Rationale for use and clinical responsiveness of hexafluoro-1,25-dihydroxyvitamin D₃for the treatment of plaque psoriasis: a pilot study

Abstract

Topical F6-1,25(OH)2D3 is a safe and effective once a day treatment for psoriasis.

Psoriasis and Other Skin Diseases

“…This resolved with continued therapy after 3e4 weeks. Hexafluoro-1,25-dihydroxyvitamin D 3 -treated plaques also developed very mild perilesional scales as observed with other vitamin D analogs [57].…”

“…A double-blind, right/left comparison, placebocontrolled evaluation demonstrated efficacy and safety of topical treatment with hexafluoro-1,25(OH) 2 D 3 (5 mg/g) in psoriasis patients [57]. Adverse events included mild irritation.…”

Állásfoglalás

“…Ennek magyarázata lehet, hogy az aktív Dvitamin gyorsítja a keratocyták differenciálódá sát és gátolja a proliferációjukat [47,48,49], ugyan akkor előnyösen hat a betegség kialakulásában szerepet játszó immunfolyamatokra is [50]. Napjainkban a be tegség egyik alapkezelése az ideális Dvitaminszint biztosítása mellett alkalmazott kalcitriol vagy a kevéssé hypercalcaemizáló Dvitaminanalógok (kalcipotriol, ta kalcitol, maxakalcitol) lokális használata [51,52,53,54,55,56,57].…”

Vitamin D and the Skin

“…Such compounds might also be applied successfully for psoriasis. Hexafluoro‐1,25(OH) 2 D 3 is one such compound which has shown potent and long‐lasting inhibition of keratinocyte growth in vitro; application of 50 μg/g ointment to 15 psoriatic patients resulted in moderate to excellent improvement in more than 90% (42, 43). Another approach employs derivatives which are more rapidly metabolized to reduce any systemic effect when applied topically (44).…”