Understanding the relationship between
protein structure and function
can be challenging for students. Molecular visualization software
aids students in this problem by allowing manipulation of structures
from new and deeper perspectives. In this communication, an activity
using iMolview Lite, structure visualization software for portable
devices, is presented. By analyzing both human insulin and a designed
variant of this hormone with iMolview Lite, students explore different
protein structural elements and discuss how modifications on structure
affect the pharmacological action rate. After the class, students
expressed great satisfaction with the activity, highlighting it as
a friendly and an attractive way to explore the protein structure
and function relationship. In conclusion, iMolview Lite is a powerful
tool that offers meaningful learning and motivation; thus, it is useful
for students to comprehend the complex concept of molecular structure.
In addition, insulin and its designed variant represent an appealing
model of study. Overall, this activity allows students to gain a deeper
understanding of protein structure features and how to relate them
to function.