“…For example, a recent study reported alterations in six metastable epialleles (CpG sequences with high inter-individual variation presumably due to stochastic methylation in early development) in 84 infants conceived during the protein-energy- and methyl-donor limited Gambian rainy season, in comparison to infants born in the dry season(57). Strikingly, one of the six nutrition-dependent epilalleles in the Gambian cohort(57), RBM46, encoding a regulator of early blastocyst and trophoectoderm differentiation(58), completely matched one of the G1 DMRs in our study (Gambia DMR hg18 , chr4:155,922,422-155,922,489, Barbados DMR: hg18, chr4: 155,921,670-155,922,589). Furthermore, DNA methylomics on 24 infants exposed to the war-related 1944/45 Dutch hunger winter at the time of conception, in comparison to their unaffected siblings, identified 181 DMRs, many of which related to growth and metabolism(59).…”