RBM4-MEF2C network constitutes a feed-forward circuit that facilitates the differentiation of brown adipocytes

Lin, Ji-Ping

doi:10.1080/15476286.2015.1017213

Cited by 21 publications

(24 citation statements)

References 45 publications

(72 reference statements)

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“…However, in this study, ssc-miR-1 and ssc-miR-133a, with highly abundant expression, were up-regulated in the adipose tissue of the Laiwu pig. Moreover, previous studies suggest that ssc-miR-1 and ssc-miR-133a are related to adipocyte differentiation in humans and rats [41,42]. Therefore, ssc-miR-1 and ssc-miR-133a may increase lipometabolism in pigs.…”

Section: Discussionmentioning

confidence: 94%

“…Previous studies have shown that some differentially and abundantly expressed miRNAs (down-regulated miRNAs: ssc-let-7i, ssc-miR-21, ssc-miR-27b-3p and up-regulated miRNAs: ssc-miR-1, ssc-miR-133a-3p, ssc-miR-486) were responsible for regulating adipogenic differentiation [36][37][38][41][42][43]. ssc-miR-1 and ssc-miR133a were found extensively in skeletal muscle tissues while ssc-miR-21, ssc-miR-27b-3p, and the Let-7 family play important roles in adipomuscle and myocardial tissue.…”

Section: Discussionmentioning

confidence: 99%

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WITHDRAWN: An integrated analysis of microRNAs involved in fat deposition in different pig breeds

Zhang¹,

Huang²,

Guo³

et al. 2017

Oncotarget

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The domestic pig, an important species in the animal production industry, is also a model system for studying fat deposition and fat-associated diseases in humans. In order to investigate the genetic relationships of the miRNAs that may regulate fat deposition, we performed a genome-wide analysis of miRNAs derived from subcutaneous adipose tissue of Laiwu and Large White pig using RNA-seq. A total of 26,486,906 reads were obtained. Further analysis indicated that 39 known miRNAs and 56 novel miRNAs had significantly differential expression between the two breeds of pigs. Gene Ontology and KEGG pathway analysis revealed that the predicted targets of these differentially expressed miRNAs were involved in several fat-associated pathways, such as the PPAR, MAPK and Wnt signaling pathways. In addition, we found that three miRNAs, ssc-miR-133a-3p, ssc-miR-486 and ssc-miR-1, had an impact on the development of porcine subcutaneous fat through the PPAR signaling pathway. This study provides clues to understand the potential mechanisms of adipogenesis and fat deposition between two different pig breeds. Furthermore, these results may also contribute to the research involving human obesity.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: An integrated analysis of microRNAs involved in fat deposition in different pig breeds

Zhang¹,

Huang²,

Guo³

et al. 2017

Oncotarget

View full text Add to dashboard Cite

show abstract

“…The SPTB interacts with phospholipids in natural [63] and model membrane systems [64] and has a role in controlling the fluidity of the inner lipid leaflet of the cell membrane (reviewed in [65]). MEF2C is a transcription factor involved in skeletal muscle differentiation; however, it has been reported as a constituent of a mechanism that programs gene expression involved in development of brown adipocytes [68]. MEF2A and MEF2D isoforms exhibited in vivo differential expression in mammalian striated muscle and white adipose tissue of insulindeficient diabetic mice [69].…”

Section: Epigenome-wide Association Analysis Showed Dna Methylation Cmentioning

confidence: 99%

Genome-Wide Scan for Common Variants Associated With Intramuscular Fat and Moisture Content in Rainbow Trout

