Raynaud-Phänomen und Sklerodermie

Haustein, U F

doi:10.1007/s001050050427

Cited by 10 publications

(7 citation statements)

References 37 publications

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“…Bei der Erstvorstellung in unserer Klinik befand sich der 16jährige Patient in kachektischem Ernährungszustand (21,7 kg, Größe 155 cm) und wirkte insgesamt körperlich retardiert. Ellenbogen-, Knie-und Hüftgelenke waren ebenso wie die Finger-und Zehengrundgelenke stark beugekontrahiert (Tabelle 1).…”

Section: Körperlicher Untersuchungsbefundunclassified

Schwerer Verlauf einer mutilierenden pansklerotischen zirkumskripten Sklerodermie im Kindesalter

et al. 1999

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Disabling pansclerotic morphea of childhood is the most severe variant of localized scleroderma. It is characterized by rapid progression of deep cutaneous fibrosis expanding over large areas of body surface. The prognosis in terms of normal life activity is poor and the disease may even take a fatal course. Presented is a case with extremely severe and rapidly progressive lesions resulting in cutaneous ulcerations joint contractures, and multilaing deformities of the extremities. Histopathological analysis revealed extensive intravascular calcinosis of the small vessels, which may be an important factor in the pathogenesis of this poorly understood disease. UVA1-phototherapy was performed and induced a softening of sclerosis and a distinct decrease of skin thickness. Based on these observations UVA1-phototherapy may be promising in the treatment of extensive sclerotic disease of this kind, and possibly other diseases accompanied by excessive sclerosis.

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Section: Körperlicher Untersuchungsbefundunclassified

Schwerer Verlauf einer mutilierenden pansklerotischen zirkumskripten Sklerodermie im Kindesalter

et al. 1999

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“…Bleomycin gilt heute neben Vinylchlorid, Kunstharzen, Lösungsmit-teln, Kokainabusus, Silikon (Adjuvanskrankheit), verunreinigtem Rapssamenöl (Toxic-oil-syndrome), Tryptophan (Eosinophilie-Myalgie-Syndrom) und diversen Medikamenten wie D-Penicillamin als eine der Substanzen, die Sklerodermie-artige Krankheitsbilder (Pseudosklerodermien) auslösen oder eine progressive systemische Sklerodermie (PSS) selbst induzieren können [12,13]. Die Gruppe der Pseudosklerodermien stellt eine heterogene Gruppe lokalisierter bzw.…”

Section: Bleomycin-induzierte Pssartige Pseudosklerodermieunclassified

“…Im Vergleich zu den häufig auftretenden Hy-| Der Hautarzt 9·98 [11,19]. Die Mehrzahl der Pseudosklerodermien unterscheidet sich jedoch von der "echten" Sklerodermie durch fehlende Organbeteiligung, Aufhalten oder gar Reversibilität des Krankheitsprozesses nach Unterbrechung der Exposition [5,15] und andersartige Laborbefunde wie fehlende Autoantikörper sowie Thrombozytopenien [5,12,13]. Darüberhinaus fehlt bei der exogen induzierten Pseudosklerodermie die geschlechtsspezifische Gewichtung (PSS: Frauen/Männer=10/1; Tabelle 1).…”

Section: Besprechungunclassified

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Bleomycin-induzierte PSS- artige Pseudosklerodermie

Behrens

Reuther

et al. 1998

Der Hautarzt

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Although the association between administration of the antitumor agent bleomycin and the development of cutaneous fibrosis is established, there are only a small number of cases of bleomycin-induced scleroderma described in the literature. We report the development of generalised scleroderma with wide spread hyperpigmentation in a 52-year-old male patient, who received a total dose of 360 mg bleomycin in combination with cisplatin and etoposid for therapy of a malignant testicular seminoma. The clinical cutaneous alterations as well as the histological findings were indistinguishable from those encountered in progressive systemic sclerosis (PSS). In contrast to PSS however, Raynaud's phenomenon, cutaneous calcinosis, teleangiectasia, arthritis and involvement of additional organs were all absent. PSS-typical auto-antibodies were negative. Even 18 months after discontinuation of the drug and treatment with UVA1 phototherapy (3-4 times per week with 20 J/cm2) as well as physiotherapy, the skin changes had still not resolved. Based on our case and a detailed review of the literature, we discuss characteristics of bleomycin-induced scleroderma including pathogenesis, treatment modalities and course.

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“…Ebenso tragen strukturelle und funktionelle Veränderungen der perivaskulären Nervenfasern zur Genese des Vasospasmus bei der Sklerodermie bei [5]. Ebenso tragen strukturelle und funktionelle Veränderungen der perivaskulären Nervenfasern zur Genese des Vasospasmus bei der Sklerodermie bei [5].…”

Section: Besprechungunclassified

Fingerkuppennekrosen nach Dihydroergotaminmedikation bei limitierter systemischer Sklerodermie

Hahne

Balda

1998

Der Hautarzt

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A 78 year old women developed acute fingertip necrosis just a few days after starting dihydroergotamine. The lesions healed in 3 weeks after the medication was stopped. The patient had suffered from Raynaud syndrome for 5 years and limited systemic sclerosis was diagnosed during the necrotic episode. Advanced age and microangiopathies are contraindications to the use of ergot-containing preparations.

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Raynaud-Phänomen und Sklerodermie

Cited by 10 publications

References 37 publications

Schwerer Verlauf einer mutilierenden pansklerotischen zirkumskripten Sklerodermie im Kindesalter

Schwerer Verlauf einer mutilierenden pansklerotischen zirkumskripten Sklerodermie im Kindesalter

Bleomycin-induzierte PSS- artige Pseudosklerodermie

Fingerkuppennekrosen nach Dihydroergotaminmedikation bei limitierter systemischer Sklerodermie

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