RCN3 Expression Indicates Prognosis in Colorectal Cancers

Ma, Shengzhe; Zhang, Xiaoming; Cheng, Xiangdong; Cao, Fuao; Xu, Mingsheng; Han, Xiangling; Sui, Jinke; Chang, Wenjun; Zhang, Wei

doi:10.32604/oncologie.2022.025411

Cited by 6 publications

(5 citation statements)

References 22 publications

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“…Both MR and CT enterography offer high-resolution imaging, enabling the visualization of small intestinal lesions from multiple perspectives and planes ( Li et al, 2023 ). MR enterography excels in providing clear images of the small intestinal lumen, external structures, and intestinal walls, whilst CT enterography allows the accurate display of morphological details and anatomical relationships between lesions in the small intestine and surrounding tissues ( Ma et al, 2022 ; Wang, Chen & Hu, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

A systematic review and meta-analysis of magnetic resonance and computed tomography enterography in the diagnosis of small intestinal tumors

Li,

Ye,

Zhou

et al. 2023

PeerJ

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Objective To explore the potential value of magnetic resonance (MR) and computed tomography (CT) enterography in the diagnosis of small intestinal tumor (SIT). Methods Articles reporting on the diagnosis of SIT by MR and CT enterography deposited in Chinese and foreign literature databases were identified and evaluated using the quality assessment of diagnostic accuracy studies (QUADAS). The diagnostic data extracted from the articles were adopted for meta-analysis using Meta-disc 1.40 software. Analysis was undertaken to compare the sensitivity, specificity, positive and negative likelihood ratios, and the diagnostic odds ratio (DOR) of MR and CT enterography in the diagnosis of SIT. The diagnostic values of the two imaging methods were analyzed by summary receiver operating characteristic (SROC) curves. The meta-analysis was registered at INPLASY (202380053). Results A total of eight articles, including 551 cases of SIT were included in this analysis. The pooled sensitivity and specificity of MR enterography were 0.92 (95% CI [0.89–0.95]) and 0.81 (95% CI [0.74–0.86]), respectively, whilst CT enterography had a sensitivity of 0.93 (95% CI [0.90–0.95]) and a specificity of 0.83 (95% CI [0.76–0.88]). For MR enterography, the combined positive likelihood ratio was 4.90 (95% CI [3.50–6.70]), the combined negative likelihood ratio was 0.10 (95% CI [0.07–0.14]), and the area under the receiver operating characteristic curve (AUROC) was 0.940. For CT enterography, the corresponding values were 5.40 (95% CI [3.90–7.40]), 0.08 (95% CI [0.06–0.12]), and 0.950, respectively. When the pretest probability for MR was assumed to be 50%, the posterior probabilities for positive and negative results were calculated as 83% and 9%, respectively. For CT enterography with a pretest probability of 50%, the posterior probabilities of positive and negative results were 84% and 8%, respectively. Conclusion MR and CT enterography have high accuracy in the diagnosis of SIT and have a valuable role in the diagnosis and management of these tumors.

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Section: Discussionmentioning

confidence: 99%

A systematic review and meta-analysis of magnetic resonance and computed tomography enterography in the diagnosis of small intestinal tumors

Li,

Ye,

Zhou

et al. 2023

PeerJ

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“…Colorectal cancer (CRC) is the third most frequent malignant tumour of the digestive system with the second highest mortality rate. Recent decades have experienced an increase in the incidence of CRC 1–3 . At present, immunotherapeutic strategies represented by immune checkpoint inhibitors could provide therapeutic options for patients with advanced CRC, though the overall efficacy is not satisfactory 4–6 .…”

Section: Introductionmentioning

confidence: 99%

“…

Colorectal cancer (CRC) is the third most frequent malignant tumour of the digestive system with the second highest mortality rate.Recent decades have experienced an increase in the incidence of CRC. [1][2][3] At present, immunotherapeutic strategies represented by immune checkpoint inhibitors could provide therapeutic options for patients with advanced CRC, though the overall efficacy is not satisfactory. [4][5][6] Metastasis is a process during which cancer cells at the primary lesion spread to surrounding tissues and distant organs and distant metastasis is a major cause of cancer death.

…”

mentioning

confidence: 99%

Single‐cell analysis revealed a potential role of T‐cell exhaustion in colorectal cancer with liver metastasis

Ling,

Zhang,

Liu

et al. 2024

J Cellular Molecular Medi

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Liver metastasis (LM) is an important factor leading to colorectal cancer (CRC) mortality. However, the effect of T‐cell exhaustion on LM in CRC is unclear. Single‐cell sequencing data derived from the Gene Expression Omnibus database. Data were normalized using the Seurat package and subsequently clustered and annotated into different cell clusters. The differentiation trajectories of epithelial cells and T cells were characterized based on pseudo‐time analysis. Single‐sample gene set enrichment analysis (ssGSEA) was used to calculate enrichment scores for different cell clusters and to identify enriched biological pathways. Finally, cell communication analysis was performed. Nine cell subpopulations were identified from CRC samples with LM. The proportion of T cells increased in LM. T cells can be subdivided into NK/T cells, regulatory T cells (Treg) and exhausted T cells (Tex). In LM, cell adhesion and proliferation activity of Tex were promoted. Epithelial cells can be categorized into six subpopulations. The transformation of primary CRC into LM involved two evolutionary branches of Tex cells. Epithelial cells two were at the beginning of the trajectory in CRC but at the end of the trajectory in CRC with LM. The receptor ligands CEACAM5 and ADGRE5‐CD55 played critical roles in the interactions between Tex and Treg cell‐epithelial cell, which may promote the epithelial‐mesenchymal transition process in CRC. Tex cells are able to promote the process of LM in CRC, which in turn promotes tumour development. This provides a new perspective on the treatment and diagnosis of CRC.

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“…The standard treatment for CRC is surgery, chemotherapy and radiotherapy [ [6] , [7] , [8] ], but there is limited variation between the effectiveness of these treatments and long-term survival, particularly for patients with metastatic CRC, where approximately 70%–75% of patients survive more than one year and 30%–35% of patients survive more than three years, compared to less than five years after diagnosis [ 9 , 10 ]. The molecular landscape of CRC on histological and clinical information of each patients differs greatly [ [11] , [12] , [13] ]. Therapeutic decisions based on molecular subtypes might be a promising strategy for treating CRC, and development of new drugs in a way that targets CRC subtypes has the potential to transform drug discovery research [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Classification of molecular subtypes for colorectal cancer and development of a prognostic model based on necroptosis-related genes

Li,

Lu,

et al. 2024

Heliyon

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RCN3 Expression Indicates Prognosis in Colorectal Cancers

Cited by 6 publications

References 22 publications

A systematic review and meta-analysis of magnetic resonance and computed tomography enterography in the diagnosis of small intestinal tumors

A systematic review and meta-analysis of magnetic resonance and computed tomography enterography in the diagnosis of small intestinal tumors

Single‐cell analysis revealed a potential role of T‐cell exhaustion in colorectal cancer with liver metastasis

Classification of molecular subtypes for colorectal cancer and development of a prognostic model based on necroptosis-related genes

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