Rationally designed rapamycin-encapsulated ZIF-8 nanosystem for overcoming chemotherapy resistance

Xu, Mingxiang; Hu, Yi; Ding, Weiping; Li, Fenfen; Lin, Jun; Wu, Min; Wu, Jingjing; Wen, Longping; Qiu, Bensheng; Wei, Pengfei; Li, Ping

doi:10.1016/j.biomaterials.2020.120308

Cited by 89 publications

(59 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Through the literature search, it was determined that there is great heterogeneity in the experimental methods and conditions between studies reporting on zeolites/ZIFs as anticancer drug delivery systems. The most common anticancer drug loaded were doxorubicin (DOX) [ 21 , 22 , 25 , 32 , 37 , 38 , 40 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ], 5-fluorouracil (5-FU) [ 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ], curcumin [ 14 , 69 , 70 ], cisplatin [ 71 , 72 ], and miR-34a [ 73 , 74 ]. The articles also employed a variety of both ZIFs and natural/synthetic zeolites ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

“…The articles also employed a variety of both ZIFs and natural/synthetic zeolites ( Table 1 ). Of the 53 articles included in this study, 36 studies utilized ZIFs [ 22 , 25 , 30 , 32 , 37 , 38 , 40 , 42 , 43 , 44 , 47 , 48 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 64 , 66 , 70 , 71 , 72 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 ], 9 studies utilized faujasite (FAU) [ 16 , 50 , 62 , 64 , 67 , 68 , 75 , 82 , 83 ], 5 studies utilized Zeolite A/Linde Type A (LTA) [ 14 , 49 , 63 , 68 , 82 ], and 3 studies utilized clinoptilolite [ 53 , 8...…”

Section: Discussionmentioning

confidence: 99%

“…DOX acts on the human body by intercalating itself between the base pairs of the DNA double helix [ 86 ]. This inhibits topoisomerase II activity, prevents DNA replication, and ultimately hinders protein synthesis [ 47 , 86 ]. Despite its prevalence, however, DOX lacks the ability to target certain areas of the body and possesses strong cardiotoxic effects [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review

Hao

Milašin²,

Eken

et al. 2021

Molecules

View full text Add to dashboard Cite

Zeolites and zeolitic imidazolate frameworks (ZIFs) are widely studied as drug carrying nanoplatforms to enhance the specificity and efficacy of traditional anticancer drugs. At present, there is no other systematic review that assesses the potency of zeolites/ZIFs as anticancer drug carriers. Due to the porous nature and inherent pH-sensitive properties of zeolites/ZIFs, the compounds can entrap and selectively release anticancer drugs into the acidic tumor microenvironment. Therefore, it is valuable to provide a comprehensive overview of available evidence on the topic to identify the benefits of the compound as well as potential gaps in knowledge. The purpose of this study was to evaluate the potential therapeutic applications of zeolites/ZIFs as drug delivery systems delivering doxorubicin (DOX), 5-fluorouracil (5-FU), curcumin, cisplatin, and miR-34a. Following PRISMA guidelines, an exhaustive search of PubMed, Scopus, Embase, and Web of Science was conducted. No language or time limitations were used up to 25th August 2021. Only full text articles were selected that pertained to the usage of zeolites/ZIFs in delivering anticancer drugs. Initially, 1279 studies were identified, of which 572 duplicate records were excluded. After screening for the title, abstract, and full texts, 53 articles remained and were included in the qualitative synthesis. An Inter-Rater Reliability (IRR) test, which included a percent user agreement and reliability percent, was conducted for the 53 articles. The included studies suggest that anticancer drug-incorporated zeolites/ZIFs can be used as alternative treatment options to enhance the efficacy of cancer treatment by mitigating the drawbacks of drugs under conventional treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review

Hao

Milašin²,

Eken

et al. 2021

Molecules

View full text Add to dashboard Cite

show abstract

“…[9] If the induced autophagy is pro-death, it can be utilized to directly kill cancer cells. [10][11][12] On the other hand, if the induced autophagy is pro-survival, inhibitors of autophagy can kill cancer cells or to sensitize cancer cells to other therapies, as we demonstrated for CuPd alloy nanoparticle recently. [13] Therefore, manipulating autophagic processes becomes a new method to improve the efficacy for nanomaterial-involved cancer treatment.The tree-like generation 5 poly(amidoamine) (PAMAM G5) dendrimer has been widely investigated as nanocarrier in cancer therapy due to its unique properties like nanometric size, easily modified surface, and the hydrophobic interior.…”

mentioning

confidence: 97%

mentioning

confidence: 97%

Photoresponsive PAMAM‐Assembled Nanocarrier Loaded with Autophagy Inhibitor for Synergistic Cancer Therapy

