Rationally designed molecules for resurgence of cyanide mitigated cytochrome c oxidase activity

Kaur, Harpreet; Singh, Palwinder

doi:10.1016/j.bioorg.2018.10.045

Cited by 7 publications

(7 citation statements)

References 50 publications

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“…Cyanide is a toxin that may be found in a variety of foods, as well as home and industrial items, some ready-made products included [ 25 ]. The combination of cyanide and cytochrome oxidase can paralyze cell respiration [ 26 ]. The signs and symptoms of cyanide poisoning may include abnormal breathing, that is, shortness of breath and dyspnea that progress to respiratory depression and apnea [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Identifying Obstructive Sleep Apnea Syndrome-Associated Genes and Pathways through Weighted Gene Coexpression Network Analysis

Zhao

et al. 2022

Computational and Mathematical Methods in Medicine

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Background. Obstructive sleep apnea syndrome (OSAS) is the most common type of sleep apnea disorder. The disease seriously affects the patient’s respiratory system. At present, the prognosis of the disease is poor and there is a lack of effective treatments. Therefore, it is urgent to explore its pathogenesis and treatment methods. Method. We downloaded a set of expression profile data from GSE75097 related to OSAS based on the Gene Expression Omnibus (GEO) database and selected the representative differentially expressed genes (DEGs) from the sample of the GSE75097 dataset. WGCNA was used to find genes related to OSAS and obtain coexpression modules. The Gene Ontology (GO) function and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway were used to analyze genes from key modules. Finally, Cytoscape software was used to construct a protein-protein interaction (PPI) network and analyze the hub genes. Result. We obtained a total of 7565 DEGs. Through WGCNA, we got four coexpression modules and the modules most related to OSAS were green-yellow, magenta, purple, and turquoise, and we screened out eight hub genes (DDX46, RNF115, COPA, FBXO4, PA2G4, NHP2L1, CDC20, and PCNA). GO and KEGG analyses indicated that the key modules were mainly enriched in tRNA modification, nucleobase metabolic process, DNA ligation, regulation of cellular component movement, basal transcription factors, Huntington disease, and vitamin digestion and absorption. Conclusion. These pathways and hub genes can facilitate understanding the molecular mechanism of OSAS and provide a meaningful reference for finding biological targets of OSAS treatment.

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Section: Discussionmentioning

confidence: 99%

Identifying Obstructive Sleep Apnea Syndrome-Associated Genes and Pathways through Weighted Gene Coexpression Network Analysis

Zhao

et al. 2022

Computational and Mathematical Methods in Medicine

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“…According to 1 H NMR stereoisomer ratio is 1.66:1. [ 36 ] Major isomer 1 H NMR (400.13 MHz, DMSO- d 6 , ppm): 3.89 (s, 6H, CH 3 ), 3.95 (s, 3H, CH 3 ), 6.86–6.95 (m, 2H, H ind ), 7.24 (t, J = 7.6 Hz, 1H, H ind ), 7.27 (s, 2H, H 2′ ,H 6′ ), 7.79–7.83 (m, 2H, H ind ,CH=), 8.13 (br.s, 1H, NH). Selected peaks of minor isomer 1 H NMR (400.13 MHz, DMSO- d 6 , ppm): 3.98 (s, 9H, CH 3 ), 6.88 (d, J = 7.7 Hz, 1H, H 7 ) 7.06 (t, J = 7.4 Hz, 1H, H ind ), 7.49 (s, 1H, CH=), 7.54 (d, J = 7.5 Hz, 1H, H 4 ), 8.02 (br.s, 1H, NH) ( E , Z )-3-(3,5-Dimethoxy-4-hydroxybenzylidene)-5-benzoylamino-2-oxindole 26 From 0.100 g (0.4 mmol) of 5-benzoylamino-oxindole, 0.089 g (0.4 mmol) of 3,5-dimethoxy-4-hydroxybenzaldehyde and 30 µL (0.35 mmol) of piperidine with ethanol as solvent the black powder (0.133 g, 79%) was obtained as a mixture of two isomers.…”

Section: Methodsmentioning

confidence: 99%

3-Arylidene-2-oxindoles as Potent NRH:Quinone Oxidoreductase 2 Inhibitors

et al. 2023

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The enzyme NRH:quinone oxidoreductase 2 (NQO2) plays an important role in the pathogenesis of various diseases such as neurodegenerative disorders, malaria, glaucoma, COVID-19 and cancer. NQO2 expression is known to be increased in some cancer cell lines. Since 3-arylidene-2-oxindoles are widely used in the design of new anticancer drugs, such as kinase inhibitors, it was interesting to study whether such structures have additional activity towards NQO2. Herein, we report the synthesis and study of 3-arylidene-2-oxindoles as novel NRH:quinone oxidoreductase inhibitors. It was demonstrated that oxindoles with 6-membered aryls in the arylidene moiety were obtained predominantly as E-isomers while for some 5-membered aryls, the Z-isomers prevailed. The most active compounds inhibited NQO2 with an IC50 of 0.368 µM. The presence of a double bond in the oxindoles was crucial for NQO2 inhibition activity. There was no correlation between NQO2 inhibition activity of the synthesized compounds and their cytotoxic effect on the A549 cell line.

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“…Cyanide toxicity is known because it can inhibit the mitochondrial cytochrome C oxidase and suppress oxygen transport. 23,24 Consequently, the development of sensitive and selective probes for the sensing of this anion has been gaining considerable attention in recent years because of its essential role in a wide variety of biological, 25 environmental, 26 biochemical, 27 clinical, 28 synthetical due to design and preparation of the respective chemosensors and industrial applications. 21,22 Considering the above background and our continuing interest in obtaining new functional uorophores, 20,[29][30][31] we planned to develop the octupolar dye A2 by a synthesis implying the twelve new bonds formation in a one-pot manner (Scheme 2c).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Photophysical and anion sensing properties of a triphenylamine–dioxaborinine trimeric compound

et al. 2023

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Rationally designed molecules for resurgence of cyanide mitigated cytochrome c oxidase activity

Cited by 7 publications

References 50 publications

Identifying Obstructive Sleep Apnea Syndrome-Associated Genes and Pathways through Weighted Gene Coexpression Network Analysis

Identifying Obstructive Sleep Apnea Syndrome-Associated Genes and Pathways through Weighted Gene Coexpression Network Analysis

3-Arylidene-2-oxindoles as Potent NRH:Quinone Oxidoreductase 2 Inhibitors

Photophysical and anion sensing properties of a triphenylamine–dioxaborinine trimeric compound

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