Ratlarda Deneysel Siklofosfamid Toksikasyonunda Silimarin ve Curcuminin Koruyucu ve Antigenotoksik Etkileri

Avcı, Hamdi; Sekkin, Selim; Boyacıoğlu, Murat; Akşit, Hasan; Tunca, Recai; Epikmen, Erkmen Tuğrul; Birincioğlu, S. Serap

doi:10.9775/kvfd.2016.15145

Cited by 4 publications

(5 citation statements)

References 35 publications

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“…While pleomorphic nuclei (indicated by the yellow arrow) and focal necrosis (indicated by the black arrow) are observed in the heart muscle of the rats administered CPx + 5 mg/kg kefir (Figure 8d), a focal hyalinization area (indicated by the gray arrow) is observed in the heart muscle of the rats administered CPx + 10 mg/kg kefir (Figure 8f). Also, studies have shown that in the cardiac tissue of experimental groups given CPx, there are changes in the staining properties of the cell cytoplasm, a darker color and shrinkage in the nuclei, bleeding between muscle cells, small inflammatory cell foci and the separation of muscle fibers [12,25]. The histological findings of the experimental study conducted by Motawi et al (2010) involving the administration of 200 mg/kg CPx showed that there were hemorrhagic foci in the myocardium, deterioration and hyalinization in the myocardial fibers [33].…”

Section: Discussionmentioning

confidence: 99%

“…Studies have also shown that CPx induction causes hepatoxicity by increasing ALT, AST, ALP and LDH levels [ 21 , 22 ]. In many other studies, it has been reported that CPx applications at various doses increase enzymes such as AST, ALT, ALP, CK and LDH and cause histopathological changes [ 23 , 24 , 25 ]. Some antioxidative agents are used to suppress the high-dose effects of antineoplastic drugs and reduce oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

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In Vitro Antitumor and Antioxidant Capacity as well as Ameliorative Effects of Fermented Kefir on Cyclophosphamide-Induced Toxicity on Cardiac and Hepatic Tissues in Rats

Cetik Yildiz,

Demir,

Cengiz

et al. 2024

Biomedicines

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Fermented prebiotic and probiotic products with kefir are very important to slow down and prevent the growth of tumors and to treat cancer by stimulating the immune response against tumor cells. Cyclophosphamide (CPx) is widely preferred in cancer treatment but its effectiveness in high doses is restricted because of its side effects. The aim of this study was to investigate the protective effects of kefir against CPx-induced heart and liver toxicity. In an experiment, 42 Wistar albino rats were divided into six treatment groups: the control (Group 1), the group receiving 150 mg/kg CPx (Group 2), the groups receiving 5 and 10 mg/kg kefir (Groups 3 and 4) and the groups receiving 5 and 10 mg/kg kefir + CPx (Group 5 and 6). Fermented kefirs obtained on different days by traditional methods were mixed and given by gavage for 12 days, while a single dose of CPx was administered intraperitoneally (i.p.) on the 12th day of the experiment. It was observed that alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), creatinine kinase-MB (CK-MB), ischemia modified albumin (IMA) and Troponin I values, which indicate oxidative stress, increased in the CPx-administered group, and this level approached that of the control in the CPx + kefir groups. Likewise, as a result of the kefir, the rats’ CPx-induced histopathological symptoms were reduced, and their heart and liver tissue were significantly improved. In conclusion, it was observed that kefir had a cytoprotective effect against CPx-induced oxidative stress, hepatotoxicity and cardiotoxicity, bringing their biochemical parameters closer to those of the control by suppressing oxidative stress and reducing tissue damage.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

In Vitro Antitumor and Antioxidant Capacity as well as Ameliorative Effects of Fermented Kefir on Cyclophosphamide-Induced Toxicity on Cardiac and Hepatic Tissues in Rats

Cetik Yildiz,

Demir,

Cengiz

et al. 2024

Biomedicines

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“…Ref. According to Singh (1988), as referenced by Avci et al (2016) and Collins (2004) as referenced by Avci et al (2016) No OECD…”

Section: Bacterial Reverse Mutation Studiesmentioning

confidence: 99%

“…signif. increase of DNA damageCurcumin does not induce DNA damage and reduced damage by CP Negative DNA fragmentation in liver and kidney cells (ELISA): not increased by curcuminAccording to Singh (1988), as referenced by Avci et al () and Collins (2004) as referenced by Avci et al ()No OECD Reliable with restrictions Only one dose testedHighest dose tested below OECD recommendationsHistorical data not provided Low Çelik et al., BM cells of Swiss albino rats (Wistar rats), 6–8 week oldFemales (9 groups of 6 rats) curcumin treated group; 3 PFOS treated groups, 3 PFOS + Curcumin treated groupsNegative and positive controlsAim of the study:modulation on effects induced by perfluorooctane sulfonate (PFOS)Curcumin (Sigma Aldrich, purity > 94%) Relevance: high Vehicle: salinePositive control: MMC (2 mg/kg i.p. )Curcumin 80 mg/kg bw by gavage for 30 days at 48 h intervals, sacrificed 30 h after last treatmentCo‐administered with PFOS (0.6, 1.25 and 2.5 mg/kg bw)100 comet images scored per treatment; visually by two scorers, intensity for 0 (undamaged) to 4 (high damage)C+: stat.…”

