Rautenlippe Redux—toward a unified view of the precerebellar rhombic lip

Ray, Russell; Dymecki, Susan M.

doi:10.1016/j.ceb.2009.10.003

Cited by 50 publications

(70 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…H&E-stained sections displayed typical histology with intratumoral nodules (e), and Gomori silver staining confirmed internodular desmoplasia (f). Global gene expression profile from this tumor displayed constitutive Sonic hedgehog signaling (g) types of the cerebellum, the lower rhombic lip (LRL), divided into the auditory and precerebellar compartment, produces cells that form parts of the cochlear nucleus complex and the precerebellar system, respectively [5,14,17,26]. So far, two different progenitor cell populations within the rhombic lip have been identified as possible origins for MB.…”

Section: Discussionmentioning

confidence: 99%

Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem

et al. 2012

View full text Add to dashboard Cite

Medulloblastoma is a malignant brain tumor of childhood that comprises at least four molecularly distinct subgroups. We have previously described that cerebellar granule neuron precursors may give rise to the subgroup with a molecular fingerprint of Sonic hedgehog (Shh) signaling. Other recent data indicate that precursor cells within the dorsal brain stem may serve as cellular origins for Wnt-associated medulloblastomas. To see whether Shh-associated medulloblastomas are also able to develop in the dorsal brainstem, we analyzed two lines of transgenic mice with constitutive Shh signaling in hGFAP- and Math1-positive brainstem precursor populations, respectively. Our results show that in both of these lines, medulloblastomas arise from granule neuron precursors of the cochlear nuclei, a derivative of the auditory lower rhombic lip. This region is distinct from derivatives of precerebellar lower rhombic lip where medulloblastomas arise in mice with constitutive-active Wnt signaling. With respect to their histology and the expression of appropriate markers, Shh tumors from the murine cochlear nuclei perfectly resemble human Shh-associated medulloblastomas. Moreover, we find that in a series of 63 human desmoplastic medulloblastomas, 21 (33%) have a very close contact to the cochlear nuclei on MR imaging. In conclusion, we demonstrate that precursors of the murine rhombic lip, which either develop into cerebellar or into cochlear granule neurons, may give rise to Shh-associated medulloblastoma, and this has important implications for the cellular origin of human medulloblastomas.

show abstract

Section: Discussionmentioning

confidence: 99%

Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Importantly, wnt1 is expressed in a decreasing dorsoventral gradient in the LRL, likely extending ventrally beyond the ngn1 domain (Landsberg et al, 2005; Ray and Dymecki, 2009). Using Cre and Flp based fate mapping studies, Rodriguez and Dymecki (2000) and Landsberg et al (2005) showed that mossy fiber-type precerebellar nuclei (BP, RTN, LRN, ECN) derive from the strongly wnt1 and math1 expressing dorsal LRL domain, while the climbing fiber system (IO) derives from weakly wnt1 and strongly ngn1 expressing ventral LRL domain.…”

Section: Molecular Revolutionsmentioning

confidence: 99%

The long adventurous journey of rhombic lip cells in jawed vertebrates: a comparative developmental analysis

et al. 2011

View full text Add to dashboard Cite

This review summarizes vertebrate rhombic lip and early cerebellar development covering classic approaches up to modern developmental genetics which identifies the relevant differential gene expression domains and their progeny. Most of this information is derived from amniotes. However, progress in anamniotes, particularly in the zebrafish, has recently been made. The current picture suggests that rhombic lip and cerebellar development in jawed vertebrates (gnathostomes) share many characteristics. Regarding cerebellar development, these include a ptf1a expressing ventral cerebellar proliferation (VCP) giving rise to Purkinje cells and other inhibitory cerebellar cell types, and an atoh1 expressing upper rhombic lip giving rise to an external granular layer (EGL, i.e., excitatory granule cells) and an early ventral migration into the anterior rhombencephalon (cholinergic nuclei). As for the lower rhombic lip (LRL), gnathostome commonalities likely include the formation of precerebellar nuclei (mossy fiber origins) and partially primary auditory nuclei (likely convergently evolved) from the atoh1 expressing dorsal zone. The fate of the ptf1a expressing ventral LRL zone which gives rise to (excitatory cells of) the inferior olive (climbing fiber origin) and (inhibitory cells of ) cochlear nuclei in amniotes, has not been determined in anamniotes. Special for the zebrafish in comparison to amniotes is the predominant origin of anamniote excitatory deep cerebellar nuclei homologs (i.e., eurydendroid cells) from ptf1a expressing VCP cells, the sequential activity of various atoh1 paralogs and the incomplete coverage of the subpial cerebellar plate with proliferative EGL cells. Nevertheless, the conclusion that a rhombic lip and its major derivatives evolved with gnathostome vertebrates only and are thus not an ancestral craniate character complex is supported by the absence of a cerebellum (and likely absence of its afferent and efferent nuclei) in jawless fishes

show abstract

“…Eph receptor-ephrin signaling furthermore partakes in cell segregation and positioning, tissue segmentation, cell migration, axon guidance, topographic mapping and morphogenesis rhombic lip likely contributes to the LL, whereas the complete CNC as well as a subpopulation of excitatory (glutamatergic) neurons of the SOC are descended from the lower rhombic lip of r2 to r5 (Farago et al 2006;Nichols and Bruce 2006;Rose et al 2009). This area of the lower rhombic lip is therefore also termed the auditory lip, whereas the lower rhombic lip from r6 to r8 (possibly until r11) is called the precerebellar lip (Farago et al 2006;Ray and Dymecki 2009) (Fig. 2).…”

Section: Embryonic Origin Of the Auditory Hindbrainmentioning

confidence: 99%

The emerging framework of mammalian auditory hindbrain development

et al. 2015

View full text Add to dashboard Cite

A defining feature of the mammalian auditory system is the extensive processing of sound information in numerous ultrafast and temporally precise circuits in the hindbrain. By exploiting the experimental advantages of mouse genetics, recent years have witnessed an impressive advance in our understanding of developmental mechanisms involved in the formation and refinement of these circuits. Here, we will summarize the progress made in four major fields: the dissection of the rhombomeric origins of auditory hindbrain nuclei; the molecular repertoire involved in circuit formation such as Hox transcription factors and the Eph-ephrin signaling system; the timeline of functional circuit assembly; and the critical role of spontaneous activity for circuit refinement. In total, this information provides a solid framework for further exploration of the factors shaping auditory hindbrain circuits and their specializations. A comprehensive understanding of the developmental pathways and instructive factors will also offer important clues to the causes and consequences of hearing-loss related disorders, which represent the most common sensory impairment in humans.

show abstract

Rautenlippe Redux—toward a unified view of the precerebellar rhombic lip

Cited by 50 publications

References 42 publications

Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem

Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem

The long adventurous journey of rhombic lip cells in jawed vertebrates: a comparative developmental analysis

The emerging framework of mammalian auditory hindbrain development

Contact Info

Product

Resources

About