2004
DOI: 10.1038/ng1318
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Rb regulates proliferation and rod photoreceptor development in the mouse retina

Abstract: In the mouse, the seven main classes of retinal cell types (rod, cone, bipolar, horizontal, amacrine, ganglion and Müller glial cells) are produced from multipotent progenitor cells over a 17-d interval starting at embryonic day (E) 11.5 and continuing through postnatal day (P) 9. The overall size of the retina and the proportion of each cell type contained therein is essential for proper visual processing; therefore, during retinal development, cell cycle exit and cell fate specification are coordinated to en… Show more

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Cited by 188 publications
(195 citation statements)
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“…Importantly, this hyperacetylation leads to a down-regulation of transcription of these genes. Together with previous studies, these results indicate that rods uniquely require chromatin condensation for the proper level of expression of a set of genes required for rod differentiation and function (Neophytou et al 2004;Zhang et al 2004). By a mechanism yet to be determined, expansion of the polyglutamine tract in ataxin-7, a component of GCN5 histone acetyltransferase complexes, enhances their recruitment to rod-specific genes and thus alters chromatin structure at these genes.…”
Section: Sca 7: a Role In Cell-specific Chromatin Structuresupporting
confidence: 68%
“…Importantly, this hyperacetylation leads to a down-regulation of transcription of these genes. Together with previous studies, these results indicate that rods uniquely require chromatin condensation for the proper level of expression of a set of genes required for rod differentiation and function (Neophytou et al 2004;Zhang et al 2004). By a mechanism yet to be determined, expansion of the polyglutamine tract in ataxin-7, a component of GCN5 histone acetyltransferase complexes, enhances their recruitment to rod-specific genes and thus alters chromatin structure at these genes.…”
Section: Sca 7: a Role In Cell-specific Chromatin Structuresupporting
confidence: 68%
“…A subset of the apoptotic responses resulted from defective placental function and the ensuing hypoxia (Wu et al, 2003), but the proliferation and differentiation defects were generally cell autonomous. Additional proliferation and differentiation defects have been observed postnatally in tissue-specific Rb knockouts in the pituitary, lung, cerebellum, retina, prostate, and skin (Vooijs et al, 1998;Marino et al, 2003;Chen et al, 2004;MacPherson et al, 2004;Maddison et al, 2004;Ruiz et al, 2004;Wikenheiser-Brokamp, 2004;Zhang et al, 2004a). p107 and p130 are needed to control proliferation and differentiation in a more limited spectrum of tissues, including cartilage, epidermis, and brain Ruiz et al, 2003;Vanderluit et al, 2004).…”
Section: Focal Deficits In Pocket Protein Redundancy In Development Amentioning
confidence: 99%
“…The overall size of the retina, and the proportion of each of these cell types contained therein is essential for proper visual processing. To ensure that the adult retina forms appropriately during development, RPCs transition through states of developmental competence by coordinating cell cycle exit and cell fate specification to generate an ordered array of uniquely fated cell populations (Dyer and Cepko 2001;Fujita 2003;Pearson and Doe 2004;Zhang et al 2004;Kageyama et al 2005). When these processes are disrupted, as observed in some cases of human microphthalmia and anophthalmia (Zigman and Paxhia 1988;Loosli et al 1998;Fantes et al 2003;Driver et al 2005;Fitzpatrick and van Heyningen 2005;Labadie et al 2005;O'Brien et al 2005;Ragge et al 2005a,b;Xu et al 2005), vision is severely compromised.…”
mentioning
confidence: 99%