Section: Appendix a – Summary Of The Available In Vitro And In Vivo Gmentioning

confidence: 99%

Safety and efficacy of turmeric extract, turmeric oil, turmeric oleoresin and turmeric tincture from Curcuma longa L. rhizome when used as sensory additives in feed for all animal species

Additives¹,

Bampidis²,

Azimonti³

et al. 2020

EFS2

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Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of turmeric extract, turmeric oil, turmeric oleoresin and turmeric tincture from Curcuma longa L. rhizome when used as sensory additives in feed and in water for drinking for all animal species. The FEEDAP Panel concludes that the additives under consideration are safe at the maximum proposed use levels: (i) turmeric extract at 15 mg/kg complete feed (or in water for drinking at comparable exposure) for all animal species; (ii) turmeric essential oil at 80 mg/kg feed for veal calves (milk replacer) and 20 mg/kg complete feed (or 20 mg/L) for all other species; (iii) turmeric oleoresin at 30 mg/kg complete feed (or 30 mg/L) for chickens for fattening and laying hens and 5 mg/kg complete feed (or 5 mg/L) for pigs, veal calves, cattle for fattening and dairy cows, sheep, goats, horses, rabbits and fish; (iv) turmeric tincture at 0.8 mL/L water for drinking for poultry, 6 mL per head and day for horses and 0.05 mL tincture/kg complete feed for dogs. No concerns for consumers were identified following the use of the additives at the proposed use level in animal nutrition. Turmeric extract, turmeric oil, turmeric oleoresin and turmeric tincture should be considered as irritants to skin and eyes and the respiratory tract and as skin sensitisers. The use of the additives in feed is not expected to pose a risk for the environment. Since turmeric and its preparations are recognised to flavour food and their function in feed would be essentially the same as that in food, no further demonstration of efficacy is considered necessary.

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“…The use of this plant in liver disease and the gastrointestinal problem describes in ancient medical books [9] . In folk medicine, in many countries, S. marianum (L.) is used for the treatment of gallbladder and liver disorders (jaundice, cirrhosis, and hepatitis) [10] and protection against environmental and chemical liver poisoning [11] . Silymarin is widely used as a nutritional supplement or therapeutic agent in liver disease without serious side-effects in both animals and humans [12,13] .…”

Section: Introductionmentioning

confidence: 99%

Doğal Enfekte Koyunlarda Silymarinin Klorsulon ile Kombinasyonunun Fasciola hepatica’ya Karşı Hepatoprotektif Aktivitesi

Aflatouni¹,

Panahi²,

Mortazavi³

et al. 2019

Kafkas Univ Vet Fak Derg

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Fasciolosis is a parasitic infection with socioeconomic implications that causes essential health problems in animals throughout the world. The current study intended to evaluate the hepatoprotective activity of silymarin alone and in combination with clorsulon in sheep naturally infected with Fasciola hepatica. For this purpose, a total of 40 sheep (Sangsari breed) were divided into five groups as follows: 1) the healthy sheep without treatment (the negative control), 2) the infected sheep without treatment (the positive control), 3) the infected sheep treated with silymarin (280 mg orally from the day 1 to 14), 4) the infected sheep treated with clorsulon (7.5 mg/kg orally on the days 5, 10, and 15), and 5) the infected sheep treated with silymarin + clorsulon. The assessed serum parameters included total bilirubin, total protein, albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT). Additionally, histopathological changes in naturally F. hepatica-infected sheep and controls were investigated using light microscopy. Biochemical analysis showed significantly lower levels of AST, ALT, ALP, GGT, bilirubin, protein, and albumin in infected animals than in the healthy group (P<0.05). Silymarin plus clorsulon treatment showed a remarkable improvement in both biochemical and histopathological parameters (P<0.05). In conclusion, the results of the biochemical analysis were in line with the pathological findings showing that silymarin, in combination with clorsulon, was superior to each compound alone in terms of hepatoprotective activity.

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Ratlarda Deneysel Siklofosfamid Toksikasyonunda Silimarin ve Curcuminin Koruyucu ve Antigenotoksik Etkileri

Cited by 4 publications

References 35 publications

In Vitro Antitumor and Antioxidant Capacity as well as Ameliorative Effects of Fermented Kefir on Cyclophosphamide-Induced Toxicity on Cardiac and Hepatic Tissues in Rats

In Vitro Antitumor and Antioxidant Capacity as well as Ameliorative Effects of Fermented Kefir on Cyclophosphamide-Induced Toxicity on Cardiac and Hepatic Tissues in Rats

Safety and efficacy of turmeric extract, turmeric oil, turmeric oleoresin and turmeric tincture from Curcuma longa L. rhizome when used as sensory additives in feed for all animal species

Doğal Enfekte Koyunlarda Silymarinin Klorsulon ile Kombinasyonunun Fasciola hepatica’ya Karşı Hepatoprotektif Aktivitesi

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