Raynaud's Phenomenon and Thyroid Deficiency

Shagan, Bernard P.

doi:10.1001/archinte.1980.00330180106029

Cited by 25 publications

(10 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The diagnosis of thyroid dysfunction in SSc may have an important impact also on the clinical manifestations of SSc; in fact, Raynaud's phenomenon is more difficult to control in hypothyroid individuals (44,45), and pulmonary hypertension (46) can be seriously influenced by hemodynamic changes of hypothyroidism. Thyroid function and ultrasonography should be tested as a part of the clinical profiling of SSc patients.…”

Section: Discussionmentioning

confidence: 99%

Clinical and subclinical autoimmune thyroid disorders in systemic sclerosis

et al. 2007

View full text Add to dashboard Cite

Objective: Several studies have reported the association of systemic sclerosis (SSc) with thyroid autoimmune disorders, but most of them have neither an appropriate control group nor include a complete thyroid work-up. Design: The aim of our study was to evaluate the prevalence of thyroid disorders in a large number of patients with SSc using a complete clinical evaluation. Methods: Thyroid-stimulating hormone (TSH), free triiodothyronine, free thyroxine, antithyroglobulin and antithyroid-peroxidase (AbTPO) autoantibodies, thyroid ultrasonography and blood flow and fine needle aspiration were performed in 202 SSc patients versus 404 gender-and age-matched controls from the general population, with similar iodine intake, to evaluate the prevalence of clinical and subclinical thyroid disorders. Results: Odds ratio (OR) for female SSc versus controls was: for subclinical hypothyroidism, 3.2 (95% CI)Z1.8-5.7); for clinical hypothyroidism, 14.5 (95% CIZ2.3-90.9); for AbTPO positivity, 2.7 (95% CIZ1.8-4.1); for hypoechoic pattern, 3.2 (95% CIZ2.2-4.7); for thyroid autoimmunity, 3.7 (95% CIZ2.6-5.4); for thyroid volume !6 ml, 1.8 (95% CIZ1.2-2.7). OR for thyroid autoimmunity in male SSc versus controls was 10.8 (95% CIZ2.2-52.4). Mean values of TSH in female SSc, and of AbTPO in female and male SSc were higher (P!0.01) than in controls. We observed three cases of Graves' disease in female SSc versus zero in controls (PZ0.0140), and two cases of papillary thyroid cancer in SSc patients. Conclusions: Thyroid function, AbTPO and ultrasonography should be tested as part of the clinical profile in SSc patients. Females, subjects with positive AbTPO and hypoechoic and small thyroid should have thyroid function follow-up and appropriate treatment in due course.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical and subclinical autoimmune thyroid disorders in systemic sclerosis

et al. 2007

View full text Add to dashboard Cite

show abstract

“…The vast majority of such patients are PVD subjects. An association between Raynaud's phenomenon and hypothyroidism was also described [128]. The causal relationship is not yet clear.…”

Section: General Symptoms and Signs Of Pvdmentioning

confidence: 99%

The primary vascular dysregulation syndrome: implications for eye diseases

2013

View full text Add to dashboard Cite

Vascular dysregulation refers to the regulation of blood flow that is not adapted to the needs of the respective tissue. We distinguish primary vascular dysregulation (PVD, formerly called vasospastic syndrome) and secondary vascular dysregulation (SVD). Subjects with PVD tend to have cold extremities, low blood pressure, reduced feeling of thirst, altered drug sensitivity, increased pain sensitivity, prolonged sleep onset time, altered gene expression in the lymphocytes, signs of oxidative stress, slightly increased endothelin-1 plasma level, low body mass index and often diffuse and fluctuating visual field defects. Coldness, emotional or mechanical stress and starving can provoke symptoms. Virtually all organs, particularly the eye, can be involved. In subjects with PVD, retinal vessels are stiffer and more irregular, and both neurovascular coupling and autoregulation capacity are reduced while retinal venous pressure is often increased. Subjects with PVD have increased risk for normal-tension glaucoma, optic nerve compartment syndrome, central serous choroidopathy, Susac syndrome, retinal artery and vein occlusions and anterior ischaemic neuropathy without atherosclerosis. Further characteristics are their weaker blood–brain and blood-retinal barriers and the higher prevalence of optic disc haemorrhages and activated astrocytes. Subjects with PVD tend to suffer more often from tinnitus, muscle cramps, migraine with aura and silent myocardial ischaemic and are at greater risk for altitude sickness. While the main cause of vascular dysregulation is vascular endotheliopathy, dysfunction of the autonomic nervous system is also involved. In contrast, SVD occurs in the context of other diseases such as multiple sclerosis, retrobulbar neuritis, rheumatoid arthritis, fibromyalgia and giant cell arteritis. Taking into consideration the high prevalence of PVD in the population and potentially linked pathologies, in the current article, the authors provide recommendations on how to effectively promote the field in order to create innovative diagnostic tools to predict the pathology and develop more efficient treatment approaches tailored to the person.

show abstract

“…CР наиболее часто отмечается у больных с системными ревматическими заболеваниями, однако также бывает проявлением или предвестником некоторых аутоиммунных, гематологических, эндокринных, неопластических и иных заболеваний [12]. СР встречается у 6% больных гипотиреозом и может быть ключом к ранней диагностике заболевания [13][14][15][16].…”

unclassified

Rheumatic manifestations of hypothyroidism

Теплова¹,

Eremeeva²,

Байкова³

et al. 2017

RJTAO

View full text Add to dashboard Cite

The rheumatic manifestations of endocrine diseases are well-known. The endocrine system has a complex effect on the structure and function of musculoskeletal tissues. The symptoms of locomotor apparatus injuries often come to the forefront in the clinical picture of an endocrine disease. It is therefore important to put endocrine diseases, including hypothyroidism, arthropathy, myopathy, etc., in a range of differential diagnoses of musculoskeletal system lesions. It should be remembered that changes in the locomotor system are able to partially or completely regress when endocrine disorders are adequately and long compensated for. The paper describes a clinical case in which, despite an obvious diversity of the typical clinical presentations of hypothyroidism, the main complaint was pain in the joints and muscles. In this connection, the female patient was initially misdiagnosed. This could be avoided if there was alertness to endocrine arthropathies and myopathies.

show abstract

Raynaud's Phenomenon and Thyroid Deficiency

Cited by 25 publications

References 4 publications

Clinical and subclinical autoimmune thyroid disorders in systemic sclerosis

Clinical and subclinical autoimmune thyroid disorders in systemic sclerosis

The primary vascular dysregulation syndrome: implications for eye diseases

Rheumatic manifestations of hypothyroidism

Contact Info

Product

Resources

About