Rationale for Treatment of Common Cold and Flu with Multi-Ingredient Combination Products for Multi-Symptom Relief in Adults

Abstract

This up-to-date overview will look at the rationale for the recommendation of combination products for multi-symptom relief of common cold and flu. Common cold and flu are defined by their multi-symptom nature with data showing a variety of symptoms reported simultaneously each day over the first six days of illness. Multi-ingredient combination products for multi-symptom relief are formulated to safely, simply, and simultaneously treat multiple symptoms when used as directed. The rationale for the formulation combination products for common cold and flu is therefore practical, logical and reasonable. No evidence has been found that multi-symptom relief medicines are inherently less safe than single-active ingredient medicines. Multi-symptom relief combination products containing several active ingredients provide a safe, effective, cost-effective, and convenient way of treating the multiple symptoms of common cold and flu, when used as directed. This therapy requires some special information for the patient to be provided by the physician and the pharmacist.

Efficacy and Safety of a Combination of Paracetamol, Levocetirizine and Phenylephrine in the symptomatic treatment of Common Cold and Allergic Rhinitis in Children: Phase IV Clinical Study

“…Paracetamol, Phenylephrine and Levocetirizine are specified in the list provided for antihistamine-analgesicdecongestant. Eccles et al 11 , theorize the rationale for bringing together multiple drugs in treatment of common cold to provide relief from multiple symptoms. The treatment of common cold by bringing together various drugs to provide relief from multiple symptoms.…”

“…Eccles et al 11 , stated that multi-ingredient combination products for multi-symptom relief are formulated to simply, safely and simultaneously treat multiple symptoms when used as directed in adults and children. A combination of Paracetamol, Levocetirizine and Phenylephrine is readily available and studied for the treatment of common cold and allergic rhinitis in adults.…”

Observational Study of a Multi-Active Ingredient Over-the-Counter Cold Remedy Following Active Pharmacist Recommendation

“…There is no cure for the common cold hence the treatment is focused largely on OTC medicines to reduce symptom severity to maintain patient performance and quality of life [8] [9]. As such, multi-symptom relief cold remedies containing several active ingredients can provide advantages to the care-giver and patient when used as directed [10].…”

Safety and Efficacy of a Combination of Paracetamol, Phenylephrine and Fexofenadine in Adult Patients of Common Cold and Allergic Rhinitis: Phase Iv Study

“…As per the DPHHS guidelines [2] , Cochrane review [1] , Eccles R [6] et al and Picon PD et al [7] combination of antihistamine, decongestant and analgesic provides benefits in adults for multi symptom relief in common cold and allergic rhinitis.…”