RCAN1C is differentially expressed in T helper cell subsets

Peroxo Compounds of Vanadium(V) and Niobium(V) as Potent Inhibitors of Calcineurin Activity towards RII‐Phosphopeptide

“…Calcineurin (CN), also known as protein phosphatase 2B, has been established as a key calmodulin dependent enzyme which plays a critical role in mammalian signal transduction pathways necessary for T-cell activation, nervous system development and function, cardiac growth and cell death mechanism. [1][2][3][4] CN is a serine/threonine phosphatase with the ability to dephosphorylate a broad range of proteins. [1,4] With the fascinating discovery that CN is the target of the immunosuppressant drugs cyclosporine A (CsA) and FK506 (tactolimus), [4] it has been firmly established that CN inhibitors are indispensable for preventing organ transplant rejection and to treat dermato-logic and autoimmune disorders.…”

“…[1][2][3][4] CN is a serine/threonine phosphatase with the ability to dephosphorylate a broad range of proteins. [1,4] With the fascinating discovery that CN is the target of the immunosuppressant drugs cyclosporine A (CsA) and FK506 (tactolimus), [4] it has been firmly established that CN inhibitors are indispensable for preventing organ transplant rejection and to treat dermato-logic and autoimmune disorders. [4][5][6][7][8] Since these drugs often lead to severe adverse side effects, [4,5] there has been a continued search for more specific, safer and effective alternative CN inhibitors.…”

“…[1,4] With the fascinating discovery that CN is the target of the immunosuppressant drugs cyclosporine A (CsA) and FK506 (tactolimus), [4] it has been firmly established that CN inhibitors are indispensable for preventing organ transplant rejection and to treat dermato-logic and autoimmune disorders. [4][5][6][7][8] Since these drugs often lead to severe adverse side effects, [4,5] there has been a continued search for more specific, safer and effective alternative CN inhibitors. Calcineurin inhibitors are also receiving increasing importance as valuable tool for basic research, [1,4,5] as these compounds would help to identify and characterize different targets of CN, thereby contributing to the elucidation of CN dependent signalling processes.…”

Amines, Amides, and Thio- and Carboxamides of (–)-Cytisine as Nfat Transcription Factor Modulators

“…However, excessive activation of this TF causes the development of immunopathological reactions such as autoimmune processes, inflammation, transplant rejection, carcinogenesis, and metastasis. Thus, the search for new NFAT modulators is extremely critical [1][2][3].A sufficient number of NFAT inhibitors/activators of natural and synthetic origin have now been identified [4][5][6]. However, such studies of the quinolizidine alkaloid (-)-cytisine and its derivatives have not been conducted.…”

“…However, excessive activation of this TF causes the development of immunopathological reactions such as autoimmune processes, inflammation, transplant rejection, carcinogenesis, and metastasis. Thus, the search for new NFAT modulators is extremely critical [1][2][3].…”