Rationale for universal WBC reduction of blood components?

Pittman, David L.

doi:10.1046/j.1537-2995.2000.40030389.x

Cited by 8 publications

(4 citation statements)

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“…Prestorage WBC reduction of cellular blood components removes donor WBCs before they undergo apoptosis or necrosis and before they release breakdown products at 4°C or cytokines at room temperature. Furthermore, although adverse transfusion reactions have been associated with the use of WBC‐reduction filters, 5–7 the FDA recently concluded that, “aside from specific device (filter) failures, there are no clinically significant adverse effects associated with leukocyte reduction.” 4 In fact, the reported severe hypotensive reactions to WBC‐reduced blood components have been associated only with the transfusion of blood components filtered at the bedside 8 . These reactions are attrib uted to the generation of bradykinin and, possibly, other vasodilators, as donor plasma passes over the filter media 9,10 .…”

mentioning

confidence: 99%

Universal WBC reduction:the case for and against

2001

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Universal WBC reduction:the case for and against

2001

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“…Leucodepletion of blood components has had a chequered history, even though the process of prestorage leucodepletion is almost risk‐free (Blajchman, 1999). There is controversy about the appropriate application and cost of this technology (Dzik et al ., 2000; Pittman, 2000; Thurer et al ., 2000). The debate whether to adopt selective or universal leucodepletion predates the outbreak of variant Creutzfeldt–Jakob disease (vCJD).…”

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confidence: 99%

Limited efficacy of universal leucodepletion in reducing the incidence of febrile nonhaemolytic reactions in red cell transfusions

Ibojie

Greiss

Urbaniak

2002

Transfusion Medicine

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This article demonstrates a 62% reduction in the number of febrile nonhaemolytic transfusion reactions (FNHTRs) and 50% reduction in febrile reaction rate associated with red cell transfusions following graded introduction of universal leucodepletion. Though this is a statistically significant reduction (P = 0.009), it shows limited efficacy in abrogating this complication. We also found a reduction in the proportion of cases of FNHTRs with lymphocytotoxic antibodies over the period studied from 54% in 1998, 28% in 1999 to 23% in 2000. This corresponds to a relative increase in the number of febrile reactions without human leucocyte antigen (HLA) antibodies following full implementation of universal leucodepletion, as the total number of reported reactions actually fell considerably during the period. The increase in the number of cases without HLA antibodies was directly proportional to the increase in the number of leucodepleted units used.

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“…It has been suggested that the use of γ-irradiation will decreases transfusion-transmitted CMV infection by mounting an immune response via indirect prevention of T-lymphocyte proliferation (25, 26) and the use of γ-irradiated blood products in newborn infants has been strongly suggested (27). We found a CMV infection rate of 2/20 (10%) using relatively fresh nonirradiated-nonfiltered blood in comparison to the previously reported 1/19 (5%) (10) using irradiated-nonfiltered seropositive blood.…”

Section: Discussionmentioning

confidence: 99%

Transfusion-related Cytomegalovirus Infection Among Very Low Birth Weight Infants in an Endemic Area

et al. 2006

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This study investigated the incidence of acquired cytomegalovirus (CMV) infection in very low birth weight infants (VLBWI) given CMV seropositive blood, and sought to determine whether filtering and irradiation of blood products could help prevent CMV infection and the time required to clear passively-derived anti-CMV IgG among 80 VLBWI transfused with filtered-irradiated blood, 20 VLBWI transfused with nonfiltered-nonirradiated blood and 26 nontransfused VLBWI. CMV IgG and IgM values were obtained from all blood products prior to transfusions, and from VLBWI at birth until the infants became seronegative. Urine was obtained for CMV culture at birth and every 3-4 weeks until 12 weeks after the final transfusion. The incidence of CMV IgG seropositivity among the 126 infants at birth and the blood products given were 96% and 95%, respectively. The incidence of acquired CMV infection was 4/100 (4%) in the transfused group: 2/80 (2.5%) and 2/20 (10%) in the filtered-irradiated and nonfiltered-nonirradiated transfusion groups, respectively. Approximately 9-10 months elapsed to clear passively acquired CMV IgG. The irradiation and filtering of the blood products did not seem to decrease the transfusion-related CMV infection rate in Korea among VLBWI, however, further validation is recommended in a larger cohort of infants.

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Rationale for universal WBC reduction of blood components?

Cited by 8 publications

References 1 publication

Universal WBC reduction:the case for and against

Universal WBC reduction:the case for and against

Limited efficacy of universal leucodepletion in reducing the incidence of febrile nonhaemolytic reactions in red cell transfusions

Transfusion-related Cytomegalovirus Infection Among Very Low Birth Weight Infants in an Endemic Area

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