Ratios derived from an array of standard haematological indices predict the oncological outcome in colon cancer

Abstract

This is the first study to apply recursive partitioning in determining the relationship between haematological ratios and OS in colon cancer. Haematological ratios were predictive of oncological outcome. What does this paper add to the literature? This study suggests an association between systemic inflammation and oncological outcome.

The role of the systemic inflammatory response in predicting outcomes in patients with operable cancer: Systematic review and meta-analysis

“…One study reported on the WLR. The study was conducted by East and coworkers 30 from the UK. In this multivariate survival analysis on patients with colon cancer, WLR ≥3.4 was shown to predict worse overall survival (HR: 4.10 95% CI 3.13–7.42 p = 0.03).…”

The Predictive Role of the Neutrophil/Lymphocyte Ratio in Survival with Multiple Myeloma: A Single Center Experience

“…The sedimentation rate, inflammatory markers, such as CRP , and various markers and scores derived from the proportions of the inflammatory cells are found to be related to the prognosis in various solid tumors in addition to the absolute number of inflammatory cells. The neutrophil/lymphocyte ratio (NLR) obtained by the absolute neutrophil count divided by the absolute lymphocyte count has also been suggested as a prognostic marker related to the systemic inflammatory response in solid malignancies . A meta‐analysis covering 100 studies reported that a high NLR is associated with an adverse OS in many solid tumors .…”

Baseline neutrophil–lymphocyte ratio and platelet–lymphocyte ratio in rectal cancer patients following neoadjuvant chemoradiotherapy

“…Since it is known that systemic inflammation has an impact on tumor progression, many inflammatory response indicators have been studied to predict tumor response and prognosis after anticancer treatment, such as the level of lymphocytes, neutrophils, monocytes, platelets, C-reactive protein, erythrocyte sedimentation rate, interleukin-6, and the Glasgow Prognostic Scale. 9–12 Recently, elevated levels of neutrophils and platelets, decreased levels of lymphocytes, and their combination, high neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR), have been suggested to be poor prognostic factors in colorectal cancer patients. 9,13–15…”