RCAS1 expression in mobile tongue squamous cell carcinoma: An immunohistochemical study

Abstract

SummaryBackgroundThe receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that has been considered to play a crucial role in tumor progression by enabling cancer cells to evade immune surveillance. The present study aimed to evaluate the clinical significance of RCAS1 expression in mobile tongue squamous cell carcinoma (SCC).Material/MethodsRCAS1 protein expression was assessed immunohistochemically on 49 mobile tongue SCC tissue samples obtained from an equal number of patients and was statistically analyzed with clinicopathological characteristics and overall and disease-free patients’ survival.ResultsEnhanced RCAS1 expression was significantly associated with reduced depth of invasion (p=0.0069), low mitotic index (p=0.0251) and no evidence of muscular invasion (p=0.0098). A borderline association between RCAS1 expression and stromal inflammatory reaction was also noted (p=0.0660). RCAS1 expression was not associated with overall and disease-free survival.ConclusionsOur data support evidence for possible implication of RCAS1 at the early stage of tumor progression in mobile tongue SCC, whereas the survival prediction using RCAS1 expression as a clinical marker seems uncertain for this type of malignancy.

Association of Low Tumor Endothelial Cell pY397–Focal Adhesion Kinase Expression With Survival in Patients With Neoadjuvant-Treated Locally Advanced Breast Cancer

“…9 Bulk tumor FAK expression has been correlated with breast cancer progression, but definitive results vary. 6,[10][11][12][13][14][15][16] Evidence suggests that endothelial cell (EC) FAK expression levels correlate with the molecular subtype of breast cancer, indicating that EC-FAK expression is potentially more clinically relevant than tumor cell (TC) FAK expression in breast cancer. 10 Deletion of FAK in K14-positive epidermal cells reduces skin cancer progression.…”

“…FAK activation results in FAK-tyrosine (Y)-397-phosphorylation . Bulk tumor FAK expression has been correlated with breast cancer progression, but definitive results vary . Evidence suggests that endothelial cell (EC) FAK expression levels correlate with the molecular subtype of breast cancer, indicating that EC-FAK expression is potentially more clinically relevant than tumor cell (TC) FAK expression in breast cancer …”

Apoptotic function of tumor-associated antigen RCAS1 in oral squamous cell carcinoma

“…Receptor-binding cancer antigen expressed on SiSo cell (RCAS1) is recognized by the monoclonal antibody 22-1-1, and was initially identified in uterine adenocarcinoma [ 1 , 2 ]. Its expression is reportedly correlated with clinico-pathological parameters in 15 human cancers, such as clinical stage, histological subtype, differentiation, tumor size, depth of invasion, lymphovascular space involvement, lymph node metastasis, and cytological results [ 3 - 20 ]. RCAS1 acts as a ligand for a putative receptor in cell lines of several human tissue types and peripheral lymphocytes, such as activated T, B, and NK cells.…”

Investigations on the clinical significance of FOXP3 protein expression in cervical oesophageal cancer and the number of FOXP3+ tumour-infiltrating lymphocytes

“…However, there have been few studies on squamous cell carcinoma, especially of the head and neck. 12 In the present study, immunohistochemical methods were used to observe FOXP3 expression levels in cancer cells and lymphocytes from cervical oesophageal cancer tissue samples. The relationship between FOXP3 expression and clinical and pathological features of cervical oesophageal cancer was analysed, to investigate the biological significance of FOXP3 expression in the immune resistance of tumour cells in this cancer.…”