Jing

Wang

et al. 2021

Small

View full text Add to dashboard Cite

In nanomaterial-involved cancer therapy, elevated autophagy by nanoparticles oftentimes has a profound impact on cell fate, promoting either cell survival or cell death. [5] A variety of nanoparticles have been reported to induce autophagy, such as silver nanoparticles, [6] lanthanide oxide, [7] quantum dots, [8] and manganese oxide. [9] If the induced autophagy is pro-death, it can be utilized to directly kill cancer cells. [10][11][12] On the other hand, if the induced autophagy is pro-survival, inhibitors of autophagy can kill cancer cells or to sensitize cancer cells to other therapies, as we demonstrated for CuPd alloy nanoparticle recently. [13] Therefore, manipulating autophagic processes becomes a new method to improve the efficacy for nanomaterial-involved cancer treatment.The tree-like generation 5 poly(amidoamine) (PAMAM G5) dendrimer has been widely investigated as nanocarrier in cancer therapy due to its unique properties like nanometric size, easily modified surface, and the hydrophobic interior. [14,15] It is considered as a potentially suitable vehicle for various cargos, such as chemo drugs [16][17][18] and biomacromolecules. [19][20][21][22] Several activated-dendrimer structures, including PolyFect and SuperFect As one of the most promising drug-delivery carriers due to its small size, easy surface modifiability, and hydrophobic interior, cationic poly(amidoamine) (PAMAM) per se, demonstrated by previous reports and the authors' present study, indicate potential anticancer capability, however, which are restricted by autophagy elicitation. Besides, its side-toxicity profile, having also been extensively documented, limits its translation into the clinic. Herein, the authors design a photoresponsive PAMAM-assembled nanoparticle loaded with the autophagy inhibitor (chloroquine, CQ), which exhibits light responsiveness for precisely controlling drug release and superior dark biosafety. Upon light irradiation, the nanoparticle can dissociate into charged small PAMAM for a significant antitumor effect. Meanwhile, the released CQ can inhibit pro-survival autophagy induced by PAMAM to achieve an excellent synergistic anticancer efficacy in vitro and in vivo. The authors' study provided a vision of utilizing PAMAM as self-carried anticancer therapeutics in combination with an autophagy inhibitor and proposing a cancer therapy with high antitumor efficacy and low side effects to normal tissues.

show abstract

Ferroptosis‐Mediated Synergistic Therapy of Hypertrophic Scarring Based on Metal–Organic Framework Microneedle Patch

Zhao

Guo

Zhou

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Hypertrophic scarring, an abnormal fibroproliferative wound-healing disease, has brought tremendous burden for global healthcare systems. To date, no satisfactory treatment of hypertrophic scarring is available yet. Ferroptosis, an iron-dependent form of cell death, has attracted much attention recently for the therapy of diseases featuring iron addiction. Intriguingly, myofibroblasts derived from hypertrophic scarring are found to exhibit a high iron state which appears to be sensitive to trigger ferroptosis for scarring treatment. Accordingly, in this study, a pH responsive self-assembly nanoplatform is designed by encapsulating silver nanoclusters (AgNCs) and Chinese herbal medicine trigonelline (TRG) into zeolitic imidazolate framework-8 (ZIF-8) for synergistic ferroptosis therapy against hypertrophic scarring. The fabricated AgNC/TRG/ZIF-8 composites exhibit good biocompatibility and pH responsive-degradation inside myofibroblasts. The ZIF-8 precursors can increase the generation of lipid reactive oxygen species and deplete intracellular glutathione (GSH). Also, AgNCs have the capability to consume GSH, while TRG can inhibit the activity of glutathione peroxidase. Consequently, the synergistic ferroptosis anti-scarring therapy can be effectively achieved. Furthermore, AgNC/TRG/ZIF-8-loaded microneedle patches made of gelatin methacrylate show remarkable therapeutic effect against hypertrophic scarring on a rabbit ear model. This study suggests the great potential of ferroptosis-mediated strategy for treating fibrotic skin diseases in future clinical application.

show abstract

Rationally designed rapamycin-encapsulated ZIF-8 nanosystem for overcoming chemotherapy resistance

Cited by 89 publications

References 73 publications

Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review

Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review

Photoresponsive PAMAM‐Assembled Nanocarrier Loaded with Autophagy Inhibitor for Synergistic Cancer Therapy

Ferroptosis‐Mediated Synergistic Therapy of Hypertrophic Scarring Based on Metal–Organic Framework Microneedle Patch

Contact Info

Product

Resources

About