RDM1 promotes critical processes in breast cancer tumorigenesis

Chen, Yajun; Sun, Zhengwang; Zhong, Tianying

doi:10.1111/jcmm.14425

Cited by 10 publications

(6 citation statements)

References 29 publications

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“…As cancer progresses, more mutations accumulate in the DNA repair proteins of the tumor (41). Previous studies have shown that RDM1 potentiates RAD52-RAD51 signaling via p53-mediated transcriptional suppression (20,21). P53 plays an important role in regulating cell growth and apoptosis by triggering cell growth arrest or apoptosis through the regulation of various downstream targets (42).…”

Section: Discussionmentioning

confidence: 99%

“…Although there are few reports on the developmental role of RDM1 in tumors, studies have highlighted that RDM1 is upregulated in papillary thyroid cancer, non-small cell lung cancer, ovarian cancer and breast cancer. Knockdown of RDM1 can reduce the proliferation of tumor cells, increase cell apoptosis, and induce cell cycle arrest (18)(19)(20)(21). However, the role of RDM1 in LIHC remains largely unexplored.…”

Section: Introductionmentioning

confidence: 99%

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Correlation analysis of RDM1 gene with immune infiltration and clinical prognosis of hepatocellular carcinoma

Qiu

Cao

et al. 2021

Bioscience Reports

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Purpose: Hepatocellular carcinoma (LIHC) is one of the most common primary malignant liver tumors worldwide. The RAD52 motif-containing protein 1 (RDM1) has been shown to play a role in mediating DNA damage repair and homologous recombination. This study was designed to determine the expression of RDM1 and its prognostic value as well as its relationship with immune infiltration in LIHC patients. Methods: Oncomine and Tumor Immunoassay Resource were used to assess the expression of RDM1. PrognoScan and Kaplan-Meier bioinformatics database were used to analyze the impact of clinical influencing factors on prognosis. Finally, the TIMER and GEPIA databases were used to detect the correlation between expression of RDM1 and expression of marker genes related to immune infiltration. Immunohistochemistry (IHC) method was used to detect the expression level of RDM1 in 90 cases of hepatocellular carcinoma and adjacent normal liver tissues. Results: RDM1 expression was upregulated in most cancers. The expression of RDM1 was remarkably higher than that of the corresponding normal control genes in LIHC tissues. The increase in RDM1 mRNA expression was closely related to the decreases in overall survival and progression-free survival. Additionally, the increase in RDM1 mRNA expression was closely related to the infiltration levels of macrophages, CD8+ T cells and B cells and was positively correlated with a variety of immune markers in LIHC. Conclusion :The findings of this study demonstrate that RDM1 is a potentially valuable prognostic biomarker that can help determine the progression of cancer and is associated with immune cell infiltration in LIHC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlation analysis of RDM1 gene with immune infiltration and clinical prognosis of hepatocellular carcinoma

Qiu

Cao

et al. 2021

Bioscience Reports

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“…In those cancers, RDM1 was regarded as an oncogene that could transcriptionally attenuate p53 expression and increase RAD51 and RAD52 level. This potential regulation of p53/RAD52/RAD51 signaling by increased RDM1 may lead to dysfunctional DNA repair pathways and the suppression of cell cycle arrest and apoptosis, thus promoting the tumor growth ( Hermeking and Eick, 1994 ; Tong et al, 2018 ; Chen et al, 2019 ).…”

Section: Mechanisms Underlying the Carcinogenesis And Progression Of Hccmentioning

confidence: 99%

The Role of RNA Methyltransferase METTL3 in Hepatocellular Carcinoma: Results and Perspectives

Fan

Lin

Hao

et al. 2021

Front. Cell Dev. Biol.

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Hepatocellular carcinoma (HCC) is the 6th most prevalent cancer and the 4th leading cause of cancer-related death worldwide. Mechanisms explaining the carcinogenesis of HCC are not clear yet. In recent years, rapid development of N6-methyladenosine (m6A) modification provides a fresh approach to disclosing this mystery. As the most prevalent mRNA modification in eukaryotes, m6A modification is capable to post-transcriptionally affect RNA splicing, stability, and translation, thus participating in a variety of biological and pathological processes including cell proliferation, apoptosis, tumor invasion and metastasis. METTL3 has been recognized as a pivotal methyltransferase and essential to the performance of m6A modification. METTL3 can regulate RNA expression in a m6A-dependent manner and contribute to the carcinogenesis, tumor progression, and drug resistance of HCC. In the present review, we are going to make a clear summary of the known roles of METTL3 in HCC, and explicitly narrate the potential mechanisms for these roles.

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“…Recently, some new works have revealed that RDM1 has high expression level in papillary thyroid carcinoma and lung adenocarcinoma [11][12][13]. However, the expression of RDM1 in ovarian cancer remains to be explored.…”

Section: Rdm1 Is Up-regulated In Human Ovarian Carcinoma Tumoursmentioning

confidence: 99%

RDM1 plays an oncogenic role in human ovarian carcinoma cells

Cao

Sheng³

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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Ovarian cancer is one of the deadliest gynecological cancer, with a low overall 5-year survival rate. RDM1, RAD52 motif-containing protein 1, is sensitive to cisplatin, a common chemotherapy drug and it has an important role inDNA damage repair pathway. Until now, the effect of RDM1 in ovarian cancer is undiscovered. Here, clinical data shows that the tumour tissues of ovarian carcinoma patients with higher mRNA and protein expression of RDM1. Knockdown of RDM1 in ovarian carcinoma cells reduces cell proliferation and promotes apoptosis, consistent with the role RDM1 in the overexpression experiments. The research of xenograft mouse model shows stable knockdown of RDM1 significantly inhibits ovarian cancer tumour growth. These in vitro and in vivo results conclude that RDM1 plays an oncogenic role in human ovarian carcinoma. Interestingly, p53/RAD51/RAD52 signalling pathway can be regulated by RDM1, and the negative regulation of p53 by RDM1 may be one of major mechanisms for RDM1 to accomplish its oncogenic functions in ovarian carcinoma. Therefore, RDM1 may be a new target for the treatment of ovarian carcinoma.

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RDM1 promotes critical processes in breast cancer tumorigenesis

Cited by 10 publications

References 29 publications

Correlation analysis of RDM1 gene with immune infiltration and clinical prognosis of hepatocellular carcinoma

Correlation analysis of RDM1 gene with immune infiltration and clinical prognosis of hepatocellular carcinoma

The Role of RNA Methyltransferase METTL3 in Hepatocellular Carcinoma: Results and Perspectives

RDM1 plays an oncogenic role in human ovarian carcinoma cells

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