant differences were reported when comparing inactive SLE patients versus the control group (p = 0.242). There were no significant correlations (p > 0.05) between neutrophil count and lymphocyte count with C3, C4, SLEDAI score, 24 h urinary proteins, platelets count but significant only with hemoglobin level (p = 0.001). Conclusion Increased RDW is connected with active disease status of SLE patients. RDW could be used as a surrogate marker of the inflammation rather than neutrophil and lymphocyte count. It is a simple and easy testing included in CBC thus RDW could be used as a possible indicator to assess disease activity.

show abstract

“…High RDW has been associated with inflammatory diseases. Vayá et al 12 investigated the association of RDW with inflammatory markers in systemic lupus erythematosus (SLE). In SLE without anemia, RDW correlated directly with fibrinogen and CRP.…”

Section: Discussionmentioning

confidence: 99%

The relationship between red cell distribution width and homozygous M694V mutation in familial Mediterranean fever patients

Uslu

Aydın

Inal

et al. 2015

Annals of Saudi Medicine

View full text Add to dashboard Cite

BACKGROUND AND OBJECTIVEFamilial Mediterranean fever (FMF) is characterized by recurrent and self-limiting attacks with peritonitis, pleuritis, arthritis, and erysipelas-like erythema. We aimed to investigate the red cell distribution width (RDW) level as an inflammatory marker in FMF patients compared with normal subjects.DESIGN AND SETTINGSA retrospective study of FMF patients at the Department of Gastroenterology, Cumhuriyet University, between November 2011-February 2013.METHODSA total of 249 FMF patients and 131 age- and sex-matched control participants were included in the currrent study. RDW levels were also analyzed by standard methods. Each patient was given 2 mL of blood sample to obtain genomic DNA.RESULTSStatistically significant differences were observed in RDW values between the FMF patients and the control group. Also, RDW levels were higher in the FMF patients with the homozygous M94V mutation compared with those with other mutations. The receiver-operating characteristic curve analysis suggested that the optimum RDW cutoff point for the FMF patients was 13.95, with a sensitivity, specificity, negative predictive value, and positive predictive value of 70%, 64%, 68%, and 66%, respectively (area under the curve: 0.711, 95% confidence interval 0.627–0.795, P<.0001).CONCLUSIONWe suggest that RDW may show subclinical inflammation in FMF patients. RDW may be a promising marker in predicting the homozygous M694V mutation in FMF patients.

show abstract

RDW in patients with systemic lupus erythematosus. Influence of anaemia and inflammatory markers

Cited by 38 publications

References 29 publications

Useful Platelet Indices for the Diagnosis and Follow-Up of Patent Ductus Arteriosus

Useful Platelet Indices for the Diagnosis and Follow-Up of Patent Ductus Arteriosus

Clinical significance of red blood cell distribution width in systemic lupus erythematosus patients

The relationship between red cell distribution width and homozygous M694V mutation in familial Mediterranean fever patients

Contact Info

Product

Resources

About