2018
DOI: 10.1038/s41408-018-0114-3
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RBFOX2 and alternative splicing in B-cell lymphoma

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Cited by 13 publications
(12 citation statements)
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“…Of note, factors implicated in splicing have the highest predictive power for pausing. This is in line with many studies that show dual roles for individual proteins such as RBFOX2 (99101), SRSF2 (32), U2AF65 (79) or MAGOH (79) providing a direct causal link between the two processes. One important goal of our analysis was to identify novel potential pausing regulators.…”
Section: Discussionsupporting
confidence: 91%
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“…Of note, factors implicated in splicing have the highest predictive power for pausing. This is in line with many studies that show dual roles for individual proteins such as RBFOX2 (99101), SRSF2 (32), U2AF65 (79) or MAGOH (79) providing a direct causal link between the two processes. One important goal of our analysis was to identify novel potential pausing regulators.…”
Section: Discussionsupporting
confidence: 91%
“…These indicated that the release of paused Pol II requires the formation of functional spliceosomes and that a positive feedback from the splicing machinery to the transcription machinery exists. In this context, RBFOX2 acts as a well established regulator of alternative splicing (99101) with an integral role in transcriptional pausing (95). Likewise, RBM15 (102), RBM22 (103, 104), PRPF8 (105), KHSRP (106) and YBX3 (107) as pre-mRNA splicing factors or spliceosome components are likely to have a similar connection to pausing as is the case for RBFOX2 and splicing in general.…”
Section: Resultsmentioning
confidence: 99%
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“…As such, binding of ADAR to exon-intron junction blocks exon recognition by the spliceosome, while binding of ADAR to intra-intronic dsRNA may promote exon inclusion by enhancing intron definition. RNA editing and splicing have been extensively studied, and dysregulation of both processes and their machineries impose considerable impact on cancer development 16,[28][29][30][31][32][33][34][35][36][37][38] . However, there are very limited understanding of the role of their crosstalk in cancer.…”
Section: Discussionmentioning
confidence: 99%
“…In this study, we seek to investigate the crosstalk between RNA editing and splicing machineries in the context of cancer, as dysregulations of both machineries are implicated in cancer 14,16,[28][29][30][31][32][33][34][35][36][37][38] . Approximately a hundred high-confidence splicing events regulated by ADAR1 or/and 2 are identified through a comprehensive transcriptome-wide RNA-sequencing (RNA-Seq).…”
mentioning
confidence: 99%