RBP7 functions as a tumor suppressor in HR+ breast cancer by inhibiting the AKT/SREBP1 pathway and reducing fatty acid
Yue Yu,
Zhihua Xu,
Xue Huang
et al.
Abstract:Background
Increasing evidence proves that RBP7 plays a significant role in breast cancer (BC). The present study was aimed to investigate the role of RBP7.
Methods
Western Blotting and qRT-PCR were performed for evaluating the expression levels. CCK8, colony forming, xenograft mouse model, wound healing and transwell assays were conducted to examine cell ability of proliferation, invasion and migration.
Results
RBP7 was significantly decreased in HR + BC tissues and cells. RBP7 suppressed HR + BC cell prol… Show more
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