Ali

Al-Tobasei

Lourenço³

et al. 2020

Preprint

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Background Genetic improvement of fillet quality attributes is a priority of the aquaculture industry. Muscle composition impacts quality attributes such as flavor, appearance, texture, and juiciness. Fat and moisture make up about ~80% of the tissue weight. The genetic architecture underlying the fat and moisture content of the muscle is still to be fully explored in fish. A 50K gene transcribed SNP chip was used for genotyping 789 fish with available phenotypic data for fat and moisture content. Genotyped fish were obtained from two consecutive generations produced in the National Center for Cool and Cold Water Aquaculture (NCCCWA) growth-selective breeding program. Estimates of SNP effects from weighted single-step GBLUP (WssGBLUP) were used to perform genome-wide association (GWA) analysis to identify quantitative trait loci (QTL) associated with the studied traits. Results Using genomic sliding windows of 50 adjacent SNPs, 137 and 178 SNPs were identified as associated with fat and moisture content, respectively. Chromosomes 19 and 29 harbored the highest number of SNPs explaining at least 2% of the genetic variation in fat and moisture content. A total of 61 common SNPs on chromosomes 19 and 29 affected the aforementioned traits; this association suggests common mechanisms underlying intramuscular fat and moisture content. Additionally, based on single-marker GWA analyses, 8 and 24 SNPs were identified in association with fat and moisture content, respectively. Conclusion SNP-harboring genes were primarily involved in lipid metabolism, cytoskeleton remodeling, and protein turnover. This work provides putative SNP markers that could be prioritized and used for genomic selection in breeding programs.

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“…While cnidarians have no identified period orthologue, and CK1 acts at the protein level, homologues of both clock and pdp1 ( bzip1 and bzip3 ) are also present in the DEGs in this group along with lark . Lark / rbm4 has also been reported to regulate splicing of mef2 in mammals (Lin, ). No major phase shifts in clock gene transcription cycles were observed, although they were common in other groups of genes identified in the GSEA, including “cellular response to stress” (Figure ).…”

Section: Resultsmentioning

confidence: 99%

Seasonal temperature, the lunar cycle and diurnal rhythms interact in a combinatorial manner to modulate genomic responses to the environment in a reef‐building coral

et al. 2019

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Rhythms of various periodicities drive cyclical processes in organisms ranging from single cells to the largest mammals on earth, and on scales from cellular physiology to global migrations. The molecular mechanisms that generate circadian behaviours in model organisms have been well studied, but longer phase cycles and interactions between cycles with different periodicities remain poorly understood. Broadcast spawning corals are one of the best examples of an organism integrating inputs from multiple environmental parameters, including seasonal temperature, the lunar phase and hour of the day, to calibrate their annual reproductive event. We present a deep RNA‐sequencing experiment utilizing multiple analyses to differentiate transcriptomic responses modulated by the interactions between the three aforementioned environmental parameters. Acropora millepora was sampled over multiple 24‐hr periods throughout a full lunar month and at two seasonal temperatures. Temperature, lunar and diurnal cycles produce distinct transcriptomic responses, with interactions between all three variables identifying a core set of genes. These core genes include mef2, a developmental master regulator, and two heterogeneous nuclear ribonucleoproteins, one of which is known to post‐transcriptionally interact with mef2 and with biological clock‐regulating mRNAs. Interactions between diurnal and temperature differences impacted a range of core processes ranging from biological clocks to stress responses. Genes involved with developmental processes and transcriptional regulation were impacted by the lunar phase and seasonal temperature differences. Lastly, there was a diurnal and lunar phase interaction in which genes involved with RNA‐processing and translational regulation were differentially regulated. These data illustrate the extraordinary levels of transcriptional variation across time in a simple radial cnidarian in response to the environment under normal conditions.

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RBM4-MEF2C network constitutes a feed-forward circuit that facilitates the differentiation of brown adipocytes

Cited by 21 publications

References 45 publications

WITHDRAWN: An integrated analysis of microRNAs involved in fat deposition in different pig breeds

WITHDRAWN: An integrated analysis of microRNAs involved in fat deposition in different pig breeds

Genome-Wide Scan for Common Variants Associated With Intramuscular Fat and Moisture Content in Rainbow Trout

Seasonal temperature, the lunar cycle and diurnal rhythms interact in a combinatorial manner to modulate genomic responses to the environment in a reef‐building coral

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