Raumfordernde Zystenbildung nach der Operation maligner Gliome*

Abstract

Incidence and follow-up of patients with space-occupying cystic lesions after surgery of malignant gliomas are demonstrated. Aetiological aspects and therapeutic possibilities are mentioned.

Occurrence and Therapy of Space-Occupying Cystic Lesions after Brain Tumor Surgery

“…In the largest available and comparable series of 28 patients with space-occupying cystic lesions after surgery of malignant gliomas, Braunsdorf et al [1] found characteristics which show parallels to our patients. 12 patients (43%) had a second operation for tumor resection before, 66% had completed radiation therapy and in 21 patients (75%) the ventricular system was opened during the preceding tumor resection.…”

“…The appearance of space-occupying cystic lesions following resection, radiation therapy and chemotherapy or radiation therapy alone after resection of brain tumors has been reported by several authors [1,2,7,9,10,11]. Available larger series date from the era before microneurosurgery was introduced and different treatment modalities of brain tumors, in comparison to nowadays, were applied, but still these series show parallels to our results.…”

“…Especially primary and metastatic brain tumors may be accompanied by cystic lesions which may become large enough to cause compression of surrounding brain resulting in signs and symptoms of either raised intracranial pressure or focal neurological deficits. Apart from these ªprimaryº cysts, representing a part of the untreated tumor, space-occupying cystic lesions may also develop in a variable time after resection with or without following radiation-/chemotherapy of particular intracranial tumors [1,2,7,9,10,11]. This rare late complication of these procedures is detected mainly after the patient deteriorates with focal neurological deficits or raised intracranial pressure, mimicking tumor recurrence.…”

“…This rare late complication of these procedures is detected mainly after the patient deteriorates with focal neurological deficits or raised intracranial pressure, mimicking tumor recurrence. The pathomechanism of the cyst formation remains unclear, but a causal relationship to preceding radiation therapy, chemotherapy, infectious or bleeding complications is presumed [1,7,10].…”

“…According to the variety of location, size and configuration among other characteristic factors of such cystic lesions, a wide spectrum of more or less invasive therapeutic options can be applied [1,2,7,8,10,11].…”