Rationally Designed Polymer Conjugate for Tumor-Specific Amplification of Oxidative Stress and Boosting Antitumor Immunity

Ma, Sheng; Song, Wantong; Xu, Yuxing; Si, Xinghui; Lv, Shixian; Zhang, Yu; Tang, Zhaohui; Chen, Xuesi

doi:10.1021/acs.nanolett.9b05265

Cited by 140 publications

(111 citation statements)

References 47 publications

Supporting

Mentioning

110

Contrasting

Unclassified

Order By: Relevance

“…Therefore, it is highly desirable to improve the immune response rate and selectively destroy primary solid tumors and metastatic lesions. In recent years, immunotherapy combined with nanotechnology, defined as nanoimmunotherapy, has shown promising performance for cancer therapy [ [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] ]. Among these therapeutics, metal-organic frameworks (MOFs), as a crystal material, has been widely studied in biomedical field [ [31] , [32] , [33] , [34] , [35] , [36] , [37] ].…”

Section: Introductionsmentioning

confidence: 99%

Reversing cold tumors to hot: An immunoadjuvant-functionalized metal-organic framework for multimodal imaging-guided synergistic photo-immunotherapy

Fan

Liu

Xue

et al. 2021

Bioactive Materials

113

View full text Add to dashboard Cite

Immunotherapy assays using immunoadjuvants and tumor antigens could greatly increase the survival rates of patients with malignant tumors. As effective carriers, metal-organic frameworks (MOFs) have been widely utilized in cancer therapy due to their remarkable histocompatibility and low toxicity. Herein, we constructed a multimodal imaging-guided synergistic cancer photoimmunotherapy by employing a specific MOF (MIL101-NH 2 ) as the core carrier; the MOF was dual-dressed with photoacoustic and fluorescent signal donors (indocyanine green, ICG) and immune adjuvants (cytosine-phosphate-guanine sequence, CpG) and named ICG-CpG@MOF. This nanocarrier could passively target the tumor site through the EPR effect and achieve multimodal imaging (fluorescence, photoacoustic, photothermal and magnetic resonance imaging) of the tumor. Synergistic cancer photoimmunotherapy was achieved via simultaneous photodynamic and photothermal methods with 808 nm laser irradiation. ICG-CpG@MOF achieved the GSH-controlled release of immunoadjuvant into the tumor microenvironment. Furthermore, the released tumor-associated antigen along with CpG could induce the transformation of tumor cells from cold to hot by activating the immune system, which significantly enhanced tumor cytotoxicity and achieved high cure rates with minimal side-effects. This strategy utilizing multimodal imaging and synergistic cancer photoimmunotherapy provides a promising approach for the diagnosis and treatment of cancer.

show abstract

Section: Introductionsmentioning

confidence: 99%

Reversing cold tumors to hot: An immunoadjuvant-functionalized metal-organic framework for multimodal imaging-guided synergistic photo-immunotherapy

Fan

Liu

Xue

et al. 2021

Bioactive Materials

113

View full text Add to dashboard Cite

show abstract

“…To better match the tumor microenvironment for precision responsiveness, there are two representative stimulus models for controlled drug release. The first one takes advantage of the biological differences of the endogenous stimulus, H 2 O 2 , [ 4 ] glutathione (GSH), [ 5 ] pH, [ 6 ] or enzymes, [ 7 ] between the tumor microenvironment and normal regions, which are frequently used as highly effective approaches to modulate the drug distribution. The other type of exogenous stimulus, such as X‐rays, [ 8 ] light, [ 9 ] and ultrasound, [ 10 ] is used to regulate the controllable drug release process.…”

Section: Methodsmentioning

confidence: 99%

Multi‐Responsive Bottlebrush‐Like Unimolecules Self‐Assembled Nano‐Riceball for Synergistic Sono‐Chemotherapy

et al. 2020

View full text Add to dashboard Cite

Improved drug loading content, bioavailability, and controlled release in targeted tissue have been major bottlenecks in the design of precision nanomedicine. Herein, a tumor‐specific and multiple‐stimuli responsive nano‐riceball is proposed and validated for enhanced sono‐chemotherapy. The nano‐riceball (NGR@DDP) possesses a well‐designed core‐shell structure, formed by an inner core assembly that contains ultrasound/H2O2 responsive bottlebrush‐like unimolecular dextran‐POEGMA9‐b‐PMTEMA22 (DOS) with co‐loaded doxorubicin and Purpurin 18. This inner core of NGR@DDP is further buried by a “striffen” of NGR (Asn‐Gly‐Arg)‐modified RBC‐membrane derived from CRISPR‐engineered mice. As a result, nano‐riceball NGR@DDP is featured with high drug stuffing content (30.3 wt%), low critical micelle concentration (5.93 µg mL−1), and intelligent exogenous ultrasound/endogenous H2O2 stimuli‐triggered precise drug release at tumor site. Under fluorescence/photoacoustic imaging guidance, combined sonodynamic therapy and chemotherapy exhibit excellent synergistic effect, and dramatically inhibit the growth of orthotopic HepG2 hepatocellular carcinoma with negligible side effects. This nano‐riceball strategy provides a facile way to achieve function hybridization for personalized nanomedicine.

show abstract

“…Intracellular oxidative stress could be selectively amplified by the introduction of ROS production agents or via the inhibition of intracellular antioxidant systems. Zhang et al, 2020) Furthermore, more functional polymer carriers can be engineered by introducing specific functional building blocks and by applying a design rationale favoring ROS-responsive polymers for drug delivery systems, which not only serve as carriers to deliver active drugs but also exert synergistic effects with the drug and greatly improve the therapeutic outcome of the drug (Ma S. et al, 2020).…”

Section: Conclusion and Future Challengesmentioning

confidence: 99%

Reactive Oxygen Species Responsive Polymers for Drug Delivery Systems

Gao

Xiong

2021

Front. Chem.

View full text Add to dashboard Cite

Reactive oxygen species (ROS) play an essential role in regulating various physiological functions of living organisms; however, as the concentration of ROS increases in the area of a lesion, this may undermine cellular homeostasis, leading to a series of diseases. Using cell-product species as triggers for targeted regulation of polymer structures and activity represents a promising approach for the treatment. ROS-responsive polymer carriers allow the targeted delivery of drugs, reduce toxicity and side effects on normal cells, and control the release of drugs, which are all advantages compared with traditional small-molecule chemotherapy agents. These formulations have attracted great interest due to their potential applications in biomedicine. In this review, recent progresses on ROS responsive polymer carriers are summarized, with a focus on the chemical mechanism of ROS-responsive polymers and the design of molecular structures for targeted drug delivery and controlled drug release. Meanwhile, we discuss the challenges and future prospects of its applications.

show abstract

Rationally Designed Polymer Conjugate for Tumor-Specific Amplification of Oxidative Stress and Boosting Antitumor Immunity

Cited by 140 publications

References 47 publications

Reversing cold tumors to hot: An immunoadjuvant-functionalized metal-organic framework for multimodal imaging-guided synergistic photo-immunotherapy

Reversing cold tumors to hot: An immunoadjuvant-functionalized metal-organic framework for multimodal imaging-guided synergistic photo-immunotherapy

Multi‐Responsive Bottlebrush‐Like Unimolecules Self‐Assembled Nano‐Riceball for Synergistic Sono‐Chemotherapy

Reactive Oxygen Species Responsive Polymers for Drug Delivery Systems

Contact Info

Product

Resources

About