The cooperative active defense guidance problem for a spacecraft with active defense is investigated in this paper. An engagement between a spacecraft, an active defense vehicle, and an interceptor is considered, where the target spacecraft with active defense will attempt to evade the interceptor. Prior knowledge uncertainty and observation noise are taken into account simultaneously, which are vital for traditional guidance strategies such as the differential-game-based guidance method. In this set, we propose an intelligent cooperative active defense (ICAAI) guidance strategy based on deep reinforcement learning. ICAAI effectively coordinates defender and target maneuvers to achieve successful evasion with less prior knowledge and observational noise. Furthermore, we introduce an efficient and stable convergence (ESC) training approach employing reward shaping and curriculum learning to tackle the sparse reward problem in ICAAI training. Numerical experiments are included to demonstrate ICAAI’s real-time performance, convergence, adaptiveness, and robustness through the learning process and Monte Carlo simulations. The learning process showcases improved convergence efficiency with ESC, while simulation results illustrate ICAAI’s enhanced robustness and adaptiveness compared to optimal guidance laws.