Rationale for using a C-arm fluoroscope to deliver a kilovoltage radiotherapy treatment to COVID-19 patients

Roa, D; Moyses, Harry; Leon, Stephanie; Li, Benjamin; Tajima, T.; Nečas, Aleš; Guzman, Carmen; Páucar, Oliver; Gonzáles, Alberto; Challco, Roger; Montoya, M.; Arqque, Zintia; Gonzales, Andres; Hernandez, Juan

doi:10.1016/j.meddos.2020.07.008

Cited by 4 publications

(2 citation statements)

References 4 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unlike the high energy applications of LWFA and beam-driven wakefield accelerators, these medical radiotherapy applications look at the non-relativistic regime of the laser (the normalized laser strength parameter a 0 ¡1). Some of the researchers in medical radiation oncologists called for a departure from the traditional radiation therapy of cancer and even COVID such as Brachy therapy, due to the safety, convenience, and more accurate targeting of radiation [26,27,28]. In low energy electron therapy (such as 10's keV ) in some of these therapies (including the surface skin tumor treatments) the electron acceleration is very local using non-relativistic laser intensity [26].…”

Section: Crystal Channeling Muon Linear Collider Design Principlesmentioning

confidence: 99%

Channeling Acceleration in Crystals and Nanostructures and Studies of Solid Plasmas: New Opportunities

Ariniello¹,

Corde²,

Davoine³

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Recently started E336 collaboration will study excitation of transverse and longitudinal wakefields by an ultra-dense FACET-II electron bunch in evacuated channels such as stacks of CNTs or micron-or submicron channel arrays in O(1 mm) long dielectric targets. PIC simulations indicate that even with the micron-scale FACET-II bunches that extend over many nano-or micro-tubes, the PWA effects will result in beam nanomodulation and an easily detectable expansion of the angular spread of the 10-GeV beam electrons, far exceeding that from just a multiple scattering process. Next phase of the E336 experiments will study formation of the beam nano-bunches in the solid plasma, observation of the betatron radiation, and, eventually, particle acceleration by ultra-strong longitudinal wakefields.Required also is an in-depth research on dynamics of beam-plasma instabilities in ultradense plasma, its development and suppression in structured media like CNTs and crystals, and its potential use as a pre-modulator or as an amplifier for easier detection of the imprint of the nanostructure on the beam in E336 experiment. The recent invention of the thin film compression technique opens the way to introduce the availability of the singlecycled laser pulse and thus the relativistic compressed X-ray laser pulse, which fits the need for X-ray-driven nanostructure PWA. Given the tremendous promise of the crystal/CNT channeling acceleration and the not-yet fully explored complexity of the beam, laser and plasma physics involved in corresponding phenomena at the nanometer scales, exploration of promising near-term applications, serious theoretical analysis, and advanced computer

show abstract

Section: Crystal Channeling Muon Linear Collider Design Principlesmentioning

confidence: 99%

Channeling Acceleration in Crystals and Nanostructures and Studies of Solid Plasmas: New Opportunities

Ariniello¹,

Corde²,

Davoine³

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the absence of an antiviral that can effectively treat SARS-CoV-2 infection, Kirkby et al proposed to use low doses (<100 cGy) of radiation to treat COVID-19 induced pneumonia in patients . A strong reaction followed this article, with several publications supporting the consideration of radiotherapy for applications in COVID-19 treatment based on the anti-inflammatory activity of low dose radiation. − In contrast, other groups argued that current scientific evidence does not justify any clinical trial of low dose radiotherapy for COVID-19 pneumonia, − since the reported clinical studies investigating the potency of radiotherapy against viral pneumonia (published between the 1930s and 1970s) were conducted following protocols that did not abide by today’s clinical standards …”

Section: Therapeutic Strategies Against Covid-19mentioning

confidence: 99%

Diagnostic, Prognostic, and Therapeutic Use of Radiopharmaceuticals in the Context of SARS-CoV-2

Pallares

Abergel

2021

ACS Pharmacol. Transl. Sci.

View full text Add to dashboard Cite

The coronavirus disease 2019 (COVID-19) outbreak has devastated the healthcare systems and economies of over 200 countries in just a few months. The etiological agent of COVID-19, SARS-CoV-2, is a highly contagious virus that can be transmitted by asymptomatic and symptomatic carriers alike. While in vitro testing techniques have allowed for population-wide screening, prognostic tools are required to assess the disease severity and therapeutic response, contributing to improve the patient clinical outcomes. Moreover, no specific antiviral against COVID-19 exists at the time of publication, severely limiting treatment against the infection. Hence, there is an urgent clinical need for innovative therapeutic strategies that may contribute to manage the COVID-19 outbreak and prevent future pandemics. Herein, we critically examine recent diagnostic, prognostic, and therapeutic advancements for COVID-19 in the field of radiopharmaceuticals. First, we summarize the gold standard techniques used to diagnose COVID-19, including in vitro assays and imaging techniques, and then discuss how radionuclide-based nuclear imaging provides complementary information for prognosis and treatment management of infected patients. Second, we introduce new emerging types of radiotherapies that employ radioimmunoconjugates, which have shown selective cytotoxic response in oncological studies, and critically analyze how these compounds could be used as therapeutic agents against SARS-CoV-2. Finally, this Perspective further discusses the emerging applications of radionuclides to study the behavior of pulmonary SARS-CoV-2 aerosol particles.

show abstract

Covid-19 and radiotherapy: a systematic review after 2 years of pandemic

Piras¹,

Venuti

D’Aviero³

et al. 2022

Clin Transl Imaging

View full text Add to dashboard Cite

Introduction Following the Covid-19 pandemic spread, changes in clinical practice were necessary to limit the pandemic diffusion. Also, oncological practice has undergone changes with radiotherapy (RT) treatments playing a key role. Although several experiences have been published, the aim of this review is to summarize the current evidence after 2 years of pandemic to provide useful conclusions for clinicians. Methods A Pubmed/MEDLINE and Embase systematic review was conducted. The search strategy was “Covid AND Radiotherapy” and only original articles in the English language were considered. Results A total of 2.733 papers were obtained using the mentioned search strategy. After the complete selection process, a total of 281 papers were considered eligible for the analysis of the results. Discussion RT has played a key role in Covid-19 pandemic as it has proved more resilient than surgery and chemotherapy. The impact of the accelerated use of hypofractionated RT and telemedicine will make these strategies central also in the post-pandemic period.

show abstract

Rationale for using a C-arm fluoroscope to deliver a kilovoltage radiotherapy treatment to COVID-19 patients

Cited by 4 publications

References 4 publications

Channeling Acceleration in Crystals and Nanostructures and Studies of Solid Plasmas: New Opportunities

Channeling Acceleration in Crystals and Nanostructures and Studies of Solid Plasmas: New Opportunities

Diagnostic, Prognostic, and Therapeutic Use of Radiopharmaceuticals in the Context of SARS-CoV-2

Covid-19 and radiotherapy: a systematic review after 2 years of pandemic

Contact Info

Product

Resources

About